- A yeast functional screen predicts new candidate ALS disease genes
[作者:Couthouis, J; Hart, MP; Shorter, J; DeJesus-Hernandez, M; Erion, R; Oristano, R; Liu, AX; Ramos, D; Jethava, N; Hosangadi, D; Epstein, J; Chiang, A; Diaz, Z; Nakaya, T; Ibrahim, F; Kim, HJ; Solski, JA; Williams, KL; Mojsilovic-Petrovic, J; Ingre, C; Boylan, K; Graff-Radford, NR; Dickson, DW; Clay-Falcone, D; Elman, L; McCluskey, L; Greene, R; Kalb, RG; Lee, VMY; Trojanowski, JQ; Ludolph, A; Robberecht, W; Andersen, PM; Nicholson, GA; Blair, IP; King, OD; Bonini, NM; Van Deerlin, V; Rademakers, R; Mourelatos, Z; Gitler, AD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20881-20890 , 文章类型: Article,,卷期:2011年108-52]
- Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative disease. Mutations in two related RNA-binding proteins, TDP-43 and FUS, that harbor prion-like domains, cause some forms of ALS...
- Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress
[作者:Bauer, M; Goldstein, M; Christmann, M; Becker, H; Heylmann, D; Kaina, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21105-21110 , 文章类型: Article,,卷期:2011年108-52]
- Monocytes are key players in the immune system. Crossing the blood barrier, they infiltrate tissues and differentiate into (i) macrophages that fight off pathogens and (ii) dendritic cells (DCs) that activate the immune ...
- Retinoblastoma (Rb) regulates laminar dendritic arbor reorganization in retinal horizontal neurons
[作者:Martins, RAP; Davis, D; Kerekes, R; Zhang, JK; Bayazitov, IT; Hiler, D; Karakaya, M; Frase, S; Gleason, S; Zakharenko, SS; Johnson, DA; Dyer, MA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21111-21116 , 文章类型: Article,,卷期:2011年108-52]
- Neuronal differentiation with respect to the acquisition of synaptic competence needs to be regulated precisely during neurogenesis to ensure proper formation of circuits at the right place and time in development. This ...
- Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice
[作者:Qin, S; Liu, ML; Niu, WZ; Zhang, CL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21117-21121 , 文章类型: Article,,卷期:2011年108-52]
- Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we sho...
- Ligand-binding properties of a juvenile hormone receptor, Methoprene-tolerant
[作者:Charles, JP; Iwema, T; Epa, VC; Takaki, K; Rynes, J; Jindra, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21128-21133 , 文章类型: Article,,卷期:2011年108-52]
- Juvenile hormone (JH) is a sesquiterpenoid of vital importance for insect development, yet the molecular basis of JH signaling remains obscure, mainly because a bona fide JH receptor has not been identified. Mounting evi...
- Genome diversity in wild grasses under environmental stress
[作者:Fitzgerald, TL; Shapter, FM; McDonald, S; Waters, DLE; Chivers, IH; Drenth, A; Nevo, E; Henry, RJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21140-21145 , 文章类型: Article,,卷期:2011年108-52]
- Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest adaptive selection at this locus. The extent to which environmental selection may act at additional nuclear-encoded defense l...
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