- Synthesis of Somatostatin Analogues Containing C-Terminal Adamantane and Their Antiproliferative Properties.
[作者:Miyazaki, Anna;Tsuda, Yuko;Fukushima, Shoji;Yokoi, Toshio;Vantus, Tibor;Bokonyi, Gyongyi;Szabo, Edit;Horvath, Aniko;Keri, Gyorgy;Okada, Yoshio;,期刊:Journal of Medicinal Chemistry, 页码:5121-5124 , 文章类型: 研究论文,,卷期:2008年51-16]
- On the basis of the structure of somatostatin analog TT-232, which exhibited a highly potent antitumor activity, the authors synthesized small linear peptide amides and evaluated their antitumor and apoptotic activity. ...
- Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxa mide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
[作者:Wyatt, Paul G.;Woodhead, Andrew J.;Berdini, Valerio;Boulstridge, John A.;Carr, Maria G.;Cross, David M.;Davis, Deborah J.;Devine, Lindsay A.;Early, Theresa R.;Feltell, Ruth E.;Lewis, E. Jonathan;McMenamin, Rachel L.;Navarro, Eva F.;O'Brien, Michael A.;O'R,期刊:Journal of Medicinal Chemistry, 页码:4986-4999 , 文章类型: 研究论文,,卷期:2008年51-16]
- The application of fragment-based screening techniques to cyclin dependent kinase 2 (CDK2) identified multiple (>30) efficient, synthetically tractable small mol. hits for further optimization. Structure-based design app...
- Novel Amidino-Substituted Thienyl- and Furylvinylbenzimidazole: Derivatives and Their Photochemical Conversion into Corresponding Diazacyclopenta[c]fluorenes. Synthesis, Interactions with DNA and RNA, and Antitumor Evaluation. 4.
[作者:Hranjec, Marijana;Piantanida, Ivo;Kralj, Marijeta;Suman, Lidija;Pavelic, Kresimir;Karminski-Zamola, Grace;,期刊:Journal of Medicinal Chemistry, 页码:4899-4910 , 文章类型: 研究论文,,卷期:2008年51-16]
- Synthesis of novel nonfused amidino-substituted thienyl- and furylvinylbenzimidazoles I (X = O, S; R1 = H, R2 = H, Me2CH, cyclohexyl, 4-morpholinyl; R1R2 = CH2CH2) and their photochem. cyclization into the corresponding ...
- Facile Radiosynthesis of Fluorine-18 Labeled b-Blockers. Synthesis, Radiolabeling, and ex Vivo Biodistribution of [18F]-(2S and 2R)-1-(1-Fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol.
[作者:Stephenson, Karin A.;Wilson, Alan A.;Meyer, Jeffrey H.;Houle, Sylvain;Vasdev, Neil;,期刊:Journal of Medicinal Chemistry, 页码:5093-5100 , 文章类型: 研究论文,,卷期:2008年51-16]
- An efficient and general method has been developed for fluorine-18 labeling of b-blockers that possess the propanolamine moiety. A new synthetically versatile intermediate, oxazolidinone I, was prepd. and can be conjuga...
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