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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases [作者：HOCKOVA DANA; KEOUGH DIANNE T; JANEBA ZLATKO; WANG TZUHSUAN; DE JERSEY JOHN; GUDDAT LUKE W,期刊：Journal of Medicinal Chemistry, 页码：6209-6223 , 文章类型： Article，,卷期：2012年55-13] Hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)PRT) is crucial for the survival of malarial parasites Plasmodium falciparum (Pf) and Plasmodium vivax (Pv). Acyclic nucleoside phosphonates (ANPs) are inhi... A New Class of Highly Potent and Selective Endomorphin-1 Analogues Containing alpha-Methylene-beta-aminopropanoic Acids (Map) [作者：WANG YUAN; XING YANHONG; LIU XIN; JI HONG; KAI MING; CHEN ZONGYAO; YU JING; ZHAO DEPENG; REN HUI; WANG RUI,期刊：Journal of Medicinal Chemistry, 页码：6224-6236 , 文章类型： Article，,卷期：2012年55-13] A new class of endomorphin-1 (EM-1) analogues were synthesized by introduction of novel unnatural alpha-methylene-beta-amino acids (Map) at position 3 or/and position 4. Their binding and functional activity, metabolic s... An Ultrahigh Affinity D-Peptide Antagonist Of MDM2 [作者：ZHAN CHANGYOU; ZHAO LE; WEI XIAOLI; WU XUEJI; CHEN XISHAN; YUAN WEIRONG; LU WEIYUE; PAZGIER MARZENA; LU WUYUAN,期刊：Journal of Medicinal Chemistry, 页码：6237-6241 , 文章类型： Article，,卷期：2012年55-13] The oncoprotein MDM2 negatively regulates the activity and stability of the p53 tumor suppressor and is an important molecular target for anticancer therapy. Aided by mirror image phage display and native chemical ligati...