- Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase
[作者:ARIPIRALA SRINIVAS; SZAJNMAN SERGIO H; JAKONCIC JEAN; RODRIGUEZ JUAN B; DOCAMPO ROBERTO; GABELLI SANDRA B; MARIO AMZEL L,期刊:Journal of Medicinal Chemistry, 页码:6445-6454 , 文章类型: Article,,卷期:2012年55-14]
- Linear 2-alkylaminoethyl-1,1-bisphosphonates are effective agents against proliferation of Trypanosoma cruzi, the etiologic agent of American trypanosomiasis (Chagas disease), exhibiting IC50 values in the nanomolar rang...
- 7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists
[作者:BARALDI PIER GIOVANNI; SAPONARO GIULIA; MOORMAN ALLAN R; ROMAGNOLI ROMEO; PRETI DELIA; BARALDI STEFANIA; RUGGIERO EMANUELA; VARANI KATIA; TARGA MARTINA; VINCENZI FABRIZIO; BOREA PIER ANDREA; TABRIZI MOJGAN AGHAZADEH,期刊:Journal of Medicinal Chemistry, 页码:6608-6623 , 文章类型: Article,,卷期:2012年55-14]
- Cannabinoid receptor agonists have gained attention as potential therapeutic targets of inflammatory and neuropathic pain. Here, we report the identification and optimization of a series of 7-oxo-[1,4]oxazino[2,3,4-ij]qu...
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