- Structural Basis for the Interaction Between Carbonic Anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides
[作者:MADER PAVEL; BRYNDA JIRI; GITTO ROSARIA; AGNELLO STEFANO; PACHL PETR; SUPURAN CLAUDIU T; CHIMIRRI ALBA; REZACOVA PAVLINA,期刊:Journal of Medicinal Chemistry, 页码:2522-2526 , 文章类型: Article,,卷期:2011年54-7]
- lsoquinolinesulfonamides inhibit human carbonic anhydrases (hCAs) and display selectivity toward therapeutically relevant isozymes. The crystal structure of hCA 11 in complex with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydr...
- Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4-Acetylpiperazin-1-y1)-5-(3-nitrobenzylamino)-7-(trifluoromethyl)qui noline as a Novel Anticancer Agent
[作者:WANG YUANXIANG; AI JING; WANG YING; CHEN YI; WANG LU; LIU GANG; GENG MEIYU; ZHANG AO,期刊:Journal of Medicinal Chemistry, 页码:2127-2142 , 文章类型: Article,,卷期:2011年54-7]
- By use of an improved synthetic strategy, a series of 3,5-disubstituted and 3,5,7-trisubstituted quinolines were readily prepared. 3,5,7-Trisubstituted quinolines 21a-c, 211, and 27a-c were identified as the most potent ...
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