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Costly mistakes: Translational infidelity and protein homeostasis

  作者 Powers, ET; Balch, WE  
  选自 期刊  Cell;  卷期  2008年134-2;  页码  204-206  
  关联知识点  
 

[摘要]Protein misfolding is increasingly being recognized as a key process in organismal health and disease. Drummond and Wilke (2008) show that misfolding caused by mistakes during the translation of RNA into proteins (mistranslation) also results in a strong selection pressure to optimize translational fidelity, especially for proteins that are highly expressed.

 
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