- An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C-elegans
[作者：Budovskaya, YV; Wu, K; Southworth, LK; Min, J; Tedesco, P; Johnson, TE; Kim, SK,期刊：Cell, 页码：291-303 , 文章类型： Article，,卷期：2008年134-2]
- To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are re...
- Superoxide flashes in single mitochondria
[作者：Wang, W; Fang, HQ; Groom, L; Cheng, AW; Zhang, WR; Liu, J; Wang, XH; Li, KT; Han, PD; Zheng, M; Yin, JH; Wang, WD; Mattson, MP; Kao, JPY; Lakatta, EG; Sheu, SS; Ouyang, KF; Chen, J; Dirksen, RT; Cheng, HP,期刊：Cell, 页码：279-290 , 文章类型： Article，,卷期：2008年134-2]
- In quiescent cells, mitochondria are the primary source of reactive oxygen species (ROS), which are generated by leakiness of the electron transport chain (ETC). High levels of ROS can trigger cell death, whereas lower l...
- Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1
[作者：Dasen, JS; De Camilli, A; Wang, B; Tucker, PW; Jessell, TM,期刊：Cell, 页码：304-316 , 文章类型： Article，,卷期：2008年134-2]
- The precision with which motor neurons innervate target muscles depends on a regulatory network of Hox transcription factors that translates neuronal identity into patterns of connectivity. We show that a single transcri...
- The NAD(+)-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
[作者：Nakahata, Y; Kaluzova, M; Grimaldi, B; Sahar, S; Hirayama, J; Chen, D; Guarente, LP; Sassone-Corsi, P,期刊：Cell, 页码：329-340 , 文章类型： Article，,卷期：2008年134-2]
- Circadian rhythms govern a large array of metabolic and physiological functions. The central clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, a...
- SIRT1 regulates circadian clock gene expression through PER2 deacetylation
[作者：Asher, G; Gatfield, D; Stratmann, M; Reinke, H; Dibner, C; Kreppel, F; Mostoslavsky, R; Alt, FW; Schibler, U,期刊：Cell, 页码：317-328 , 文章类型： Article，,卷期：2008年134-2]
- The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus of the brain that synchronizes countless subsidiary oscillators in peripheral tissues. The rhythm-generating mechani...
- SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function
[作者：Kruger, M; Moser, M; Ussar, S; Thievessen, I; Luber, CA; Forner, F; Schmidt, S; Zanivan, S; Fassler, R; Mann, M,期刊：Cell, 页码：353-364 , 文章类型： Article，,卷期：2008年134-2]
- Stable isotope labeling by amino acids in cell culture (SILAC) has become a versatile tool for quantitative, mass spectrometry (MS)-based proteomics. Here, we completely label mice with a diet containing either the natur...
- Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency (vol 133, pg 250, 2008)
[作者：Hanna, J; Markoulaki, S; Schorderet, P; Carey, BW; Beard, C; Wernig, M; Creyghton, MP; Steine, EJ; Cassady, JP; Foreman, R; Lengner, CJ; Dausman, JA; Jaenisch, R,期刊：Cell, 页码：365-365 , 文章类型： Correction，,卷期：2008年134-2]
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- TGF beta in cancer
[作者：Massague, J,期刊：Cell, 页码：215-230 , 文章类型： Review，,卷期：2008年134-2]
- The transforming growth factor beta (TGF beta) signaling pathway is a key player in metazoan biology, and its misregulation can result in tumor development. The regulatory cytokine TGF beta exerts tumor-suppressive effec...
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