A convenient synthesis of sulfonamides and sulfonyl azides from thiols is described. In situ preparation of sulfonyl chlorides from thiols is accomplished by oxidation with N-chlorosuccinimide (NCS), tetrabutylammonium c...
An efficient approach for the preparation of novel CF(3)-substituted cyclic alpha-amino acid derivatives fused with cyclobutene ring has been developed. The method is based on intramolecular thermal [2+2] cycloaddition o...
The amination of 2-chloropyrimidines was performed with several aniline derivatives in the presence of tolylzinc bromide as a base. The organozinc compound has a profound effect on the reactivity of the amines, so that t...
Biaryl derivatives have been prepared by utilizing cross-enyne metathesis, Diels-Alder reaction followed by aromatization. These biaryl derivatives are further functionalized via Suzuki-Miyaura cross-coupling reaction to...
CO(2) gas trapped with a primary or secondary amine as a carbamate salt in the presence of DBU reacts with triphenylphosphine and 1-chlorobenzotriazole (BtCl) to form a carbamoylbenzotriazole urea, which reacts with para...
The biomimetic synthesis of the natural product 2,5-bis(3-indolylmethyl)pyrazine (11) is described. The 2,5-disubstituted pyrazine was constructed by the novel biomimetic cyclization of a tryptophan-derived amino aldehyd...
An enantiospecific synthesis of the angular triquinane system present in the sesquiterpenes cameroonanes and silphiperfolanes has been accomplished, starting from 5-isopropenyl-2-methylcyclopent-1-ene-1-methanol [readily...
beta,gamma-Unsaturated-alpha-aminophosphonates are prepared in enantiomerically enriched form via organocatalytic aldehyde alpha-sulfenylation/olefination followed by oxaziridine-mediated sulfimidation and sulfimide [2,3...
In highly nonpolar media both 1-adamantyl and 1-diamantyl triflates are sufficiently stable to react with nucleophiles in a controlled manner. Several tertiary phosphonium triflate salts with a single adamantyl or diaman...
Aryl enones undergo selective 1,4-reduction to the corresponding saturated ketones with two equivalents of tributyltin hydride in the presence of a wide range of other potentially reducible functional groups, including a...
A practical and efficient stereoselective synthesis of 3-deoxy-D-manno-2-octulosonic acid (Kdo) glycoside was achieved using N-trifluoroacetoimidate as the glycosyl donor with both batch and microfluidic methods. The met...
A highly efficient oxidation of propargylic alcohols to ynones was catalyzed by copper nanoparticles (Cu Nps) with TBHP as an oxidant at room temperature. With bipyridine as the ligand, the reaction was accelerated signi...
An efficient one-pot approach for the synthesis of highly substituted pyrrolocoumarin, quinolone, and pyrrolopyridine derivatives has been achieved by palladium acetate catalyzed reaction in DMF through initially formed ...
A highly regioselective ortho arylation of N-(2- benzoylphenyl)benzamides has been achieved with aryl iodides in the presence of 10 mol% Pd(OAc)(2) and a stoichiometric amount of AgOAc under solvent-free conditions via C...
Fe(acac)(3)/TBAOH-catalyzed three-component coupling- cycloisomerization reaction of aldehydes, terminal alkynes, and amines provides a diverse range of heterocyclic compounds such as aminoindolizines and quinoline deriv...
An efficient entry to aromatic amides using microwave irradiation in aqueous medium is described. Starting from substituted anilines, in situ formation of the corresponding aromatic azide is followed by their immediate r...