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[摘要]：Gout is a metabolic disorder caused by hyperuricemia and consequent deposition of uric acid crystals in the joints of the lower extremities. The result is swelling, inflammation and severe pain. The main goals of gout treatment are to manage the intense pain accompanying acute attacks and to arrest disease progression. Acute attacks are usually treated with nonsteroidal anti-inflammatory drugs (NSAIDs) or oral glucocorticoids. Treatment is also aimed at controlling uric acid levels and preventing the formation of new tophi. Several therapeutic strategies are available to patients suffering from gout and they include uricosuric agents, xanthine oxidase inhibitors, recombinant uricase preparations and anti-inflammatory agents. Researchers continue to search for more effective treatment strategies for gout with investigations concentrating on identifying novel targets for therapeutic intervention. This article presents those drug targets that are currently under active investigation for the treatment of gout. |
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