- Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to Develop Extremely Potent Inhibitors.
[作者：Butini, Stefania;Campiani, Giuseppe;Borriello, Marianna;Gemma, Sandra;Panico, Alessandro;Persico, Marco;Catalanotti, Bruno;Ros, Sindu;Brindisi, Margherita;Agnusdei, Marianna;Fiorini, Isabella;Nacci, Vito;Novellino, Ettore;Belinskaya, Tatyana;Saxena, Ashim,期刊：Journal of Medicinal Chemistry, 页码：3154-3170 , 文章类型： 研究论文，,卷期：2008年51-11]
- Protein conformational fluctuations are crit. for biol. functions, although the relationship between protein motion and function has yet to be fully explored. By a thorough bioinformatics anal. of cholinesterases (ChEs)...
- Novel 3-Carboxamide-coumarins as Potent and Selective FXIIa Inhibitors.
[作者：Robert, Severine;Bertolla, Carine;Masereel, Bernard;Dogne, Jean-Michel;Pochet, Lionel;,期刊：Journal of Medicinal Chemistry, 页码：3077-3080 , 文章类型： 研究论文，,卷期：2008年51-11]
- Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of...
- Discovery of Novel Human Histamine H4 Receptor Ligands by Large-Scale Structure-Based Virtual Screening.
[作者：Kiss, Robert;Kiss, Bela;Konczol, Arpad;Szalai, Ferenc;Jelinek, Ivett;Laszlo, Valeria;Noszal, Bela;Falus, Andras;Keseru, Gyorgy M.;,期刊：Journal of Medicinal Chemistry, 页码：3145-3153 , 文章类型： 研究论文，,卷期：2008年51-11]
- A structure-based virtual screening (SBVS) was conducted on a ligand-supported homol. model of the human histamine H4 receptor (hH4R). More than 8.7 million 3D structures derived from different vendor databases were inv...
- Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit.
[作者：Hu, Essa;Tasker, Andrew;White, Ryan D.;Kunz, Roxanne K.;Human, Jason;Chen, Ning;Burli, Roland;Hungate, Randall;Novak, Perry;Itano, Andrea;Zhang, Xuxia;Yu, Violeta;Nguyen, Yen;Tudor, Yanyan;Plant, Matthew;Flynn, Shaun;Xu, Yang;Meagher, Kristin L.;Whittingt,期刊：Journal of Medicinal Chemistry, 页码：3065-3068 , 文章类型： 研究论文，,卷期：2008年51-11]
- diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and Src. In vivo efficacy of pyridone 16 (I)by d...
- Modulating the Therapeutic Activity of Nanoparticle Delivered Paclitaxel by Manipulating the Hydrophobicity of Prodrug Conjugates.
[作者：Ansell, Steven M.;Johnstone, Sharon A.;Tardi, Paul G.;Lo, Lily;Xie, Sherwin;Shu, Yu;Harasym, Troy O.;Harasym, Natashia L.;Williams, Laura;Bermudes, David;Liboiron, Barry D.;Saad, Walid;Prud'homme, Robert K.;Mayer, Lawrence D.;,期刊：Journal of Medicinal Chemistry, 页码：3288-3296 , 文章类型： 研究论文，,卷期：2008年51-11]
- A series of paclitaxel prodrugs designed for formulation in lipophilic nanoparticles are described. The hydrophobicity of paclitaxel was increased by conjugating a succession of increasingly hydrophobic lipid anchors to...
- Design and Synthesis of FAJANU: a de Novo C2 Symmetric Cyclopeptide Family.
[作者：Garcia-Martin, Fayna;Cruz, Luis J.;Rodriguez-Mias, Ricard A.;Giralt, Ernest;Albericio, Fernando;,期刊：Journal of Medicinal Chemistry, 页码：3194-3202 , 文章类型： 研究论文，,卷期：2008年51-11]
- A novel cyclic peptide has been designed from several potent marine cytotoxic peptides, including IB-01212, luzopeptin, triostin, and thiocoraline. The FAJANU scaffold maintains C2 symmetry, cyclic structure, and the co...
- Design, Synthesis, and Biological Evaluation of New-Generation Taxoids.
[作者：Ojima, Iwao;Chen, Jin;Sun, Liang;Borella, Christopher P.;Wang, Tao;Miller, Michael L.;Lin, Songnian;Geng, Xudong;Kuznetsova, Larisa;Qu, Chuanxing;Gallager, David;Zhao, Xianrui;Zanardi, Ilaria;Xia, Shujun;Horwitz, Susan B.;Mallen-St. Clair, Jon;Guerriero,,期刊：Journal of Medicinal Chemistry, 页码：3203-3221 , 文章类型： 研究论文，,卷期：2008年51-11]
- Novel second-generation taxoids with systematic modifications at the C2, C10, and C3'N positions were synthesized and their structure-activity relationships studied. A no. of these taxoids exhibited exceptionally high p...
- Tuning the DNA Conformational Perturbations Induced by Cytotoxic Platinum-Acridine Bisintercalators: Effect of Metal Cis/Trans Isomerism and DNA Threading Groups.
