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Acylated Iridoids with Cytotoxicity from Valeriana jatamansi

  作者 Lin, S; Shen, YH; Li, HL; Yang, XW; Chen, T; Lu, LH; Huang, ZS; Liu, RH; Xu, XK; Zhang, WD; Wang, H  
  选自 期刊  Journal of natural products;  卷期  2009年72-4;  页码  650-655  
  关联知识点  
 

[摘要]Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.

 
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