- P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine
[作者:Sun, J; Khalid, S; Rozakis-Adcock, M; Fantus, IG; Jin, T,期刊:Oncogene, 页码:3132-3144 , 文章类型: Article,,卷期:2009年28-35]
- Hyperinsulinemia and type II diabetes are associated with an increased risk of developing colorectal tumors. We found previously that in intestinal cells, insulin or insulin-like growth factor-1 stimulates c-Myc and cycl...
- SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis
[作者:Oh, J; Hur, MW; Lee, CE,期刊:Oncogene, 页码:3145-3156 , 文章类型: Article,,卷期:2009年28-35]
- Suppressors of cytokine signaling (SOCS) are negative regulators of cytokine-induced signal transduction, which play multiple roles in cell growth, differentiation and apoptosis. In this study, the regulatory role of SOC...
- The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
[作者:Peschiaroli, A; Scialpi, F; Bernassola, F; Pagano, M; Melino, G,期刊:Oncogene, 页码:3157-3166 , 文章类型: Article,,卷期:2009年28-35]
- The transcription factor p73, a member of the p53 family, mediates cell-cycle arrest and apoptosis in response to DNA damage-induced cellular stress, acting thus as a proapoptotic gene. Similar to p53, p73 activity is re...
- Caspase-2: killer, savior and safeguard-emerging versatile roles for an ill-defined caspase
[作者:Krumschnabel, G; Manzl, C; Villunger, A,期刊:Oncogene, 页码:3093-3096 , 文章类型: Review,,卷期:2009年28-35]
- Despite the early discovery of caspase-2, its physiological function has long remained an enigma. A number of recent publications now suggest not just one, but multiple functions, including roles in apoptosis, DNA repair...
- Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8
[作者:Hacker, S; Dittrich, A; Mohr, A; Schweitzer, T; Rutkowski, S; Krauss, J; Debatin, KM; Fulda, S,期刊:Oncogene, 页码:3097-3110 , 文章类型: Article,,卷期:2009年28-35]
- Evasion of apoptosis can be caused by epigenetic silencing of caspase-8, a key component of the extrinsic apoptosis pathway. Loss of caspase-8 correlates with poor prognosis in medulloblastoma, which highlights the relev...
- Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines
[作者:Swartling, FJ; Ferletta, M; Kastemar, M; Weiss, WA; Westermark, B,期刊:Oncogene, 页码:3121-3131 , 文章类型: Article,,卷期:2009年28-35]
- Earlier we used a glioma model to identify loci in the mouse genome, which were repeatedly targeted by platelet-derived growth factor (PDGF)-containing Moloney murine leukemia viruses. The gene Prkg2, encoding cyclic gua...
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