- Imidazoquines as Antimalarial and Antipneumocystis Agents
[作者:VALE NUNO; PRUDENCIO MIGUEL; MARQUES CATARINA A; COLLINS MARGARET S; GUT JIRI; NOGUEIRA FATIMA; MATOS JOANA; ROSENTHAL PHILIP J; CUSHION MELANIE T; DO ROSARIO VIRGILIO E; MOTA MARIA M; MOREIRA RUI; GOMES PAULA,期刊:Journal of Medicinal Chemistry, 页码:7800-7807 , 文章类型: Article,,卷期:2009年52-23]
- Peptidomimetic imidazolidin-4-one derivatives of primaquine (imidazoquines) recently displayed in vitro activity against blood schizonts of a chloroquine-resistant strain of Plasmodium falciparum. Preliminary studies wit...
- Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N '-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor
[作者:CHAO QI; SPRANKLE KELLY G; GROTZFELD ROBERT M; LAI ANDILIY G; CARTER TODD A; VELASCO ANNE MARIE; GUNAWARDANE RUWANTHI N; CRAMER MERRYL D; GARDNER MICHAEL F; JAMES JOYCE; ZARRINKAR PATRICK P; PATEL HITESH K; BHAGWAT SHRIPAD S,期刊:Journal of Medicinal Chemistry, 页码:7808-7816 , 文章类型: Article,,卷期:2009年52-23]
- Treatment of AM L patients with small molecule inhibitors of FLT3 kinase has been explored as a viable therapy. However, these agents arc found to be less than optimal for the treatment of AM L because of lack of suffici...
- Exploring the Importance of Piperazine N-Atoms for sigma(2) Receptor Affinity and Activity in a Series of Analogs of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)
[作者:BERARDI FRANCESCO; ABATE CARMEN; FERORELLI SAVINA; URICCHIO VINCENZO; COLABUFO NICOLA A; NISO MAURO; PERRONE ROBERTO,期刊:Journal of Medicinal Chemistry, 页码:7817-7828 , 文章类型: Article,,卷期:2009年52-23]
- sigma(2)-Agonist 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]p iperazine (7, PB 28), which proved to revert doxorubicin resistance in breast cancer cells, was taken as a template to prepare new ...
- Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development
[作者:WITTMAN MARK D; CARBONI JOAN M; YANG ZHENG; LEE FRANCIS Y; ANTMAN MELISSA; ATTAR RICARDO; BALIMANE PRAVEEN; CHANG CHIEHYING; CHEN CLIFF; DISCENZA LORELL; FRENNESSON DAVID; GOTTARDIS MARCO M; GREER ANN; HURLBURT WARREN; JOHNSON WALTER; LANGLEY DAVID R; LI AIXIN; LI JIANQING; LIU PEIYING; MASTALERZ HAROLD; MATHUR ARVIND; MENARD KRISTA; PATEL KARISHMA; SACK JOHN; SANG XIAOPENG; SAULNIER MARK; SMITH DANIEL; STEFANSKI KEVIN; TRAINOR GEORGE; VELAPARTHI UPENDER; ZHANG GUIFEN; ZIMMERMANN KURT; VYAS DOLATRAI M,期刊:Journal of Medicinal Chemistry, 页码:7360-7363 , 文章类型: Article,,卷期:2009年52-23]
- This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical development.
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