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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共43条记录   Oligonucleotide microarrays with stem-loop probes: Enhancing the hybridization of nucleic acids for sensitive analysis [作者：Mahajan, S; Swami, A; Sethi, D; Kumar, P; Gupta, KC,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3585-3588 , 文章类型： Article，,卷期：2008年18-12] We have demonstrated that the dynamics of nucleic acid hybridization in microarrays depend on the physical structure of immobilized probes. We have immobilized oligonucleotide-3'-phosphates with and without stem-loop str... Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity [作者：Chang, HW; Jang, KH; Lee, D; Kang, HR; Kim, TY; Lee, BH; Choi, BW; Kim, S; Shin, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3589-3592 , 文章类型： Article，,卷期：2008年18-12] Polyunsaturated fatty acid-derived monoglycerides were characterized from the marine brown alga Sargassum sagamianum, collected from Jeju Island, Korea. A new compound of this structural class was isolated and determined... Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols [作者：Innocenti, A; Hilvo, M; Scozzafava, A; Parkkila, S; Supuran, CT,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3593-3596 , 文章类型： Article，,卷期：2008年18-12] Inhibition of the newest isoform of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), CA XV, with a series of phenols was investigated. Murine CA XV showed an inhibition pro. le by phenols distinct of those of the c... C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I [作者：Wang, YF; Ng, MTT; Zhou, TY; Li, XM; Tan, CH; Li, TH,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3597-3602 , 文章类型： Article，,卷期：2008年18-12] Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as r... Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway [作者：Lohar, MV; Mundada, R; Bhonde, M; Padgaonkar, A; Deore, V; Yewalkar, N; Bhatia, D; Rathos, M; Joshi, K; Vishwakarma, RA; Kumar, S,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3603-3606 , 文章类型： Article，,卷期：2008年18-12] We herein report the design and synthesis of furoquinoline based novel molecules (16-36) and their in vitro multiple targeted inhibitory potency against PI3K/Akt phosphorylation and mTOR using cell based and cell-free ki... Analogues of N-hydroxy-N '-phenylthiourea and N-hydroxy-N '-phenylurea as inhibitors of tyrosinase and melanin formation [作者：Criton, M; Mellay-Hamon, V,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3607-3610 , 文章类型： Article，,卷期：2008年18-12] A series of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea analogues were prepared and evaluated as inhibitors of tyrosinase and melanin formation. The most active analogue 1 inhibited mushroom tyrosinase with a... Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha 7 nicotinic acetylcholine receptor: In vitro and in vivo activity [作者：Acker, BA; Jacobsen, EJ; Rogers, BN; Wishka, DG; Reitz, SC; Piotrowski, DW; Myers, JK; Wolfe, ML; Groppi, VE; Thornburgh, BA; Tinholt, PM; Walters, RR; Olson, BA; Fitzgerald, L; Staton, BA; Raub, TJ; Krause, M; Li, KS; Hoffmann, WE; Hajos, M; Hurst, RS; Walker, DP,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3611-3615 , 文章类型： Article，,卷期：2008年18-12] A novel alpha 7 nAChR agonist, N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide ( 3a, PHA-709829), has been identified for the potential treatment of cognitive deficits in schizophrenia. The compo... Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCVNS5B polymerase [作者：Ruebsam, F; Webber, SE; Tran, MT; Tran, CV; Murphy, DE; Zhao, JJ; Dragovich, PS; Kim, SH; Li, LS; Zhou, YF; Han, Q; Kissinger, CR; Showalter, RE; Lardy, M; Shah, AM; Tsan, M; Patel, R; LeBrun, LA; Kamran, R; Sergeeva, MV; Bartkowski, DM; Nolan, TG; Norris, DA; Kirkovsky, L,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3616-3621 , 文章类型： Article，,卷期：2008年18-12] Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3k, which displayed potent inhibitory activi... Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors [作者：Bingham, AH; Davenport, RJ; Fosbeary, R; Gowers, L; Knight, RL; Lowe, C; Owen, DA; Parry, DM; Pitt, WR,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3622-3627 , 文章类型： Article，,卷期：2008年18-12] The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported. (C) 2008 ... Structure-based optimization of a potent class of arylamide FMS inhibitors [作者：Meegalla, SK; Wall, MJ; Chen, J; Wilson, KJ; Ballentine, SK; DesJarlais, RL; Schubert, C; Crysler, CS; Chen, Y; Molloy, CJ; Chaikin, MA; Manthey, CL; Player, MR; Tomczuk, BE; Illig, CR,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3632-3637 , 文章类型： Article，,卷期：2008年18-12] An anti-inflammatory 1,2,4-phenylenetriamine-containing series of FMS inhibitors with a potential to form reactive metabolites was transformed into a series with equivalent potency by incorporation of carbon-based replac... Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs [作者：Mercer, SL; Cunningham, CW; Eddington, ND; Coop, A,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3638-3640 , 文章类型： Article，,卷期：2008年18-12] Numerous studies have shown that many clinically employed opioid analgesics are substrates for P-glycoprotein (P-gp), suggesting that up-regulation of P-gp may contribute to the development of central tolerance to opioid... Design, synthesis and evaluation of potent thymidylate synthase X inhibitors [作者：Onen, FE; Boum, Y; Jacquement, C; Spanedda, MV; Jaber, N; Scherman, D; Myllykallio, H; Herscovici, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3628-3631 , 文章类型： Article，,卷期：2008年18-12] Three synthesized series of compounds based on a thiazolidine core allowed identification of potent inhibitors of thymidylate synthase X. The evaluation of the catalytic activity of the enzyme in the presence of these mo... Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment [作者：Mayer, SC; Banker, AL; Boschelli, F; Di, L; Johnson, M; Kenny, CH; Krishnamurthy, G; Kutterer, K; Moy, F; Petusky, S; Ravi, M; Tkach, D; Tsou, HR; Xu, WX,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3641-3645 , 文章类型： Article，,卷期：2008年18-12] Insulin-like growth factor receptor (IGF-1R) is a growth factor receptor tyrosine kinase that acts as a critical mediator of cell proliferation and survival. This receptor is over-expressed or activated in tumor cells an... Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype [作者：Myers, MC; Shah, PP; Beavers, MP; Napper, AD; Diamond, SL; Smith, AB; Huryn, DM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3646-3651 , 文章类型： Article，,卷期：2008年18-12] Recently, we identified a thiocarbazate that exhibits potent inhibitory activity against human cathepsin L. Since this structure represents a novel chemotype with potential for activity against the entire cysteine protea... Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer [作者：Li, Y; Zhang, HB; Huang, WL; Li, YM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3652-3655 , 文章类型： Article，,卷期：2008年18-12] Exploration for new MDR-modulator utilizing tetrahydroisoquinoline as scaffold disclosed 6,7-dimethoxy1-(3,4-dimethoxy)benzyl-2-(N-n-octyl-N'-cyano)guanyl-1,2,3,4-tetrahydroisoquinoline (7) as a readily accessible medici... IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a] pyridines [作者：Buckley, GM; Fosbeary, R; Fraser, JL; Gowers, L; Higueruelo, AP; James, LA; Jenkins, K; Mack, SR; Morgan, T; Parry, DM; Pitt, WR; Rausch, O; Richard, MD; Sabin, V,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：3656-3660 , 文章类型： Article，,卷期：2008年18-12] Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a] pyridino-pyridines and benzimidazolo-pyridines...