[作者：Choudhury, Jayati Roy;Guddneppanavar, Rajsekhar;Saluta, Gilda;Kucera, Gregory L.;Bierbach, Ulrich;,期刊：Journal of Medicinal Chemistry, 页码：3069-3072 , 文章类型： 研究论文，,卷期：2008年51-11]
- Four highly charged, water sol. platinum-acridine bisintercalating agents have been synthesized. Depending on the cis/trans isomerism of the metal and the nature of the acridine side chains, bisintercalation induces/sta...
- Activity-Based Probe for Specific Photoaffinity Labeling g-Aminobutyric Acid B (GABAB) Receptors on Living Cells: Design, Synthesis, and Biological Evaluation.
[作者：Li, Xin;Cao, Jian-Hua;Li, Ying;Rondard, Philippe;Zhang, Yang;Yi, Ping;Liu, Jian-Feng;Nan, Fa-Jun;,期刊：Journal of Medicinal Chemistry, 页码：3057-3060 , 文章类型： 研究论文，,卷期：2008年51-11]
- characterized, and applied to photoaffinity label the GABAB receptors transiently expressed in Chinese hamster ovary (CHO) cells. The probe exhibits specific binding activity at the ligand-binding pocket of GB1 subunits...
- Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability.
[作者：Charrier, Nicolas;Clarke, Brian;Cutler, Leanne;Demont, Emmanuel;Dingwall, Colin;Dunsdon, Rachel;East, Philip;Hawkins, Julie;Howes, Colin;Hussain, Ishrut;Jeffrey, Phil;Maile, Graham;Matico, Rosalie;Mosley, Julie;Naylor, Alan;O'Brien, Alistair;Redshaw, Sall,期刊：Journal of Medicinal Chemistry, 页码：3313-3317 , 文章类型： 研究论文，,卷期：2008年51-11]
- BACE-1 inhibition has the potential to provide a disease-modifying therapy for the treatment of Alzheimer's disease. Optimization of a first generation of BACE-1 inhibitors led to the discovery of novel hydroxyethylamin...
- Polyamine-Polycarboxylate Metal Complexes with Different Biological Effectiveness as Nitric Oxide Scavengers. Clues for Drug Design.
[作者：Bambagioni, Valentina;Bani, Daniele;Bencini, Andrea;Biver, Tarita;Cantore, Miriam;Chelli, Riccardo;Cinci, Lorenzo;Failli, Paola;Ghezzi, Lisa;Giorgi, Claudia;Nappini, Silvia;Secco, Fernando;Tine, Maria Rosaria;Valtancoli, Barbara;Venturini, Marcella;,期刊：Journal of Medicinal Chemistry, 页码：3250-3260 , 文章类型： 研究论文，,卷期：2008年51-11]
- The synthesis of the Fe(III), Co(II), Mn(II), and Ru(III) complexes with two polyamine-polycarboxylate ligands, N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid (H3L1) and ethylene bisglycol tetraacetic acid (H4L...
- Histone Deacetylase Inhibitors: From Bench to Clinic. [Erratum to document cited in CA148:393494].
[作者：Paris, Marielle;Porcelloni, Marina;Binaschi, Monica;Fattori, Daniela;,期刊：Journal of Medicinal Chemistry, 页码：3330-3330 , 文章类型： 综述，,卷期：2008年51-11]
- A review. On page 1506, in Figure 1, the structure given for compd. 1I (SB-939) is incorrect. The correct structure for this compd. has been reproduced.
- Interaction of Antagonists with Calmodulin: Insights from Molecular Dynamics Simulations.
[作者：Kovesi, Istvan;Menyhard, Dora K.;Laberge, Monique;Fidy, Judit;,期刊：Journal of Medicinal Chemistry, 页码：3081-3093 , 文章类型： 研究论文，,卷期：2008年51-11]
- The authors report results of 12 ns, all-atom mol. dynamics simulation (MDS) and Poisson-Boltzmann free energy calcns. (PBFE) on calmodulin (CaM) bound to two mols. of trifluoperazine (TFP) and of N-(3,3, diphenylpropyl)...
- Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.
[作者：La Motta, Concettina;Sartini, Stefania;Salerno, Silvia;Simorini, Francesca;Taliani, Sabrina;Marini, Anna Maria;Da Settimo, Federico;Marinelli, Luciana;Limongelli, Vittorio;Novellino, Ettore;,期刊：Journal of Medicinal Chemistry, 页码：3182-3193 , 文章类型： 研究论文，,卷期：2008年51-11]
- (Heterocyclic Compounds (More Than One Hetero Atom)) Section A no. of 1,2,4-oxadiazol-5-ylacetic acids and oxazol-4-ylacetic acids were synthesized and tested for their ability to inhibit aldose reductase (ALR2). Severa...
- Development of novel antiatherogenic biaryls: design, synthesis, and reactivity.
[作者：Delomenede, Melanie;Bedos-Belval, Florence;Duran, Hubert;Vindis, Cecile;Baltas, Michel;Negre-Salvayre, Anne;,期刊：Journal of Medicinal Chemistry, 页码：3171-3181 , 文章类型： 研究论文，,卷期：2008年51-11]
- On the basis of the 5,5'-bisvanillin scaffold, a series of compds. has been synthesized presenting sym. or dissym. frames on each phenolic moiety. These frames are a,b-unsatd. (fluoro)phosphonate and/or a,b-unsatd. hydr...
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