The prevalence of type 2 diabetes is rapidly increasing and currently available medications for the treatment of type 2 diabetes are commonly associated with secondary failure. Alogliptin (SYR-322), a potent, highly s...

Liraglutide (NN-2211), a novel glucagon-like peptide-1 (GLP-1) analogue for once-daily s.c. injection, is in advanced clinical phase III development for type 2 diabetes therapy. It is a GLP-1 derivative with two amino...

PI-88 (phosphomannopentaose sulfate) is a mixture of sulfated oligosaccharides prepared by hydrolysis of the extracellular phosphomannan produced from the yeast Pichia holstii. It is the only heparanase inhibitor to d...

Sinecatechins (kunecatechins, Polyphenon(R) E) is an extract from green tea (Camellia sinensis) formulated in a 15% ointment. Sinecatechins contain catechins, in particular epigallocatechin gallate, which has shown po...

Potassium channels are an extensive family of ion channels selectively permeable to potassium ions (K+). They serve important functions in many crucial physiological processes and their dysregulation is key in several...

Recent clinical trials with anti-interleukin (IL)-12p40 antibodies in psoriasis and Crohn's disease patients have demonstrated the therapeutic efficacy of this approach and have validated IL-12/IL-23 as an attractive ...

Upon bacterial infection, the release of lipopolysaccharide (LIPS) endotoxin from Gram-negative bacterial membranes triggers the production of large quantities of cytokines in the body, which can lead to septic shock ...

Hepatocellular carcinoma (HCC) is still an incurable disease and one of the most common malignant cancers worldwide, often associated with an extremely poor prognosis. Many staging systems have been proposed in order ...

Dupuytren's contracture is a rare fibroproliferative disorder of the tissue beneath the palm of the hand that leads to finger contracture and may result in significant deformity and disability. There is no pharmacolog...

CAT-3888 (RFB4[dsFv]-PE38, BL22) is a recombinant immunotoxin consisting of disulfide bond-linked Fv fragments of the parental anti-CD22 monoclonal antibody RFB4 fused to PE38, a truncated form of the bacterial Pseudo...