- Evaluation and Implementation of a Commercially Available Mass-Guided SFC Purification Platform in a High Throughput Purification Laboratory in Drug Discovery
[作者:McClain, RT; Dudkina, A; Barrow, J; Hartman, G; Welch, CJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:483-499 , 文章类型: Article,,卷期:2009年32-4]
The evaluation and implementation of a commercially available, off the shelf, analytical SFC/MS and a mass directed, semi-preparative SFC-MS system for use in a high throughput purification laboratory is described. Th...
- Determination of Patulin in Apple Products using HPLC with Photodiode Array Detector and Ultra Performance Liquid Chromatography with Electrospray-Tandem Mass Spectrometry
[作者:Rosinska, D; Vierikova, M; Lehotay, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:500-511 , 文章类型: Article,,卷期:2009年32-4]
The mycotoxin, patulin (4-hydroxy-4H-furo[3,2c] pyran-2[6H]-one), is produced by a number of fungi common to fruit- and vegetable-based products, most notably, apples. A rapid, simple, and economical method was descri...
- Development and Validation of HPLC Assay of a New Molecule, 6-methyl-3-phenethyl-3, 4-dihydro-1H-quinazoline-2-thione from Solid Lipid Nanoparticles and its Topical Formulations
[作者:Park, H; Jung, SH; Kim, DC; Shin, SC; Cho, CW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:512-525 , 文章类型: Article,,卷期:2009年32-4]
A rapid and sensitive high performance liquid chromatography (HPLC) method has been developed and validated for the quantitative determination of a new molecule, 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thion...
- LC and LC-MS Evaluation of Stress Degradation Behavior of Carvedilol
[作者:Lanzanova, FA; Argenta, D; Arend, MZ; Brum, L; Cardoso, SG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:526-543 , 文章类型: Article,,卷期:2009年32-4]
In the present study, forced and accelerated degradation studies of carvedilol (CAR) were carried out according to ICH guideline Q1A (R2). The drug was subjected to acid (1.0N HCl), alkaline (1.0N NaOH), and neutral h...
- Analytical Evaluation of Visualizing Reagents used to Detect Ibuprofen on Thin Layers
[作者:Pyka, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:578-588 , 文章类型: Article,,卷期:2009年32-4]
Six dyes as new visualizing reagents, namely, gentian violet, methylene violet, methylene blue, methyl green, malachite green, and Janus blue, have been used to detect ibuprofen on silica gel 60F254. Rhodamine B was u...
- Extraction Methods of 10-Deacetylbaccatin III, Paclitaxel, and Cephalomannine from Taxus baccata L. Twigs: A Comparison
[作者:Wianowska, D; Hajnos, ML; Dawidowicz, AL; Oniszczuk, A; Waksmundzka-Hajnos, M; Glowniak, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:589-601 , 文章类型: Article,,卷期:2009年32-4]
Four types of solvent extraction methods (ultrasound and microwave assisted extraction, pressurized liquid extraction, and extraction in the Soxhlet apparatus) for paclitaxel, cephalomannine, and 10-deacetylbaccatin, ...
- Separation of Tanshinone I, Tanshinone IIA, and Cryptotanshinone from Salvia miltiorrhiza Bunge by Normal Phase HPLC
[作者:Wan, XL; Wang, Y; Row, KH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:544-552 , 文章类型: Article,,卷期:2009年32-4]
A normal phase high performance liquid chromatographic method was established for the simultaneous determination of tanshinones in Salvia miltiorrhiza Bunge. Tanshinones, including cryptotanshinone, tanshinone I, and ...
- Arabinose, Fucose, Ribodesose, Lyxose, and Ribose Used as Chiral Stationary Phases in HPLC
[作者:Sun, WZ; Yuan, LM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:553-559 , 文章类型: Article,,卷期:2009年32-4]
In this paper, we present the first enantioseparations using arabinose, ribose, ribodesose, lyxose, and fucose as chiral selector bonded to silica gel via 3-(triethoxysilyl)propyl isocyanate in HPLC. These chiral stat...
- Simultaneous Densitometric Determination of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol in Some Commercial Gingers
[作者:Melianita, F; Witha, J; Arifin, S; Kartinasari, WF; Indrayanto, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:567-577 , 文章类型: Article,,卷期:2009年32-4]
A simple and rapid densitometric method has been developed for determination of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in some commercial gingers. After extracting the samples four times with methanol, the...
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