- Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis
[作者:Nishikimi, A; Fukuhara, H; Su, WJ; Hongu, T; Takasuga, S; Mihara, H; Cao, QH; Sanematsu, F; Kanai, M; Hasegawa, H; Tanaka, Y; Shibasaki, M; Kanaho, Y; Sasaki, T; Frohman, MA; Fukui, Y,期刊:Science, 页码:384-387 , 文章类型: Article,,卷期:2009年324-5925]
- During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac activation is primarily ...
- Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
[作者:Nejentsev, S; Walker, N; Riches, D; Egholm, M; Todd, JA,期刊:Science, 页码:387-389 , 文章类型: Article,,卷期:2009年324-5925]
- Genome-wide association studies (GWASs) are regularly used to map genomic regions contributing to common human diseases, but they often do not identify the precise causative genes and sequence variants. To identify causa...
- Geometric frustration in buckled colloidal monolayers
[作者:Han, Yilong; Shokef, Yair; Alsayed, Ahmed M.; Yunker, Peter; Lubensky, Tom C.; Yodh, Arjun G.,期刊:NATURE, 页码:898-903 , 文章类型: 研究论文,,卷期:2008年456-7224]
- Geometric frustration arises when lattice structure prevents simultaneous minimization of local interaction energies. It leads to highly degenerate ground states and, subsequently, to complex phases of matter, such as wa...
- Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation
[作者:Kang, Rujun; Wan, Junmei; Arstikaitis, Pamela; Takahashi, Hideto; Huang, Kun; Bailey, Aaron O.; Thompson, James X.; Roth, Amy F.; Drisdel, Renaldo C.; Mastro, Ryan; Green, William N.; Yates, John R., III; Davis, Nicholas G.; El-Husseini, Alaa,期刊:NATURE, 页码:904-909 , 文章类型: 研究论文,,卷期:2008年456-7224]
- Palmitoylation regulates diverse aspects of neuronal protein trafficking and function. Here a global characterization of rat neural palmitoyl- proteomes identifies most of the known neural palmitoyl proteins - 68 in tota...
- Acylated Iridoids with Cytotoxicity from Valeriana jatamansi
[作者:Lin, S; Shen, YH; Li, HL; Yang, XW; Chen, T; Lu, LH; Huang, ZS; Liu, RH; Xu, XK; Zhang, WD; Wang, H,期刊:Journal of natural products, 页码:650-655 , 文章类型: Article,,卷期:2009年72-4]
- Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these ...
- Antioxidant Hydroquinones Substituted by beta-1,6-Linked Oligosaccharides in Wheat Germ
[作者:Zhokhov, SS; Jastrebova, JA; Kenne, L; Broberg, A,期刊:Journal of natural products, 页码:656-661 , 文章类型: Article,,卷期:2009年72-4]
- Seven new compounds that demonstrate antioxidant properties, 4-hydroxy-3-methoxyphenyl beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranoside (1), 4-hydroxyphenyl beta-D-glucopyranosyl-(1 ->...
- Chromones from the Endophytic Fungus Pestalotiopsis sp Isolated from the Chinese Mangrove Plant Rhizophora mucronata
[作者:Xu, J; Kjer, J; Sendker, J; Wray, V; Guan, HS; Edrada, R; Lin, WH; Wu, J; Proksch, P,期刊:Journal of natural products, 页码:662-665 , 文章类型: Article,,卷期:2009年72-4]
- Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pesta...
- Spliceosomal cleavage generates the 3 ' end of telomerase RNA
[作者:Box, Jessica A.; Bunch, Jeremy T.; Tang, Wen; Baumann, Peter,期刊:NATURE, 页码:910-U71 , 文章类型: 研究论文,,卷期:2008年456-7224]
- Telomeres cap the ends of chromosomes and provide a means to complete replication. The DNA portion of telomeres is synthesized by the enzyme telomerase using part of an RNA subunit as a template for reverse transcription...
