- Cyclin-Dependent Kinase Inhibits Reinitiation of a Normal S-Phase Program during G(2) in Fission Yeast
[作者:Kiang, L; Heichinger, C; Watt, S; Bahler, J; Nurse, P,期刊:Molecular and Cellular Biology, 页码:4025-4032 , 文章类型: Article,,卷期:2009年29-15]
- To achieve faithful replication of the genome once in each cell cycle, reinitiation of S phase is prevented in G(2) and origins are restricted from refiring within S phase. We have investigated the block to rereplication...
- Three Proteins of the U7-Specific Sm Ring Function as the Molecular Ruler To Determine the Site of 3 '-End Processing in Mammalian Histone Pre-mRNA
[作者:Yang, XC; Torres, MP; Marzluff, WF; Dominski, Z,期刊:Molecular and Cellular Biology, 页码:4045-4056 , 文章类型: Article,,卷期:2009年29-15]
- Cleavage of histone pre-mRNAs at the 3' end is guided by the U7 snRNP, which is a component of a larger 3'-end processing complex. To identify other components of this complex, we isolated proteins that stably associate ...
- High-Affinity Transporters for NAD(+) Precursors in Candida glabrata Are Regulated by Hst1 and Induced in Response to Niacin Limitation
[作者:Ma, B; Pan, SJ; Domergue, R; Rigby, T; Whiteway, M; Johnson, D; Cormack, BP,期刊:Molecular and Cellular Biology, 页码:4067-4079 , 文章类型: Article,,卷期:2009年29-15]
- The yeast Candida glabrata is an opportunistic pathogen of humans. C. glabrata is a NAD(+) auxotroph, and its growth depends on the availability of niacin (environmental vitamin precursors of NAD(+)). We have previously ...
- Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1 alpha Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
[作者:Sudarshan, S; Sourbier, C; Kong, HS; Block, K; Romero, VAV; Yang, YF; Galindo, C; Mollapour, M; Scroggins, B; Goode, N; Lee, MJ; Gourlay, CW; Trepel, J; Linehan, WM; Neckers, L,期刊:Molecular and Cellular Biology, 页码:4080-4090 , 文章类型: Article,,卷期:2009年29-15]
- Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an inherited cancer syndrome linked to biallelic inactivation of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH). Individuals with ...
- Differentiation-Dependent Interactions between RUNX-1 and FLI-1 during Megakaryocyte Development
[作者:Huang, H; Yu, M; Akie, TE; Moran, TB; Woo, AJ; Tu, N; Waldon, Z; Lin, YY; Steen, H; Cantor, AB,期刊:Molecular and Cellular Biology, 页码:4103-4115 , 文章类型: Article,,卷期:2009年29-15]
- The transcription factor RUNX-1 plays a key role in megakaryocyte differentiation and is mutated in cases of myelodysplastic syndrome and leukemia. In this study, we purified RUNX-1-containing multiprotein complexes from...
- SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1
[作者:Rajamohan, SB; Pillai, VB; Gupta, M; Sundaresan, NR; Birukov, KG; Samant, S; Hottiger, MO; Gupta, MP,期刊:Molecular and Cellular Biology, 页码:4116-4129 , 文章类型: Article,,卷期:2009年29-15]
- Poly(ADP-ribose) polymerase 1 (PARP1) and SIRT1 deacetylase are two NAD-dependent enzymes which play major roles in the decision of a cell to live or to die in a stress situation. Because of the dependence of both enzyme...
- Cdo Binds Abl To Promote p38 alpha/beta Mitogen-Activated Protein Kinase Activity and Myogenic Differentiation
[作者:Bae, GU; Kim, BG; Lee, HJ; Oh, JE; Lee, SJ; Zhang, W; Krauss, RS; Kang, JS,期刊:Molecular and Cellular Biology, 页码:4130-4143 , 文章类型: Article,,卷期:2009年29-15]
- The p38 mitogen-activated protein kinase (MAPK) pathway is required for differentiation of skeletal myoblasts, but how the pathway is activated during this process is not well understood. One mechanism involves the cell ...
- Serine 58 of 14-3-3 zeta Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death
[作者:Zhou, JB; Shao, ZL; Kerkela, R; Ichijo, H; Muslin, AJ; Pombo, C; Force, T,期刊:Molecular and Cellular Biology, 页码:4167-4176 , 文章类型: Article,,卷期:2009年29-15]
- Oxidant stress is a ubiquitous stressor with negative impacts on multiple cell types. ASK1 is a central mediator of oxidant injury, but while mechanisms of its inhibition, such as sequestration by 14-3-3 proteins and thi...
- Serine Protease HtrA1 Associates with Microtubules and Inhibits Cell Migration
[作者:Chien, J; Ota, T; Aletti, G; Shridhar, R; Boccellino, M; Quagliuolo, L; Baldi, A; Shridhar, V,期刊:Molecular and Cellular Biology, 页码:4177-4187 , 文章类型: Article,,卷期:2009年29-15]
- HtrA1 belongs to a family of serine proteases found in organisms ranging from bacteria to humans. Bacterial HtrA1 (DegP) is a heat shock-induced protein that behaves as a chaperone at low temperature and as a protease at...
- Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation
[作者:Bockstaele, L; Bisteau, X; Paternot, S; Roger, PP,期刊:Molecular and Cellular Biology, 页码:4188-4200 , 文章类型: Article,,卷期:2009年29-15]
- The homologous cyclin-dependent kinases (CDK) CDK4 and CDK6 integrate mitogenic and oncogenic signaling cascades with the cell cycle. Their activation requires binding to a D-type cyclin and then T-loop phosphorylation a...
- ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor
[作者:Bai, XH; Wang, DW; Kong, L; Zhang, Y; Luan, Y; Kobayashi, T; Kronenberg, HM; Yu, XP; Liu, CJ,期刊:Molecular and Cellular Biology, 页码:4201-4219 , 文章类型: Article,,卷期:2009年29-15]
- ADAMTS-7, a metalloproteinase that belongs to ADAMTS family, is important for the degradation of cartilage extracellular matrix proteins in arthritis. Herein we report that ADAMTS-7 is upregulated during chondrocyte diff...
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