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  • Alendronate Inhibits Growth of High-grade Chondrosarcoma Cells
    [作者:Susa, M; Morii, T; Yabe, H; Horiuchi, K; Toyama, Y; Weissbach, L; Hornicek, FJ; Morioka, H,期刊:Anticancer Research, 页码:1879-1888 , 文章类型: Article,,卷期:2009年29-6]
  • Background: Conventional chemotherapy is ineffective for high-grade chondrosarcomas, highlighting the need for improved chemotherapies. Various clinical trials have been initiated using antiapoptotic agents and perifosin...
  • Combination of PI3K/mTOR Inhibition Demonstrates Efficacy in Human Chordoma
    [作者:Schwab, J; Antonescu, C; Boland, P; Healey, J; Rosenberg, A; Nielsen, P; Iafrate, J; Delaney, T; Yoon, S; Choy, E; Harmon, D; Raskin, K; Yang, C; Mankin, H; Springfield, D; Hornicek, F; Duan, ZF,期刊:Anticancer Research, 页码:1867-1871 , 文章类型: Article,,卷期:2009年29-6]
  • Background: Chordomas are rare tumors of the axial skeleton for which surgical resection remains the most reliable means of cure. PI-103 is a inhibitor of PI3K/AKT and mTOR activation. This study aims to determine whethe...
  • Expression of Bone Morphogenetic Proteins in Giant Cell Tumor of Bone
    [作者:Kudo, N; Ogose, A; Ariizumi, T; Kawashima, H; Hotta, T; Hatano, H; Morita, T; Nagata, M; Siki, Y; Kawai, A; Hotta, Y; Hoshino, M; Endo, N,期刊:Anticancer Research, 页码:2219-2225 , 文章类型: Article,,卷期:2009年29-6]
  • Background: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence. A characteristic pattern of peripheral bone formation has been described in GCT recurrence in soft tissue...
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