- Antigenic variation in Giardia lamblia is regulated by RNA interference
[作者:Prucca, Cesar G.; Slavin, Ileana; Quiroga, Rodrigo; Elias, Eliana V.; Rivero, Fernando D.; Saura, Alicia; Carranza, Pedro G.; Lujan, Hugo D.,期刊:NATURE, 页码:750-754 , 文章类型: 研究论文,,卷期:2008年456-7223]
- Giardia lamblia ( also called Giardia intestinalis) is one of the most common intestinal parasites of humans. To evade the host's immune response, Giardia undergoes antigenic variation - a process that allows the parasit...
- Cottoquinazoline A and Cotteslosins A and B, Metabolites from an Australian Marine-Derived Strain of Aspergillus versicolor
[作者:Fremlin, LJ; Piggott, AM; Lacey, E; Capon, RJ,期刊:Journal of natural products, 页码:666-670 , 文章类型: Article,,卷期:2009年72-4]
- An Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) yielded the known fungal metabolites sterigmatocystin, violaccol I, violaceol II, diorcinol, (-)-cyclopenol, and viridicatol, along with a new al...
- Dihydrostilbene Derivatives from the Mongolian Medicinal Plant Scorzonera radiata
[作者:Wang, Y; Edrada-Ebel, R; Tsevegsuren, N; Sendker, J; Braun, M; Wray, V; Lin, WH; Proksch, P,期刊:Journal of natural products, 页码:671-675 , 文章类型: Article,,卷期:2009年72-4]
- Chromatographic separation of a crude extract obtained from aerial parts of the Mongolian medicinal plant Scorzonera radiata yielded five new dihydrostilbenes, scorzodihydrostilbenes A-E (1-5). The structures were unambi...
- Schisanwilsonenes A-C, Anti-HBV Carotane Sesquiterpenoids from the Fruits of Schisandra wilsoniana
[作者:Ma, WH; Huang, H; Zhou, P; Chen, DF,期刊:Journal of natural products, 页码:676-678 , 文章类型: Article,,卷期:2009年72-4]
- Three carotane-type sesquiterpenoids, schisanwilsonenes A (1), B (2), and C (3), were isolated from the fruits of Schisandra wilsoniana. Their structures and relative configurations were elucidated on the basis of spectr...
- Semisynthesis and Biological Activity of Stemofoline Alkaloids
[作者:Baird, MC; Pyne, SG; Ung, AT; Lie, W; Sastraruji, T; Jatisatienr, A; Jatisatienr, C; Dheeranupattana, S; Lowlam, J; Boonchalermkit, S,期刊:Journal of natural products, 页码:679-684 , 文章类型: Article,,卷期:2009年72-4]
- The semisynthesis of the Stemona alkaloids (3'R)-stemofolenol (1). (3'S)-stemofolenol (2), methylstemofoline (3), and (3'S)-hydroxystemofoline (5) and the unnatural analogues (11E)-methylstemofoline (15) and 3'R-hydroxys...
- Negative feedback that improves information transmission in yeast signalling
[作者:Yu, Richard C.; Pesce, C. Gustavo; Colman-Lerner, Alejandro; Lok, Larry; Pincus, David; Serra, Eduard; Holl, Mark; Benjamin, Kirsten; Gordon, Andrew; Brent, Roger,期刊:NATURE, 页码:755-761 , 文章类型: 研究论文,,卷期:2008年456-7223]
- Haploid Saccharomyces cerevisiae yeast cells use a prototypic cell signalling system to transmit information about the extracellular concentration of mating pheromone secreted by potential mating partners. The ability of...
- Terpenoids from Toona ciliata
[作者:Chen, HD; Yang, SP; Wu, Y; Dong, L; Yue, JM,期刊:Journal of natural products, 页码:685-689 , 文章类型: Article,,卷期:2009年72-4]
- Three new norlimonoids (1-3), two new tirucallane-type triterpenoids (4 and 5), and a new pimaradiene-type diterpenoid (6), along with two known limonoids and eight known tirucallane-type triterpenoids, were isolated fro...
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