- Double Dissociation of the Effects of Haloperidol and the Dopamine D3 Receptor Antagonist ABT-127 on Acquisition vs. Expression of Cocaine-Conditioned Activity in Rats
[作者:Banasikowski, TJ; Bespalov, A; Drescher, K; Behl, B; Unger, L; Haupt, A; Schoemaker, H; Sullivan, JP; Gross, G; Beninger, RJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:506-515 , 文章类型: Article,,卷期:2010年335-2]
- Dopamine receptors play a critical role in reward-related learning, but receptor subtypes may be differentially involved. D2-preferring receptor antagonists, e. g., haloperidol, attenuate acquisition of cocaine-condition...
- Angiotensin II-Induced Migration of Vascular Smooth Muscle Cells Is Mediated by p38 Mitogen-Activated Protein Kinase-Activated c-Src through Spleen Tyrosine Kinase and Epidermal Growth Factor Receptor Transactivation (vol 332, pg 116, 2010)
[作者:Mugabe, BE; Yaghini, FA; Song, CY; Buharalioglu, CK; Waters, CM; Malik, KU,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:516-517 , 文章类型: Correction,,卷期:2010年335-2]
-
- Transmembrane Segment Five Serines of the D4 Dopamine Receptor Uniquely Influence the Interactions of Dopamine, Norepinephrine, and Ro10-4548 (vol 333, pg 682, 2010)
[作者:Cummings, DF; Ericksen, SS; Goetz, A; Schetz, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:518-518 , 文章类型: Correction,,卷期:2010年335-2]
-
- Obesity Up-Regulates Intermediate Conductance Calcium-Activated Potassium Channels and Myoendothelial Gap Junctions to Maintain Endothelial Vasodilator Function
[作者:Chadha, PS; Haddock, RE; Howitt, L; Morris, MJ; Murphy, TV; Grayson, TH; Sandow, SL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:284-293 , 文章类型: Article,,卷期:2010年335-2]
- The mechanisms involved in altered endothelial function in obesity-related cardiovascular disease are poorly understood. This study investigates the effect of chronic obesity on endothelium-dependent vasodilation and the...
- Role of Cannabinoid Receptor Type 1 Desensitization in Greater Tetrahydrocannabinol Impairment of Memory in Adolescent Rats
[作者:Moore, NLT; Greenleaf, ALR; Acheson, SK; Wilson, WA; Swartzwelder, HS; Kuhn, CM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:294-301 , 文章类型: Article,,卷期:2010年335-2]
- Adolescence is a well defined developmental period during which marijuana use is common. However, little is known about the response to marijuana in adolescents compared with adults. We have shown previously that adolesc...
- The Vascular Targeting Agent Combretastatin-A4 and a Novel cis-Restricted beta-Lactam Analogue, CA-432, Induce Apoptosis in Human Chronic Myeloid Leukemia Cells and Ex Vivo Patient Samples Including Those Displaying Multidrug Resistance
[作者:Greene, LM; Nathwani, SM; Bright, SA; Fayne, D; Croke, A; Gagliardi, M; McElligott, AM; O'Connor, L; Carr, M; Keely, NO; O'Boyle, NM; Carroll, P; Sarkadi, B; Conneally, E; Lloyd, DG; Lawler, M; Meegan, MJ; Zisterer, DM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:302-313 , 文章类型: Article,,卷期:2010年335-2]
- Combretastatin-A4 (CA-4) is a natural derivative of the African willow tree Combretum caffrum. CA-4 is one of the most potent antimitotic components of natural origin, but it is, however, intrinsically unstable. A novel ...
- Positron Emission Tomography Studies Using (15R)-16-m-[C-11]tolyl-17,18,19,20-tetranorisocarbacyclin Methyl Ester for the Evaluation of Hepatobiliary Transport
[作者:Takashima, T; Nagata, H; Nakae, T; Cui, Y; Wada, Y; Kitamura, S; Doi, H; Suzuki, M; Maeda, K; Kusuhara, H; Sugiyama, Y; Watanabe, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:314-323 , 文章类型: Article,,卷期:2010年335-2]
- A quantitative positron emission tomography (PET) methodology was developed for in vivo kinetic analysis of hepatobiliary transport. Serial abdominal PET scans were performed on normal and multidrug resistance-associated...
