- The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb-1 by heat processing
[作者:Lee, YJ; Kim, HY; Kang, KS; Lee, JG; Yokozawa, T; Park, JH,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4515-4520 , 文章类型: Article,,卷期:2008年18-16]
- The chemical and hydroxyl radical (.OH) scavenging activity changes of ginsenoside Rb-1 (Rb-1) by heat processing were investigated in this study. Rb-1 was changed into 20(S)-Rg(3), 20(R)-Rg3, Rk(1), and Rg(5) by heat pr...
- Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds
[作者:Fernandes, L; Fischer, FL; Ribeiro, CW; Silveira, GP; Sa, MM; Nome, F; Terenzi, H,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4499-4502 , 文章类型: Article,,卷期:2008年18-16]
- Hydrolysis of DNA is of increasing importance in biotechnology and medicine. In this Letter, we present the DNA-cleavage potential of metal-free hydroxylamines and oximes as new members of nucleic acid cleavage agents. (...
- Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties
[作者:Regan, CF; Guo, ZQ; Chen, YS; Huang, CQ; Chen, M; Jiang, WL; Rueter, JK; Coon, T; Chen, C; Saunders, J; Brown, MS; Betz, SF; Struthers, RS; Yang, C; Wen, J; Madan, A; Zhu, YF,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4503-4507 , 文章类型: Article,,卷期:2008年18-16]
- A novel series of potent zwitterionic uracil GnRH antagonists were discovered that showed reduced liability for CYP3A4 enzyme inhibition. (c) 2008 Elsevier Ltd. All rights reserved.
- Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
[作者:Zeng, LF; Zhang, HS; Wang, YH; Sanchez, T; Zheng, YT; Neamati, N; Long, YQ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4521-4524 , 文章类型: Article,,卷期:2008年18-16]
- Three new types of aryl diketo acid (ADK) isosteres were designed by conversion of the biologically labile 1,3-diketo unit into heteroaromatic motif such as isoxazole, isothiazole, or 1H-pyrazole to improve the physicoch...
- Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: Effect of introduction of fluorine at the linker part
[作者:Kasuga, J; Oyama, T; Hirakawa, Y; Makishima, M; Morikawa, K; Hashimoto, Y; Miyachi, H,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4525-4528 , 文章类型: Article,,卷期:2008年18-16]
- We developed a potent peroxisome proliferator-activated receptor pan agonist (a candidate drug for treatment of altered metabolic homeostasis) by introducing fluorine atoms at appropriate position(s) of the known phenylp...
- Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A(4) hydrolase inhibitors
[作者:Enomoto, H; Morikawa, Y; Miyake, Y; Tsuji, F; Mizuchi, M; Suhara, H; Fujimura, K; Horiuchi, M; Ban, M,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4529-4532 , 文章类型: Article,,卷期:2008年18-16]
- We studied the synthetic modification of structurally similar N-mercaptoacyl-L-proline and (4R)-N-mercaptoacylthiazolidine-4-carboxylic acid to obtain potent leukotriene A(4) (LTA(4)) hydrolase inhibitors. An N-mercaptoa...
- Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination
[作者:Shiraishi, T; Kadono, S; Haramura, M; Kodama, H; Ono, Y; Iikura, H; Esaki, T; Koga, T; Hattori, K; Watanabe, Y; Sakamoto, A; Yoshihashi, K; Kitazawa, T; Esaki, K; Ohta, M; Sato, H; Kozono, T,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4533-4537 , 文章类型: Article,,卷期:2008年18-16]
- Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. Compound 1 was discovered from focused screening of serine protease-directed com...
- A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9 ',2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-inflammatory agents
[作者:Hafez, HN; Hegab, MI; Ahmed-Farag, IS; El-Gazzar, ABA,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4538-4543 , 文章类型: Article,,卷期:2008年18-16]
- The 1,3-dipolar cycloaddition of nitrile immes to 9H-thioxanthone-9-thione and 9H-xanthone-9-thione afforded novel spiro-thioxanthene-9',2-[1,3,4] thiadiazoles 6a-g and spiro-xanthene-9',2-[1,3,4]thiadiazoles 7a-g in goo...
- Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition
[作者:Lee, SW; Kim, YK; Kim, K; Lee, HS; Choi, JH; Lee, WS; Jun, CD; Park, JH; Lee, JM; Rho, MC,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4544-4546 , 文章类型: Article,,卷期:2008年18-16]
- Eight alkamides 1-8 were isolated by bioassay-guided isolation of EtOH extracts of the fruits of Piper longum and Piper nigum (Piperaceae). Their structures were elucidated by spectroscopic analysis (H-1, C-13 NMR, and E...
- Fluorescence generation from tandem repeats of a malachite green RNA aptamer using rolling circle transcription
[作者:Furukawa, K; Abe, H; Abe, N; Harada, M; Tsuneda, S; Ito, Y,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4562-4565 , 文章类型: Article,,卷期:2008年18-16]
- We demonstrate a generation of tandem repeats of a malachite green (MG) RNA aptamer using rolling circle transcription. To keep the higher-order structure of each aptamer on long RNA, we designed a sequence of circular D...
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