- Nf1-Dependent Tumors Require a Microenvironment Containing Nf1(+/-) and c-kit-Dependent Bone Marrow
[作者：Yang, FC; Ingram, DA; Chen, S; Zhu, Y; Yuan, J; Li, XH; Yang, XL; Knowles, S; Horn, W; Li, Y; Zhang, SB; Yang, YZ; Vakili, ST; Yu, MG; Burns, D; Robertson, K; Hutchins, G; Parada, LF; Clapp, DW,期刊：Cell, 页码：437-448 , 文章类型： Article，,卷期：2008年135-3]
- Interactions between tumorigenic cells and their surrounding microenvironment are critical for tumor progression yet remain incompletely understood. Germline mutations in the NF1 tumor suppressor gene cause neurofibromat...
- RNase P without RNA: Identification and Functional Reconstitution of the Human Mitochondrial tRNA Processing Enzyme
[作者：Holzmann, J; Frank, P; Loffler, E; Bennett, KL; Gerner, C; Rossmanith, W,期刊：Cell, 页码：462-474 , 文章类型： Article，,卷期：2008年135-3]
- tRNAs are synthesized as immature precursors, and on their way to functional maturity, extra nucleotides at their 50 ends are removed by an endonuclease called RNase P. All RNase P enzymes characterized so far are compos...
- The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells
[作者：Chou, YF; Chen, HH; Eijpe, M; Yabuuchi, A; Chenoweth, JG; Tesar, P; Lu, J; McKay, RDG; Geijsen, N,期刊：Cell, 页码：449-461 , 文章类型： Article，,卷期：2008年135-3]
- Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic stem cell lines (ES cells), as well as the postimplantation epiblast, which gives rise to epiblast stem cell lines (EpiSCs). Remar...
- The MatP/matS Site-Specific System Organizes the Terminus Region of the E-coli Chromosome into a Macrodomain
[作者：Mercier, R; Petit, MA; Schbath, S; Robin, S; El Karoui, M; Boccard, F; Espeli, O,期刊：Cell, 页码：475-485 , 文章类型： Article，,卷期：2008年135-3]
- The organization of the Escherichia coli chromosome into insulated macrodomains influences the segregation of sister chromatids and the mobility of chromosomal DNA. Here, we report that organization of the Terminus regio...
- Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
[作者：Sanz-Moreno, V; Gadea, G; Ahn, J; Paterson, H; Marra, P; Pinner, S; Sahai, E; Marshall, CJ,期刊：Cell, 页码：510-523 , 文章类型： Article，,卷期：2008年135-3]
- Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type movement is characterized by an elongated cellular morphology and requires extracellular proteolysis. In amoeboid movement, cells have...
- An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs
[作者：Chari, A; Golas, MM; Klingenhager, M; Neuenkirchen, N; Sander, B; Englbrecht, C; Sickmann, A; Stark, H; Fischer, U,期刊：Cell, 页码：497-509 , 文章类型： Article，,卷期：2008年135-3]
- Spliceosomal small nuclear ribonucleoproteins (snRNPs) are essential components of the nuclear pre-mRNA processing machinery. A hallmark of these particles is a ring-shaped core domain generated by the binding of Sm prot...
- Myosin Vb Mobilizes Recycling Endosomes and AMPA Receptors for Postsynaptic Plasticity
[作者：Wang, ZP; Edwards, JG; Riley, N; Provance, DW; Karcher, R; Li, XD; Davison, IG; Ikebe, M; Mercer, JA; Kauer, JA; Ehlers, MD,期刊：Cell, 页码：535-548 , 文章类型： Article，,卷期：2008年135-3]
- Learning-related plasticity at excitatory synapses in the mammalian brain requires the trafficking of AMPA receptors and the growth of dendritic spines. However, the mechanisms that couple plasticity stimuli to the traff...
- Undertaker, a Drosophila Junctophilin, Links Draper-Mediated Phagocytosis and Calcium Homeostasis
[作者：Cuttell, L; Vaughan, A; Silva, E; Escaron, CJ; Lavine, M; Van Goethem, E; Eid, JP; Quirin, M; Franc, NC,期刊：Cell, 页码：524-534 , 文章类型： Article，,卷期：2008年135-3]
- Phagocytosis is important during development and in the immune response for the removal of apoptotic cells and pathogens, yet its molecular mechanisms are poorly understood. In Caenorhabditis elegans, the CED2/5/10/12 pa...
- Anatomical Profiling of G Protein-Coupled Receptor Expression
[作者：Regard, JB; Sato, IT; Coughlin, SR,期刊：Cell, 页码：561-571 , 文章类型： Article，,卷期：2008年135-3]
- G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane signaling molecules and regulate a host of physiological and disease processes. To better understand the functions of GPCRs in vivo, we qua...
- Autism: Many Genes, Common Pathways?
[作者：Geschwind, DH,期刊：Cell, 页码：391-395 , 文章类型： Editorial Material，,卷期：2008年135-3]
- Autism is a heterogeneous neurodevelopmental syndrome with a complex genetic etiology. It is still not clear whether autism comprises a vast collection of different disorders akin to intellectual disability or a few diso...
- Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning
[作者：Cui, YJ; Costa, RM; Murphy, GG; Elgersma, Y; Zhu, Y; Gutmann, DH; Parada, LF; Mody, I; Silva, AJ,期刊：Cell, 页码：549-560 , 文章类型： Article，,卷期：2008年135-3]
- We uncovered a role for ERK signaling in GABA release, long-term potentiation (LTP), and learning, and show that disruption of this mechanism accounts for the learning deficits in a mouse model for learning disabilities ...
- Autism and Brain Development
[作者：Walsh, CA; Morrow, EM; Rubenstein, JLR,期刊：Cell, 页码：396-400 , 文章类型： Editorial Material，,卷期：2008年135-3]
- Genetic studies are refining our understanding of neurodevelopmental mechanisms in autism. Some autism-related mutations appear to disrupt genes regulated by neuronal activity, which are especially important in developme...
- A Protein-Only Rnase P in Human Mitochondria
[作者：Walker, SC; Engelke, DR,期刊：Cell, 页码：412-414 , 文章类型： Editorial Material，,卷期：2008年135-3]
- In bacteria, archaea, and the eukaryote nucleus, the endonuclease ribonuclease P (RNase P) is composed of a catalytic RNA that is assisted by protein subunits. Holzmann et al. (2008) now provide evidence that the human m...
- The Autistic Neuron: Troubled Translation?
[作者：Kelleher, RJ; Bear, MF,期刊：Cell, 页码：401-406 , 文章类型： Editorial Material，,卷期：2008年135-3]
- Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests that some molecular defects in autism may interfere with the ...
- It Takes a (Dysfunctional) Village to Raise a Tumor
[作者：Reilly, KM; Van Dyke, T,期刊：Cell, 页码：408-410 , 文章类型： Editorial Material，,卷期：2008年135-3]
- The tumor microenvironment is known to play an important role in tumorigenesis. In this issue, Yang et al. ( 2008) demonstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse ...
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