An efficient approach has been described for the synthesis of 3,5-disubstituted isoxazoles from propargylic alcohols. The strategy involves a one-pot p-TSA-catalyzed N-propargylation of protected hydroxylamines followed ...
In our ongoing research program into the discovery of new anticancer drugs , we were interested in the preparation of naphthoquinone scaffolds bearing aminoalkyl side-chains. Following this aim, we revisited the KochiAnd...
The syntheses of the marine sponge-derived ?-amino carboxylic acid dysibetaine CPa and five analogs in their racemic forms were successfully performed by taking advantage of an electron-withdrawing N-(4-nitrophenyl) grou...
A new cycloisomerization strategy for the synthesis of coumarins and quinolinones is described. The addition of ethoxyacetylide to 2-hydroxyacetophenones directly resulted in 4-substituted coumarins by 6-endo-dig cyclois...
A series of rosamine fluorophores was obtained by reaction of the appropriate benzaldehyde and 3-(diethylamino)phenol followed by an oxidation step. Both conventional heating and microwave irradiation methods were utiliz...
Orchids of the genus Chiloglottis rely on sexual deception to attract a male thynnine wasp, whereupon a courtship routine results in the deposition and transfer of pollinia and subsequent pollination of the orchid. The c...
The reaction of new, chiral, proline-based naphthyl diynes with different nitriles through a key [2+2+2] cycloaddition reaction step catalyzed by CoIolefin complexes under thermal and photochemical conditions gave diaste...
The catalytic asymmetric FriedelCrafts alkylation of N-methylindoles with nitroalkenes catalyzed by bifunctional abietic-acid-derived thiourea-ZnII complexes was investigated. Various types of the nitroalkylated indoles ...
Arynes are regarded as potential and versatile intermediates in organic synthesis. These highly-reactive, strained and kinetically unstable species have numerous applications in synthetic chemistry. In this article, a hi...
The synthesis of a model 1-O-(?-aminoacyl)-IP2 derivative, lauryl 4,5-bisphosphate 31, was realized following a versatile and high-yielding scheme. The flexible synthetic strategy used for this purpose allows the prepara...