- Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles
[作者:Ohya, Y; Takeda, S; Shibata, Y; Ouchi, T; Kano, A; Iwata, T; Mochizuki, S; Taniwaki, Y; Maruyama, A,期刊:Journal of controlled release, 页码:104-110 , 文章类型: Article,,卷期:2011年155-1]
- Polymeric micelles, as drug delivery vehicles, must achieve specific targeting and high stability in the body for efficient drug delivery. We recently reported the preparation of polyanion-coated biodegradable polymeric ...
- pH-responsive polymeric micelle based on PEG-poly(beta-amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area
[作者:Gao, GH; Lee, JW; Nguyen, MK; Im, GH; Yang, J; Heo, H; Jeon, P; Park, TG; Lee, JH; Lee, DS,期刊:Journal of controlled release, 页码:11-17 , 文章类型: Article,,卷期:2011年155-1]
- A series of pH-responsive polymeric micelles is developed to act as intelligent carriers to deliver iron oxide (Fe(3)O(4)) nanoparticles and respond rapidly to an acidic stimuli environment for magnetic resonance imaging...
- RVG peptide tethered bioreducible polyethylenimine for gene delivery to brain
[作者:Son, S; Hwang, DW; Singha, K; Jeong, JH; Park, TG; Lee, DS; Kim, WJ,期刊:Journal of controlled release, 页码:18-25 , 文章类型: Article,,卷期:2011年155-1]
- The work demonstrated the successful delivery of gene to mouse brain overcoming the blood-brain barrier (BBB) through expedient vector construct having RVG peptide as targeting ligand for neuronal cells. The newly develo...
- Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei
[作者:Wang, HY; Chen, JX; Sun, YX; Deng, JZ; Li, C; Zhang, XZ; Zhuo, RX,期刊:Journal of controlled release, 页码:26-33 , 文章类型: Article,,卷期:2011年155-1]
- Cellular uptake and nuclear localization are two barriers to gene delivery. Here, we designed new gene delivery carriers with an N-terminal stearylated (SIR) nuclear localization signal (NLS). PKKKRKV, present in the Sim...
- Controlled synthesis of PEI-coated gold nanoparticles using reductive catechol chemistry for siRNA delivery
[作者:Lee, Y; Lee, SH; Kim, JS; Maruyama, A; Chen, XS; Park, TG,期刊:Journal of controlled release, 页码:3-10 , 文章类型: Article,,卷期:2011年155-1]
- Development of nano-sized gene delivery vehicles for small interfering RNA (siRNA) delivery is of great importance for their clinical applications such as cancer therapy. Herein, we demonstrate the controlled synthesis o...
- Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates
[作者:Ishihara, T; Kano, A; Obara, K; Saito, M; Chen, X; Park, TG; Akaike, T; Maruyama, A,期刊:Journal of controlled release, 页码:34-39 , 文章类型: Article,,卷期:2011年155-1]
- In order for peptide nucleic acids (PNAs) to be effective as therapeutic agents, methods for cellular delivery must be developed. Here we demonstrate spontaneous nuclear localization and antisense effects of peptide nucl...
- Transgene regulation system responding to Rho associated coiled-coil kinase (ROCK) activation
[作者:Tsuchiya, A; Kang, JH; Asai, D; Mori, T; Niidome, T; Katayama, Y,期刊:Journal of controlled release, 页码:40-46 , 文章类型: Article,,卷期:2011年155-1]
- Recently, we have proposed a new system of gene regulation called 'drug or gene delivery system responding to cellular signals' (D-RECS). In this system, transgene expression is activated in response to intracellular tar...
- RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers
[作者:Tian, HY; Lin, L; Chen, J; Chen, XS; Park, TG; Maruyama, A,期刊:Journal of controlled release, 页码:47-53 , 文章类型: Article,,卷期:2011年155-1]
- Hyaluronic acid (HA), a natural anionic mucopolysaccharide, was used to coat polyethylenimine-poly(gamma-benzyl L-glutamate)/DNA (PEI-PBLG/DNA) complexes. HA was further modified by introducing RGD peptide with grafting ...
- Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug
[作者:Shim, G; Han, SE; Yu, YH; Lee, S; Lee, HY; Kim, K; Kwon, IC; Park, TG; Kim, YB; Choi, YS; Kim, CW; Oh, YK,期刊:Journal of controlled release, 页码:60-66 , 文章类型: Article,,卷期:2011年155-1]
- Oligolysine-based cationic lipid derivatives were synthesized for delivery of siRNA, and formulated into cationic liposomes. Among various oligolysine-based lipid derivatives differing in lysine residue number and lipid ...
- Revisit complexation between DNA and polyethylenimine - Effect of uncomplexed chains free in the solution mixture on gene transfection
[作者:Yue, YA; Jin, F; Deng, R; Cai, JG; Chen, YC; Lin, MCM; Kung, HF; Wu, C,期刊:Journal of controlled release, 页码:67-76 , 文章类型: Article,,卷期:2011年155-1]
- Our revisit of the complexation between anionic DNA and cationic polyethylenimine (PEI) in both water and phosphate buffered saline (PBS) by using a combination of laser light scattering (LLS) and gel electrophoresis con...
- Peptide dendrimers as efficient and biocompatible gene delivery vectors: Synthesis and in vitro characterization
[作者:Luo, K; Li, CX; Wang, G; Nie, Y; He, B; Wu, Y; Gu, ZW,期刊:Journal of controlled release, 页码:77-87 , 文章类型: Article,,卷期:2011年155-1]
- We report the synthesis and characterization of different generations of dendritic poly(L-lysine) vectors, and their use for in vivo gene transfection. Gel retardation assay revealed that the dendrimers could form comple...
- A duplex oligodeoxynucleotide-dendrimer bioconjugate as a novel delivery vehicle for doxorubicin in in vivo cancer therapy
[作者:Lee, IH; Yu, MK; Kim, IH; Lee, JH; Park, TG; Jon, S,期刊:Journal of controlled release, 页码:88-95 , 文章类型: Article,,卷期:2011年155-1]
- We designed a bioconjugate between duplex oligodeoxynucleotides (dODNs) and a dendrimer (DEN) and demonstrate its feasibility as a novel delivery system for doxorubicin (Dox) in animal tumor models and against cancer cel...
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