This paper describes the development of an efficient and atom-economic asymmetric inverse-electron-demand hetero-Diels-Alder reaction of six-membered ketones with beta, gamma-unsaturated alpha-keto esters via enamine-met...
Synthesis and characterization of a new type of Lewis acid, rare earth metal perfluorooctanoate, as well as the recent development of multicomponent condensation reactions catalyzed by rare earth metal perfluorooctanoate...
Since the first report in 1991 of the regio- and stereoselective allylation of carbonyl compounds with allylic barium reagents, various barium reagents have been utilized in organic transformations. This account focuses ...
The preparation of optically active morpholine-2-aryl-2-acetaldehyde from morpholine-2-aryl-3-one is reported. The quaternary carbon is introduced during a palladium-promoted asymmetric allylic alkylation. This is a usef...
Allylic sulfones are excellent precursors of aryl sulfones via a new Pd-catalyzed domino sequence involving in situ generation of sulfinate anions and subsequent cross-coupling with aryl iodides or bromides.
[MeC(OH)(2)](+)ClO(4)(-) as a super acidic ionic liquid is found to be a new and highly efficient catalyst in the synthesis of amidoalkyl naphthols via three-component condensation of beta-naphthol and aldehydes with nit...
Aldehydes undergo smooth cyclization with 4-(phenylthio)but-3-en-1-ol in the presence of BF(3)center dot OEt(2) in dichloromethane at room temperature to afford a novel class of 2,3-disubstitued tetrahydrofurans in good ...
New syntheses of novel 1,2-pyrrolo[3,2-c] quinolines were established using 4-chloro-3-iodoquinoline as a synthon. The approach involved a palladium-catalyzed Sonogashira reaction of 4-chloro-3-iodoquinoline with appropr...
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. During the course of studies aimed at the identification of a suitable mPGES-1 inhibitor for clin...
Palladium-catalyzed Heck couplings between 5-iodouridine and alkenes were carried out in aqueous media in the presence of triethylamine under phosphine-free conditions to give the desired products in high yields. In the ...
The aza-Claisen rearrangement of the enolate of N-(Z)-crotyl- N-(S)-phenethylpropanamide did not proceed in the presence of 1.5 equivalents of LHMDS as a base. However, the use of a large excess of base (10 equiv) promot...
A simple and efficient procedure for carbon-carbon bond formation has been developed starting from alcohols and active methylene-containing compounds using silica gel supported sodium hydrogen sulfate (NaHSO(4)/SiO(2)) u...
A TMSOTf-promoted cycloaddition of N-benzoyl-N, O-acetals with allyl silanes to synthesize silicon-containing oxazines with high diastereoselectivities has been developed. The obtained products might be useful as buildin...
The asymmetric nitro-Mannich reactions of nitroalkanes and in situ generated N-Boc-imines were achieved with a new type of thiourea-guanidine bifunctional organocatalyst. The novel transformations exhibited good diastere...
Non-cross-linked and cross-linked bifunctional polystyrenes bearing both amine and thiourea groups have been synthesized and used as organocatalysts in reactions between nitroalkenes and nitroalkanes or sulfur ylides. Co...
An iron-mediated direct cyanation of indole and 2-arylpyridine C-H bonds is described. Notably, trimethoxybenzene reacted smoothly under the procedure, forming a C-CN bond via C-H bond cleavage without chelation assistan...