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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共400948条记录   Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines [作者：PEDEBOSCQ STEPHANE; GRAVIER DENIS; CASADEBAIG FRANCOISE; HOU GENEVIEVE; GISSOT ARNAUD; REY CHRISTOPHE; ICHAS FRANCOIS; DE GIORGI FRANCESCA; LARTIGUE LYDIA; POMETAN JEANPAUL,期刊：Bioorganic & Medicinal Chemistry, 页码：6724-6731 , 文章类型： Article，,卷期：2012年20-22] Monoclonal antibodies (MoAb) and tyrosine kinase inhibitors (TKI) targeting the EGFR (Epidermal Growth Factor Receptor) pathways are currently used in colorectal cancer treatment. Despite the improvement of median overal... Coordination of iron ions in the form of histidinyl dinitrosyl complexes does not prevent their genotoxicity [作者：LEWANDOWSKA HANNA; STEPKOWSKI TOMASZ M; SADLO JAROSLAW; WOJCIUK GRZEGORZ P; WOJCIUK KAROLINA E; RODGER ALISON; KRUSZEWSKI MARCIN,期刊：Bioorganic & Medicinal Chemistry, 页码：6732-6738 , 文章类型： Article，,卷期：2012年20-22] Formation of dinitrosyl iron complexes (DNICs) was observed in a wide spectrum of pathophysiological conditions associated with overproduction of NO. To gain insight into the possible genotoxic effects of DNIC, we examin... Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, A beta aggregation, and beta-secretase [作者：PENG DAYONG; SUN QI; ZHU XIAOLEI; LIN HONGYAN; CHEN QIONG; YU NINGXI; YANG WENCHAO; YANG GUANGFU,期刊：Bioorganic & Medicinal Chemistry, 页码：6739-6750 , 文章类型： Article，,卷期：2012年20-22] Alzheimer's disease (AD) is a multifactorial syndrome with several target proteins contributing to its etiology. In this study, we conducted a structure-based design and successfully produced a series of new multi-site A... Asymmetric Hydrogenation of a,ss-Unsaturated Carboxylic Esters with Chiral Iridium N,P Ligand Complexes [作者：WOODMANSEE DAVID H; MUELLER MARCANDRE; TROENDLIN LARS; HOERMANN ESTHER; PFALTZ ANDREAS,期刊：Chemistry-A European Journal, 页码：13780-13786 , 文章类型： Article，,卷期：2012年18-43] Enantioselective conjugate reduction of a wide range of alpha,beta-unsaturated carboxylic esters was achieved using chiral Ir N,P complexes as hydrogenation catalysts. Depending on the substitution pattern of the substra... Supramolecular Assembly of Diplatinum Species through Weak PtII center dot center dot center dot PtII Intermolecular Interactions: A Combined Experimental and Computational Study [作者：PEREZ PAZ ALEJANDRO; ESPINOSA LEAL LEONARDO A; AZANI MOHAMMADREZA; GUIJARRO ALEJANDRO; SANZ MIGUEL PABLO J; GIVAJA GONZALO; CASTILLO OSCAR; MASBALLESTE RUBEN; ZAMORA FELIX; RUBIO ANGEL,期刊：Chemistry-A European Journal, 页码：13787-13799 , 文章类型： Article，,卷期：2012年18-43] The present study elucidates the factors that govern the spontaneous self-assembly of a family of dimetal [Pt2L4] (L=dithiocarboxylato ligand) complexes. Experimental data show that variables such as temperature, concent... Graphene Nanosheets as a Platform for the 2D Ordering of Metal Oxide Nanoparticles: Mesoporous 2D Aggregate of Anatase TiO2 Nanoparticles with Improved Electrode Performance [作者：LEE JANG MEE; KIM IN YOUNG; HAN SONG YI; KIM TAE WOO; HWANG SEONGJU,期刊：Chemistry-A European Journal, 页码：13800-13809 , 文章类型： Article，,卷期：2012年18-43] Graphene nanosheets are successfully applied as an effective platform for the 2D ordering of metal oxide nanoparticles. Mesoporous 2D aggregates of anatase TiO2 nanoparticles are synthesized by the heat treatment of the ... Preparation of Stable Low-Oxidation-State Group 14 Element Amidohydrides and Hydride-Mediated Ring-Expansion Chemistry of N-Heterocyclic Carbenes [作者：ALRAFIA S M IBRAHIM; MCDONALD ROBERT; FERGUSON MICHAEL J; RIVARD ERIC,期刊：Chemistry-A European Journal, 页码：13810-13820 , 文章类型： Review，,卷期：2012年18-43] Various low oxidation state (+2) group 14 element amidohydride adducts, IPr center dot EH(BH3)NHDipp (E=Si or Ge; IPr=[(HCNDipp)2C:], Dipp=2,6-iPr2C6H3), were synthesized. Thermolysis of the reported adducts was investig... Sterically