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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   ELISIDEPSIN Antineoplastic Agent [作者：Coronado, C; Galmarini, CM; Alfaro, V; Yovine, A,期刊：Drugs of the Future, 页码：287-296 , 文章类型： Article，,卷期：2010年35-4] Elisidepsin (Irvalec(R), PM02734) is a depsipeptide produced by chemical synthesis and chosen for development as an antineoplastic agent based on its in vitro activity against human solid tumor cell lines, in vivo activi... CIXUTUMUMAB Anti-CD221 Human Monoclonal Antibody Angiogenesis Inhibitor Oncolytic [作者：Rowinsky, EK; Schwartz, JD; Zojwalla, N; Youssoufian, H; Fox, F; Pultar, P; Ludwig, DL,期刊：Drugs of the Future, 页码：265-285 , 文章类型： Article，,卷期：2010年35-4] The use of monoclonal antibodies (mAbs) against cancer targets has been validated as a therapeutic strategy, due in part to the ability of antibodies to induce robust structural and functional perturbations with negligib... ACTIVE IMMUNOTHERAPY FOR THE TREATMENT OF COCAINE DEPENDENCE [作者：Kinsey, BM; Orson, FM; Kosten, TR,期刊：Drugs of the Future, 页码：301-306 , 文章类型： Review，,卷期：2010年35-4] Although cocaine is illegal in most countries of the world, addiction is common and increasing in many populations, and the effectiveness of current treatment options for those afflicted has been very limited. The availa... RECENT DEVELOPMENTS IN METABOTROPIC GLUTAMATE RECEPTORS AS NOVEL DRUG TARGETS [作者：O'Neill, MJ; Fell, MJ; Svensson, KA; Witkin, JM; Mitchell, SN,期刊：Drugs of the Future, 页码：307-324 , 文章类型： Review，,卷期：2010年35-4] Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system, activating ionotropic (iGlu) and metabotropic (mGlu) glutamate receptors. Targeting iGlu receptors has proven difficult, as thes... rhGAD65 Diabetes Vaccine [作者：Ferrer, E,期刊：Drugs of the Future, 页码：297-299 , 文章类型： Article，,卷期：2010年35-4] Therapeutic vaccines have emerged as a promising alternative in the prevention and treatment of autoimmune diabetes, a progressive autoimmune destruction of insulin-producing beta-cells in the pancreas. Thus, using autoa... TRANSTHYRETIN AMYLOIDOSES: NEW STRATEGIES FOR THERAPEUTIC INTERVENTION [作者：Suhr, OB; Lundgren, E; Westermark, P,期刊：Drugs of the Future, 页码：325-332 , 文章类型： Article，,卷期：2010年35-4] Liver transplantation as a treatment for transthyretin amyloidosis (ATTR) was introduced 20 years ago and is currently the only available treatment for the disease. Although the procedure has been proven to halt the prog... THERAPEUTIC TARGETS FOR GOUT [作者：Sorbera, LA; Sharanya, S; Dulsat, C; Rosa, E,期刊：Drugs of the Future, 页码：333-337 , 文章类型： Article，,卷期：2010年35-4] Gout is a metabolic disorder caused by hyperuricemia and consequent deposition of uric acid crystals in the joints of the lower extremities. The result is swelling, inflammation and severe pain. The main goals of gout tr... THE CUTTING EDGE OF CHEMISTRY A PHARMA MATTERS REPORT-2009 REVIEW [作者：[Anon],期刊：Drugs of the Future, 页码：339-348 , 文章类型： Article，,卷期：2010年35-4]