- Expansion of CD133-Expressing Liver Cancer Stem Cells in Liver-Specific Phosphatase and Tensin Homolog Deleted on Chromosome 10-Deleted Mice
[作者:Rountree, CB; Ding, W; He, L; Stiles, B,期刊:Stem Cells, 页码:290-299 , 文章类型: Article,,卷期:2009年27-2]
- PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase that regulates mitogenic signaling pathways, and deficiency of PTEN results in cell proliferation, survival, and malignancy. Murine li...
- Fibroblast-Derived Induced Pluripotent Stem Cells Show No Common Retroviral Vector Insertions
[作者:Varas, F; Stadtfeld, M; De Andres-Aguayo, L; Maherali, N; di Tullio, A; Pantano, L; Notredame, C; Hochedlinger, K; Graf, T,期刊:Stem Cells, 页码:300-306 , 文章类型: Article,,卷期:2009年27-2]
- Several laboratories have reported the reprogramming of mouse and human fibroblasts into pluripotent cells, using retroviruses carrying the Oct4, Sox2, Klf4, and c-Myc transcription factor genes. In these experiments the...
- Role of Natural-Killer Group 2 Member D Ligands and Intercellular Adhesion Molecule 1 in Natural Killer Cell-Mediated Lysis of Murine Embryonic Stem Cells and Embryonic Stem Cell-Derived Cardiomyocytes
[作者:Frenzel, LP; Abdullah, Z; Kriegeskorte, AK; Dieterich, R; Lange, N; Busch, DH; Kronke, M; Utermohlen, O; Hescheler, J; Saric, T,期刊:Stem Cells, 页码:307-316 , 文章类型: Article,,卷期:2009年27-2]
- The transplantation of cardiomyocytes derived from embryonic stem (ES) cells into infarcted heart has been shown to improve heart function in animal models. However, immune rejection of transplanted cells may hamper the ...
- Derivation and Characterization of Canine Embryonic Stem Cell Lines with In Vitro and In Vivo Differentiation Potential
[作者:Vaags, AK; Rosic-Kablar, S; Gartley, CJ; Zheng, YZ; Chesney, A; Villagomez, DAF; Kruth, SA; Hough, MR,期刊:Stem Cells, 页码:329-340 , 文章类型: Article,,卷期:2009年27-2]
- Embryonic stem cells (ESCs) represent permanent cell lines that can be maintained in an undifferentiated state. In an environment that induces differentiation, they form derivatives of the three embryonic germ layers: me...
- Biphasic Induction of Pdx1 in Mouse and Human Embryonic Stem Cells Can Mimic Development of Pancreatic beta-Cells
[作者:Bernardo, AS; Cho, CHH; Mason, S; Docherty, HM; Pedersen, RA; Vallier, L; Docherty, K,期刊:Stem Cells, 页码:341-351 , 文章类型: Article,,卷期:2009年27-2]
- Embryonic stem (ES) cells represent a possible source of islet tissue for the treatment of diabetes. Achieving this goal will require a detailed understanding of how the transcription factor cascade initiated by the home...
- Pluripotin Combined with Leukemia Inhibitory Factor Greatly Promotes the Derivation of Embryonic Stem Cell Lines from Refractory Strains
[作者:Yang, W; Wei, W; Shi, C; Zhu, JL; Ying, WQ; Shen, Y; Ye, X; Fang, LL; Duo, SG; Che, J; Shen, H; Ding, S; Deng, HK,期刊:Stem Cells, 页码:383-389 , 文章类型: Article,,卷期:2009年27-2]
- Most mouse embryonic stem (ES) cells are derived from a 129 or C57BL/6 background, whereas the derivation efficiency of ES cells is extremely low on certain refractory types of background for which ES cells are highly de...
- Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage, Reversed by Increases in pAMPK, Heme Oxygenase-1, and Adiponectin
[作者:Sambuceti, G; Morbelli, S; Vanella, L; Kusmic, C; Marini, C; Massollo, M; Augeri, C; Corselli, M; Ghersi, C; Chiavarina, B; Rodella, LF; L'Abbate, A; Drummond, G; Abraham, NG; Frassoni, F,期刊:Stem Cells, 页码:399-407 , 文章类型: Article,,卷期:2009年27-2]
- Background. Atherosclerosis progression is accelerated in diabetes mellitus (DM) by either direct endothelial damage or reduced availability and function of endothelial progenitor cells (EPCs). Both alterations are relat...
- Endogenous Hepatocyte Growth Factor Is a Niche Signal for Subventricular Zone Neural Stem Cell Amplification and Self-Renewal
[作者:Nicoleau, C; Benzakour, O; Agasse, F; Thiriet, N; Petit, J; Prestoz, L; Roger, M; Jaber, M; Coronas, V,期刊:Stem Cells, 页码:408-419 , 文章类型: Article,,卷期:2009年27-2]
- Neural stem cells persist in the adult mammalian brain, within the subventricular zone (SVZ). The endogenous mechanisms underpinning SVZ neural stem cell proliferation, self-renewal, and differentiation are not fully elu...
- A Nuclear Magnetic Resonance Biomarker for Neural Progenitor Cells: Is It All Neurogenesis?
[作者:Ramm, P; Couillard-Despres, S; Plotz, S; Rivera, FJ; Krampert, M; Lehner, B; Kremer, W; Bogdahn, U; Kalbitzer, HR; Aigner, L,期刊:Stem Cells, 页码:420-423 , 文章类型: Article,,卷期:2009年27-2]
- In vivo visualization of endogenous neural progenitor cells (NPCs) is crucial to advance stem cell research and will be essential to ensure the safety and efficacy of neurogenesis-based therapies. Magnetic resonance spec...
- Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist
[作者:Erickson-Miller, CL; Delorme, E; Tian, SS; Hopson, CB; Landis, AJ; Valoret, EI; Sellers, TS; Rosen, J; Miller, SG; Luengo, JI; Duffy, KJ; Jenkins, JM,期刊:Stem Cells, 页码:424-430 , 文章类型: Article,,卷期:2009年27-2]
- Eltrombopag is a first-in-class, orally bioavailable, small-molecule, nonpeptide agonist of the thrombopoietin receptor (TpoR), which is being developed as a treatment for thrombocytopenia of various etiologies. In vitro...
- Neurogenesis in the Dentate Gyrus Depends on Ciliary Neurotrophic Factor and Signal Transducer and Activator of Transcription 3 Signaling
[作者:Muller, S; Chakrapani, BPS; Schwegler, H; Hofmann, HD; Kirsch, M,期刊:Stem Cells, 页码:431-441 , 文章类型: Article,,卷期:2009年27-2]
- In the neurogenic areas of the adult rodent brain, neural stem cells (NSCs) proliferate and produce new neurons throughout the lifetime. This requires a permanent pool of NSCs, the size of which needs to be tightly contr...
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