Hindered o-Quinone Annulated with Dithiete: A Molecule Comprising Diolate and Dithiolate Coordination Sites [作者：CHERKASOV VLADIMIR K; ABAKUMOV GLEB A; FUKIN GEORGY K; KLEMENTYEVA SVETLANA V; KUROPATOV VIACHESLAV A,期刊：Chemistry-A European Journal, 页码：13821-13827 , 文章类型： Article，,卷期：2012年18-43] A new stable sterically hindered o-quinone annelated with a 1,2-dithiete ring was prepared by using mild conditions. The skeleton of the compound comprises diolate and dithiolate functions that have the potential to bind... Mechanism of the Pd-catalyzed Decarboxylative Allylation of alpha-Imino Esters: Decarboxylation via Free Carboxylate Ion [作者：LI ZHE; JIANG YUANYE; YEAGLEY ANDREW A; BOUR JAMES P; LIU LEI; CHRUMA JASON J; FU YAO,期刊：Chemistry-A European Journal, 页码：14527-14538 , 文章类型： Review，,卷期：2012年18-45] The Pd-catalyzed decarboxylative allylation of a-(diphenylmethylene)imino esters (1) or allyl diphenylglycinate imines (2) is an efficient method to construct new C(sp3)?C(sp3) bonds. The detailed mechanism of this react... Assignment of Relative Configuration of Desoxypropionates by H-1 NMR Spectroscopy: Method Development, Proof of Principle by Asymmetric Total Synthesis of Xylarinic Acid A and Applications (vol 18, pg 7071, 2012) [作者：SCHMIDT Y; LEHR K; COLAS L; BREIT B,期刊：Chemistry-A European Journal, 页码：CP43-CP43 , 文章类型： Correction，,卷期：2012年18-45] Structural design principles for self-assembled coordination polygons and polyhedra [作者：YOUNG NEIL J; HAY BENJAMIN P,期刊：Chemical Communications, 页码：1354-1379 , 文章类型： Article，,卷期：2013年49-14] Strategies for the design of ligands that combine with metal ions to form high-symmetry coordination assemblies are reviewed. Evaluation of crystal structure evidence reveals that prior design approaches, based on the co... DNA mediated immobilisation of electrocatalytic platinum nanoparticles in gold nanocavity arrays [作者：MALLON COLM T; SPAIN ELAINE; KEYES TIA E; FORSTER ROBERT J,期刊：Chemical Communications, 页码：1380-1382 , 文章类型： Article，,卷期：2013年49-14] Platinum nanoparticles, functionalised regioselectively with probe strand DNA, have been immobilised within the interior of gold nanocavity arrays via DNA hybridisation. The immobilised nanoparticles are highly electroca... A microfluidic origami electrochemiluminescence aptamer-device based on a porous Au-paper electrode and a phenyleneethynylene derivative [作者：YAN JIXIAN; YAN MEI; GE LEI; YU JINGHUA; GE SHENGUANG; HUANG JIADONG,期刊：Chemical Communications, 页码：1383-1385 , 文章类型： Article，,卷期：2013年49-14] A simple, low-cost, and sensitive 3D microfluidic origami electrochemiluminescence aptamer-device was developed based on a novel gold nanoparticle modified porous paper working electrode for point-of-care diagnosis. [F-18]Fluorination of an arylboronic ester using [F-18]selectfluor bis(triflate): application to 6-[F-18]fluoro-L-DOPA [作者：STENHAGEN IDA S R; KIRJAVAINEN ANNA K; FORSBACK SARITA J; JORGENSEN CHARLOTTE G; ROBINS EDWARD G; LUTHRA SAJINDER K; SOLIN OLOF; GOUVERNEUR VERONIQUE,期刊：Chemical Communications, 页码：1386-1388 , 文章类型： Article，,卷期：2013年49-14] The Ag-mediated electrophilic [F-18]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [F-18]selectfluor bis(triflate) in acetone. The process gave 6-[F-18]-fluoro-L-DOPA with a ... A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation [作者：ZHANG QINGZHI; KULCZYNSKA AGNIESZKA; WEBB DAVID J; MEGSON IAN L; BOTTING NIGEL P,期刊：Chemical Communications, 页码：1389-1391 , 文章类型： Article，,卷期：2013年49-14] This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for... Sugar complexation to silicone boronic acids [作者：BROOK MICHAEL A; DODGE LAURA; CHEN YANG; GONZAGA FERDINAND; AMARNE HAZEM,期刊：Chemical Communications, 页码：1392-1394 , 文章类型： Article，,卷期：2013年49-14] A new class of surface-active compounds based on the combination of silicones and boronic acids is described. The properties of the compounds can be tuned by manipulation of both the hydrophobic (silicone size and 3D str...