Stereoselective Glycosylation of 3-Deoxy-D-manno-2-octulosonic Acid with Batch and Microfluidic Methods

[摘要]：A practical and efficient stereoselective synthesis of 3-deoxy-D-manno-2-octulosonic acid (Kdo) glycoside was achieved using N-trifluoroacetoimidate as the glycosyl donor with both batch and microfluidic methods. The method used a conformationally constrained glycosyl donor, which has a bulky isopropylidene group at the 4,5-O-position. The strained conformation directed the coordination of the acetonitrile solvent, which led to the enhancement of reactivity and alpha-selectivity in the glycosylation.

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