个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共42条记录   Chitosan Derivatives as Novel Potential Heparin Reversal Agents [作者：KAMINSKI KAMIL; SZCZUBIALKA KRZYSZTOF; ZAZAKOWNY KAROLINA; LACH RADOSLAW; NOWAKOWSKA MARIA,期刊：Journal of Medicinal Chemistry, 页码：4141-4147 , 文章类型： Article，,卷期：2010年53-10] In emergency cases anticoagulant action of heparin needs to be stopped instantaneously, which is usually achieved by intravenous administration of protamine sulfate (PS). However, PS shows many adverse effects. The objec... Structure-Activity Relationships of 6-Methyl-benzo[b]thiophene-2-carboxylic Acid (1-{(S)-1-Benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl}cyclopentyl)amide, Potent Antagonist of the Neurokinin-2 Receptor [作者：FATTORI DANIELA; PORCELLONI MARINA; DANDREA PIERO; CATALIOTO ROSEMARIE; ETTORRE ALESSANDRO; GIULIANI SANDRO; MARASTONI ELENA; MAURO SANDRO; MEINI STEFANIA; ROSSI CRISTINA; ALTAMURA MARIA; MAGGI CARLO A,期刊：Journal of Medicinal Chemistry, 页码：4148-4165 , 文章类型： Article，,卷期：2010年53-10] As part of a project aimed at the identification of a series of small, orally available antagonists for the hNK(2) receptor, starting from one of our capped dipeptide libraries, we succeeded in the chemical optimization ... BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins [作者：WEI JUN; STEBBINS JOHN L; KITADA SHINICHI; DASH RUPESH; PLACZEK WILLIAM; REGA MICHELE F; WU BAINAN; CELLITTI JASON; ZHAI DAYONG; YANG LI; DAHL RUSSELL; FISHER PAUL B; REED JOHN C; PELLECCHIA MAURIZIO,期刊：Journal of Medicinal Chemistry, 页码：4166-4176 , 文章类型： Article，,卷期：2010年53-10] In our continued attempts to identify novel and effective pan-Bcl-2 antagonists, we have recently reported a series of compound 2 (Apogossypol) derivatives, resulting in the chiral compound 4 (8r). We report here the syn... Syntheses and Evaluation of Anticonvulsant Profile and Teratogenicity of Novel Amide Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide [作者：HEN NAAMA; BIALER MEIR; WLODARCZYK BOGDAN; FINNELL RICHARD H; YAGEN BORIS,期刊：Journal of Medicinal Chemistry, 页码：4177-4186 , 文章类型： Article，,卷期：2010年53-10] Despite the availability of 14 new antiepileptic drugs (AEDs), about 30% of epileptic patients are not seizure-free. Consequently there is substantial need to develop new effective AEDs. A novel class of aromatic amides ... Almiramides A-C: Discovery and Development of a New Class of Leishmaniasis Lead Compounds [作者：SANCHEZ LAURA M; LOPEZ DIOXELIS; VESELY BRIAN A; DELLA TOGNA GINA; GERWICK WILLIAM H; KYLE DENNIS E; LININGTON ROGER G,期刊：Journal of Medicinal Chemistry, 页码：4187-4197 , 文章类型： Article，,卷期：2010年53-10] Leishmaniasis is a debilitating disease caused by protozoan parasites of the genus Leishmania, which affects an estimated 12 million people worldwide. The discovery of new lead compounds for leishmaniasis is therefore a ... 2-Imino-thiazolidin-4-one Derivatives as Potent, Orally Active S1P(1) Receptor Agonists [作者：BOLLI MARTIN H; ABELE STEFAN; BINKERT CHRISTOPH; BRAVO ROBERTO; BUCHMANN STEPHAN; BUR DANIEL; GATFIELD JOHN; HESS PATRICK; KOHL CHRISTOPHER; MANGOLD CELINE; MATHYS BORIS; MENYHART KATALIN; MUELLER CLAUS; NAYLER OLIVER; SCHERZ MICHAEL; SCHMIDT GUNTHER; SIPPEL VIRGINIE; STEINER BEAT; STRASSER DANIEL; TREIBER ALEXANDER; WELLER THOMAS,期刊：Journal of Medicinal Chemistry, 页码：4198-4211 , 文章类型： Article，,卷期：2010年53-10] Sphingosine-l-phosphate (S1P) is a widespread lysophospholipid which displays a wealth of biological effects. Extracellular S1P conveys its activity through five specific G-protein coupled receptors numbered S1P(1) throu... Conformationally Constrained kappa Receptor Agonists: Stereoselective Synthesis and Pharmacological Evaluation of 6,8-Diazabicyclo[3.2.2]nonane Derivatives [作者：GEIGER CHRISTIAN; ZELENKA CHRISTEL; LEHMKUHL KIRSTIN; SCHEPMANN DIRK; ENGLBERGER WERNER; WUENSCH BERNHARD,期刊：Journal of Medicinal Chemistry, 页码：4212-4222 , 文章类型： Article，,卷期：2010年53-10] Three sets of stereoisomeric bicyclic kappa agonists with defined orientation of the pharmacophoric elements pyrrolidine and dichlorophenylacetamide were stereoselectively prepared and pharmacologically evaluated. Stereo... Structure-Activity Relationship of an Ozonide Carboxylic Acid (OZ78) against Fasciola hepatica [作者：ZHAO QINGJIE; VARGAS MIREILLE; DONG YUXIANG; ZHOU LIN; WANG XIAOFANG; SRIRAGHAVAN KAMARAJ; KEISER JENNIFER; VENNERSTROM JONATHAN L,期刊：Journal of Medicinal Chemistry, 页码：4223-4233 , 文章类型： Article，,卷期：2010年53-10] In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of our search for a trematocidal synthetic peroxide drug development candidate. We found that relatively small structural changes t... Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents [作者：GUPTA DEEPAK; YEDIDI RAVIKIRAN S; VARGHESE SHEEBA; KOVARI LADISLAU C; WOSTER PATRICK M,期刊：Journal of Medicinal Chemistry, 页码：4234-4247 , 文章类型： Article，,卷期：2010年53-10] Four aspartyl proteases known as plasmepsins are involved in the degradation of hemoglobin by Plasmodium falciparum, which causes a large percentage of malaria deaths. The enzyme plasmepsin II (Plm II) is the most extens... Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues [作者：ROMAGNOLI ROMEO; BARALDI PIER GIOVANNI; CRUZLOPEZ OLGA; CARA CARLOTA LOPEZ; CARRION MARIA DORA; BRANCALE ANDREA; HAMEL ERNEST; CHEN LONGCHUAN; BORTOLOZZI ROBERTA; BASSO GIUSEPPE; VIOLA GIAMPIETRO,期刊：Journal of Medicinal Chemistry, 页码：4248-4258 , 文章类型： Article，,卷期：2010年53-10] A series of 1-aryl-5-(3',4',5'-trimethoxyphenyl) derivatives and their related 1-(3',4',5'-trimethoxyphenyl)5-aryl-1,2,4-triazoles, designed as cis-restricted combretastatin analogues, were synthesized and evaluated for ...