- Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-(2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models
[作者:PAYNE JOSEPH E; BONNEFOUS CELINE; SYMONS KENT T; NGUYEN PHAN M; SABLAD MARCIANO; ROZENKRANTS NATASHA; ZHANG YAN; WANG LI; YAZDANI NAHID; SHIAU ANDREW K; NOBLE STEWART A; RIX PETER; RAO TADIMETI S; HASSIG CHRISTIAN A; SMITH NICHOLAS D,期刊:Journal of Medicinal Chemistry, 页码:7739-7755 , 文章类型: Article,,卷期:2010年53-21]
- Three isoforms of nitric oxide synthase (NOS), dimeric enzymes that catalyze the formation of nitric oxide (NO) from arginine, have been identified. Inappropriate or excessive NO produced by iNOS and/or nNOS is associate...
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