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[摘要]：CAT-3888 (RFB4[dsFv]-PE38, BL22) is a recombinant immunotoxin consisting of disulfide bond-linked Fv fragments of the parental anti-CD22 monoclonal antibody RFB4 fused to PE38, a truncated form of the bacterial Pseudomonas exotoxin A. Following binding to CD22, this immunotoxin is internalized into the target cell by endocytosis, where it is processed to generate a free toxin fragment which, after translocation into the cytoplasm, induces cell death by catalytic inactivation of elongation factor 2 (EF-2). Since many B-cell malignancies express the CD22 antigen on their cell surface, CAT-3888 is intended to treat patients with such cancers. Indeed, initial clinical evaluation demonstrated efficacy in the treatment of chemoresistant hairy cell leukemia. |
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