- Garcinia Xanthones as Orally Active Antitumor Agents
[作者:ZHAN XIAOJIN; LI XIANG; SUN HAOPENG; WANG XIAOJIAN; ZHAO LI; GAO YUAN; LIU XIAORONG; ZHANG SHENGLIE; WANG YANYAN; YANG YINGRUI; ZENG SU; GUO QINGLONG; YOU QIDONG,期刊:Journal of Medicinal Chemistry, 页码:276-292 , 文章类型: Article,,卷期:2013年56-1]
- Using a newly developed strategy whose key step is the regioselective propargylation of hydroxyxanthone substrates, 99 structurally diverse Garcinia natural-product-like xanthones based on gambogic acid were designed and...
- Design and Synthesis of Diazatricyclodecane Agonists of the G-Protein-Coupled Receptor 119
[作者:DAROUT ETZER; ROBINSON RALPH P; MCCLURE KIM F; CORBETT MATTHEW; LI BRYAN; SHAVNYA ANDREI; ANDREWS MELISSA P; JONES CHRISTOPHER S; LI QIFANG; MINICH MARTHA L; MASCITTI VINCENT; GUIMARAES CRISTIANO R W; MUNCHHOF MICHAEL J; BAHNCK KEVIN B; CAI CUIMAN; PRICE DAVID A; LIRAS SPIROS; BONIN PAUL D; CORNELIUS PETER; WANG RUDUAN; BAGDASARIAN VICTORIA; SOBOTA COLLEEN P; HORNBY SAM; MASTERSON VICTORIA M; JOSEPH REENA M; KALGUTKAR AMIT S; CHEN YUE,期刊:Journal of Medicinal Chemistry, 页码:301-319 , 文章类型: Article,,卷期:2013年56-1]
- A series of GPR119 agonists based on a 2,6-diazatricyclo[3.3.1.1 similar to 3,7,similar to]decane ring system is described. Also provided is a detailed account of the development of a multigram scale synthesis of the dia...
- Peptide-Conjugated Pterins as Inhibitors of Ricin Toxin A
[作者:SAITO RYOTA; PRUET JEFF M; MANZANO LAWRENCE A; JASHEWAY KARL; MONZINGO ARTHUR F; WIGET PAUL A; KAMAT ISHAN; ANSLYN ERIC V; ROBERTUS JON D,期刊:Journal of Medicinal Chemistry, 页码:320-329 , 文章类型: Article,,卷期:2013年56-1]
- Several 7-peptide-substituted pterins were synthesized and tested as competitive active-site inhibitors of ricin toxin A (RTA). Focus began on dipeptide conjugates, and these results further guided the construction of se...
- 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models
[作者:SOTH MICHAEL; HERMANN JOHANNES C; YEE CALVIN; ALAM MUZAFFAR; BARNETT JIM W; BERRY PAMELA; BROWNER MICHELLE F; FRANK KARL; FRAUCHIGER SANDRA; HARRIS SETH; HE YANG; HEKMATNEJAD MOHAMMAD; HENDRICKS THAN; HENNINGSEN ROBERT; HILGENKAMP RAMONA; HO HOANGDUNG; HOFFMAN ANN; HSU PEIYUAN; HU DONGQING; ITANO ANDREA; JAIMEFIGUEROA SAUL; JAHANGIR ALAM; JIN SUE; KUGLSTATTER ANDREAS; KUTACH ALAN K; LIAO CHENG; LYNCH STEPHEN; MENKE JOHN; NIU LINGHAO; PATEL VAISHALI; RAILKAR ARUNA; ROY DOUGLAS; SHAO ADA; SHAW DAVID; STEINER SANDRA; SUN YONGLIANG; TAN SENGLAI; WANG SANDRA; MINH DIEM VU,期刊:Journal of Medicinal Chemistry, 页码:345-356 , 文章类型: Article,,卷期:2013年56-1]
- The Janus kinases (JAKs) are involved in multiple signaling networks relevant to inflammatory diseases, and inhibition of one or more members of this class may modulate disease activity or progression. We optimized a new...
- Development of Vizantin, a Safe Immunostimulant, Based on the Structure-Activity Relationship of Trehalose-6,6 '-dicorynomycolate
[作者:YAMAMOTO HIROFUMI; ODA MASATAKA; NAKANO MAYO; WATANABE NAOYUKI; YABIKU KENTA; SHIBUTANI MASAHIRO; INOUE MASAHISA; IMAGAWA HIROSHI; NAGAHAMA MASAHIRO; HIMENO SEIICHIRO; SETSU KOJUN; SAKURAI JUN; NISHIZAWA MUGIO,期刊:Journal of Medicinal Chemistry, 页码:381-385 , 文章类型: Article,,卷期:2013年56-1]
- Vizantin, 6,6'-bis-O-(3-nonyldodecanoy1)-alpha,alpha'-trehalose, was developed as a safe immunostimulator on the basis of a structure-activity relationship (SAR) study with trehalose 6,6'-dicorynomycolate (TDCM). It was ...
|