C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I

[摘要]：Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes. (C) 2008 Elsevier Ltd. All rights reserved.

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