- Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties.
[作者:Simoni, Daniele;Rondanin, Riccardo;Baruchello, Riccardo;Rizzi, Michele;Grisolia, Giuseppina;Eleopra, Marco;Grimaudo, Stefania;Di Cristina, Antonietta;Pipitone, Maria Rosaria;Bongiorno, Maria Rita;Arico, Mario;Invidiata, Francesco Paolo;Tolomeo, Manlio;,期刊:Journal of Medicinal Chemistry, 页码:4796-4803 , 文章类型: 研究论文,,卷期:2008年51-15]
- A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivs., maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compds. with growth supporting and antiapoptotic properties. Un...
- Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]- 2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor.
[作者:Harris, Philip A.;Boloor, Amogh;Cheung, Mui;Kumar, Rakesh;Crosby, Renae M.;Davis-Ward, Ronda G.;Epperly, Andrea H.;Hinkle, Kevin W.;Hunter, Robert N., III;Johnson, Jennifer H.;Knick, Victoria B.;Laudeman, Christopher P.;Luttrell, Deirdre K.;Mook, Robert A,期刊:Journal of Medicinal Chemistry, 页码:4632-4640 , 文章类型: 研究论文,,卷期:2008年51-15]
- Inhibition of the vascular endothelial growth factor (VEGF) signaling pathway has emerged as one of the most promising new approaches for cancer therapy. We describe herein the key steps starting from an initial screeni...
- Structure-Based Development of Novel Adenylyl Cyclase Inhibitors.
[作者:Schlicker, Christine;Rauch, Annika;Hess, Ken C.;Kachholz, Barbara;Levin, Lonny R.;Buck, Jochen;Steegborn, Clemens;,期刊:Journal of Medicinal Chemistry, 页码:4456-4464 , 文章类型: 研究论文,,卷期:2008年51-15]
- In mammals, the second messenger cAMP is synthesized by a family of transmembrane isoforms (tmACs) and one known cytoplasmic enzyme, "sol." adenylyl cyclase (sAC). Understanding the individual contributions of these fam...
- High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogs.
[作者:Charoenchai, Laksana;Wang, Hongyan;Wang, Jia Bei;Aldrich, Jane V.;,期刊:Journal of Medicinal Chemistry, 页码:4385-4387 , 文章类型: 研究论文,,卷期:2008年51-15]
- A series of cyclic analogs with a lactam linkage were prepd. by solid phase peptide synthesis to explore possible biol. active conformation(s) of nociceptin/orphanin FQ (N/OFQ). cyclo[D-Asp7,Lys10]- and cyclo[Asp6,Lys10]...
- Selective Nucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2) Inhibitors: Nucleotide Mimetics Derived from Uridine-5'-carboxamide.
[作者:Brunschweiger, Andreas;Iqbal, Jamshed;Umbach, Frank;Scheiff, Anja B.;Munkonda, Mercedes N.;Sevigny, Jean;Knowles, Aileen F.;Muller, Christa E.;,期刊:Journal of Medicinal Chemistry, 页码:4518-4528 , 文章类型: 研究论文,,卷期:2008年51-15]
- Ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases, subtypes 1, 2, 3, 8 of NTPDases) dephosphorylate nucleoside tri- and diphosphates to the corresponding di- and monophosphates. The adenine and uracil nucleot...
- Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: A new entry based on nucleophilic substitution of the 4'-acetoxy group.
[作者:[Erratum to document cited in CA148:427120]. Haraguchi, Kazuhiro;Shimada, Hisashi;Tanaka, Hiromichi;Hamasaki, Takayuki;Baba, Masanori;Gullen, Elizabeth A.;Dutschman, Ginger E.;Cheng, Yung-Chi;,期刊:Journal of Medicinal Chemistry, 页码:4850-4850 , 文章类型: 研究论文,,卷期:2008年51-15]
- of Health (Grant A138204 to Y.-C.C.)" is missing. The complete Acknowledgement is given.
- Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
[作者:Cinelli, Maris A.;Morrell, Andrew;Dexheimer, Thomas S.;Scher, Evan S.;Pommier, Yves;Cushman, Mark;,期刊:Journal of Medicinal Chemistry, 页码:4609-4619 , 文章类型: 研究论文,,卷期:2008年51-15]
- inhibitors is effectively a "composite" of the natural products camptothecin and luotonin A and the synthetic indenoisoquinolines. The aromathecins have aroused considerable interest following the isolation and total syn...
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