- Peroxisome Proliferator-Activated Receptor alpha Agonism Prevents Renal Damage and the Oxidative Stress and Inflammatory Processes Affecting the Brains of Stroke-Prone Rats
[作者:Gelosa, P; Banfi, C; Gianella, A; Brioschi, M; Pignieri, A; Nobili, E; Castiglioni, L; Cimino, M; Tremoli, E; Sironi, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:324-331 , 文章类型: Article,,卷期:2010年335-2]
- A growing body of evidence suggests that chronic kidney disease is a significant risk for cardiovascular events and stroke regardless of traditional risk factors. The aim of this study was to examine the effects of perox...
- Induction of Intestinal Multidrug Resistance-Associated Protein 2 by Glucagon-Like Peptide 2 in the Rat
[作者:Villanueva, SSM; Arias, A; Ruiz, ML; Rigalli, JP; Pellegrino, JM; Vore, M; Catania, VA; Mottino, AD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:332-341 , 文章类型: Article,,卷期:2010年335-2]
- The effects of glucagon-like peptide 2 (GLP-2) on expression and activity of jejunal multidrug resistance-associated protein 2 (Mrp2; Abcc2) and glutathione transferase (GST) were evaluated. After GLP-2 treatment (12 mu ...
- Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor
[作者:Liu, YX; Salvador, LA; Byeon, S; Ying, YC; Kwan, JC; Law, BK; Hong, JY; Luesch, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:351-361 , 文章类型: Article,,卷期:2010年335-2]
- Histone deacetylases (HDACs) are validated targets for anticancer therapy as attested by the approval of suberoylanilide hydroxamic acid (SAHA) and romidepsin (FK228) for treating cutaneous T cell lymphoma. We recently d...
- The Antiemetic 5-HT3 Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo
[作者:Rojas, C; Li, Y; Zhang, J; Stathis, M; Alt, J; Thomas, AG; Cantoreggi, S; Sebastiani, S; Pietra, C; Slusher, BS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:362-368 , 文章类型: Article,,卷期:2010年335-2]
- Palonosetron is the only 5-HT3 receptor antagonist approved for the treatment of delayed chemotherapy-induced nausea and vomiting (CINV) in moderately emetogenic chemotherapy. Accumulating evidence suggests that substanc...
- Disruption of the Gene for CYP1A2, which Is Expressed Primarily in Liver, Leads to Differential Regulation of Hepatic and Pulmonary Mouse CYP1A1 Expression and Augmented Human CYP1A1 Transcriptional Activation in Response to 3-Methylcholanthrene In Vivo
[作者:Jiang, WW; Wang, LH; Kondraganti, SR; Fazili, IS; Couroucli, XI; Felix, EA; Moorthy, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:369-379 , 文章类型: Article,,卷期:2010年335-2]
- The cytochrome P4501A (CYP1A) enzymes play important roles in the metabolic activation and detoxification of numerous environmental carcinogens, including polycyclic aromatic hydrocarbons (PAHs). In this study, we tested...
- Myeloperoxidase Expression as a Potential Determinant of Parthenolide-Induced Apoptosis in Leukemia Bulk and Leukemia Stem Cells
[作者:Kim, YR; Eom, JI; Kim, SJ; Jeung, HK; Cheong, JW; Kim, JS; Min, YH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:389-400 , 文章类型: Article,,卷期:2010年335-2]
- Given that parthenolide (PTL) is an effective antileukemic agent, identifying molecular markers that predict response to PTL is important. We evaluated the role of myeloperoxidase (MPO) in determining the sensitivity of ...
- The Anticonvulsive Drug Lamotrigine Blocks Neuronal alpha 4 beta 2 Nicotinic Acetylcholine Receptors
[作者:Zheng, C; Yang, KC; Liu, QA; Wang, MY; Shen, JX; Valles, AS; Lukas, RJ; Barrantes, FJ; Wu, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:401-408 , 文章类型: Article,,卷期:2010年335-2]
- Lamotrigine (LTG), an anticonvulsive drug, is often used for the treatment of a variety of epilepsies. In addition to block of sodium channels, LTG may act on other targets to exert its antiepileptic effect. In the prese...
|