- Differential In Vivo Effects on Target Pathways of a Novel Arylpyrazole Glucocorticoid Receptor Modulator Compared with Prednisolone
[作者:Roohk, DJ; Varady, KA; Turner, SM; Emson, CL; Gelling, RW; Shankaran, M; Lindwall, G; Shipp, LE; Scanlan, TS; Wang, JC; Hellerstein, MK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:281-289 , 文章类型: Article,,卷期:2010年333-1]
- Glucocorticoids are widely prescribed to treat autoimmune and inflammatory diseases. Although they are extremely potent, their utility in clinical practice is limited by a variety of adverse side effects. Development of ...
- Budesonide Prevents Cytokine-Induced Decrease of the Relaxant Responses to Formoterol and Terbutaline, but Not to Salmeterol, in Mouse Trachea
[作者:Adner, M; Larsson, B; Safholm, J; Naya, I; Miller-Larsson, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:273-280 , 文章类型: Article,,卷期:2010年333-1]
- During asthma exacerbations, increased airway inflammation may impair the effects of beta(2)-adrenoceptor (beta(2)AR) agonists. It is unclear whether this impairment is prevented by inhaled glucocorticoids (GCs). We have...
- The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis
[作者:Betts, AM; Clark, TH; Yang, JX; Treadway, JL; Li, M; Giovanelli, MA; Abdiche, Y; Stone, DM; Paralkar, VM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:2-13 , 文章类型: Article,,卷期:2010年333-1]
- PF-04840082 is a humanized prototype anti-Dickkopf-1 (Dkk-1) immunoglobulin isotype G(2) (IgG(2)) antibody for the treatment of osteoporosis. In vitro, PF-04840082 binds to human, monkey, rat, and mouse Dkk-1 with high a...
- A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells
[作者:Sane, KM; Mynderse, M; LaLonde, DT; Dean, IS; Wojtkowiak, JW; Fouad, F; Borch, RF; Reiners, JJ; Gibbs, RA; Mattingly, RR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:23-33 , 文章类型: Article,,卷期:2010年333-1]
- Prenylation inhibitors have gained increasing attention as potential therapeutics for cancer. Initial work focused on inhibitors of farnesylation, but more recently geranylgeranyl transferase inhibitors (GGTIs) have begu...
- Anesthetic-Induced Neurodegeneration Mediated via Inositol 1,4,5-Trisphosphate Receptors
[作者:Zhao, YF; Liang, G; Chen, QR; Joseph, DJ; Meng, QC; Eckenhoff, RG; Eckenhoff, MF; Wei, HF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:14-22 , 文章类型: Article,,卷期:2010年333-1]
- The commonly used general anesthetic isoflurane induces widespread neurodegeneration in the developing mammalian brain through poorly understood mechanisms. We have investigated whether excessive Ca2+ release from the en...
- Mitogen-Activated Protein Kinase Phosphatase-1 Negatively Regulates the Expression of Interleukin-6, Interleukin-8, and Cyclooxygenase-2 in A549 Human Lung Epithelial Cells
[作者:Turpeinen, T; Nieminen, R; Moilanen, E; Korhonen, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:310-318 , 文章类型: Article,,卷期:2010年333-1]
- Mitogen-activated protein kinase phosphatase (MKP)-1 is a protein phosphatase that regulates the activity of p38 mitogen-activated protein (MAP) kinase and c-Jun NH2-terminal kinase (JNK) and, to lesser extent, p42/44 ex...
- A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice
[作者:Shioda, N; Yamamoto, Y; Han, F; Moriguchi, S; Yamaguchi, Y; Hino, M; Fukunaga, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:43-50 , 文章类型: Article,,卷期:2010年333-1]
- In the adult brain, neurogenesis persistently occurs in the sub-granular zone of the hippocampal dentate gyrus (DG), and impaired neurogenesis is implicated in depressive behaviors and poor learning memory. Here, we inve...
- Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine
[作者:Ito, S; Kusuhara, H; Kuroiwa, Y; Wu, CY; Moriyama, Y; Inoue, K; Kondo, T; Yuasa, H; Nakayama, H; Horita, S; Sugiyama, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:341-350 , 文章类型: Article,,卷期:2010年333-1]
- This report describes a potent and selective inhibitor of multidrug and toxin extrusion (MATE) protein, pyrimethamine (PYR), and examines its effect on the urinary and biliary excretion of typical Mate1 substrates in mic...
- Modulation of alpha(2)-Adrenoceptor Functions by Heterotrimeric G alpha(i) Protein Isoforms (vol 331, pg 35, 2009)
[作者:Albarran-Juarez, J; Gilsbach, R; Piekorz, R; Pexa, K; Beetz, N; Schneider, J; Nuernberg, B; Birnbaumer, L; Hein, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:351-351 , 文章类型: Correction,,卷期:2010年333-1]
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- Cariprazine (RGH-188), a Dopamine D-3 Receptor-Preferring, D-3/D-2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
[作者:Kiss, B; Horvath, A; Nemethy, Z; Schmidt, E; Laszlovszky, I; Bugovics, G; Fazekas, K; Hornok, K; Orosz, S; Gyertyan, I; Agai-Csongor, E; Domany, G; Tihanyi, K; Adham, N; Szombathelyi, Z,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:328-340 , 文章类型: Article,,卷期:2010年333-1]
- Cariprazine {RGH-188; trans-N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-N',N'-dimethylurea hydrochloride}, a novel candidate antipsychotic, demonstrated approximately 10-fold higher affinity for human...
- Cystic Fibrosis Transmembrane Regulator Inhibitors CFTRinh-172 and GlyH-101 Target Mitochondrial Functions, Independently of Chloride Channel Inhibition
[作者:Kelly, M; Trudel, S; Brouillard, F; Bouillaud, F; Colas, J; Nguyen-Khoa, T; Ollero, M; Edelman, A; Fritsch, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:60-69 , 文章类型: Article,,卷期:2010年333-1]
- Two highly potent and selective cystic fibrosis (CF) transmembrane regulator (CFTR) inhibitors have been identified by high-throughput screening: the thiazolidinone CFTRinh-172 [3-[(3-trifluoromethyl)phenyl]-5-[(4-carbox...
- Molecular Basis for Agonism in the BB3 Receptor: An Epitope Located on the Interface of Transmembrane-III, -VI, and -VII
[作者:Gbahou, F; Holst, B; Schwartz, TW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:51-59 , 文章类型: Article,,卷期:2010年333-1]
- Epitopes determining the agonist property of two structurally distinct selective ligands for the human bombesin receptor subtype 3 (BB3), [D-Tyr6,(R)-Apa11, Phe13, Nle14]-bombesin(6-14) (Pep-1) and Ac-Phe-Trp-Ala-His(Tau...
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