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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共42条记录   Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice [作者：Gardenghi, S; Ramos, P; Marongiu, MF; Melchiori, L; Breda, L; Guy, E; Muirhead, K; Rao, N; Roy, CN; Andrews, NC; Nemeth, E; Follenzi, A; An, XL; Mohandas, N; Ginzburg, Y; Rachmilewitz, EA; Giardina, PJ; Grady, RW; Rivella, S,期刊：Journal of clinical investigation, 页码：4466-4477 , 文章类型： Article，,卷期：2010年120-12] Excessive iron absorption is one of the main features of beta-thalassemia and can lead to severe morbidity and mortality Serial analyses of beta-thalassemic mice indicate that while hemoglobin levels decrease over time, ... The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression [作者：Sharma, A; Yeow, WS; Ertel, A; Coleman, I; Clegg, N; Thangavel, C; Morrissey, C; Zhang, XT; Comstock, CES; Witkiewicz, AK; Gomella, L; Knudsen, ES; Nelson, PS; Knudsen, KE,期刊：Journal of clinical investigation, 页码：4478-4492 , 文章类型： Article，,卷期：2010年120-12] Retanoblastoma (RB, encoded by RB1) is a tumor suppressor that is frequently disrupted m tumorigenesis and acts m multiple cell types to suppress cell cycle progression The role of RB in tumor progression, however, is po... Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice [作者：Jung, CR; Lim, JH; Choi, Y; Kim, DG; Kang, KJ; Noh, SM; Im, DS,期刊：Journal of clinical investigation, 页码：4493-4506 , 文章类型： Article，,卷期：2010年120-12] The human E3 ubiquitin ligase murine double minute 2 (MDM2) targets the tumor suppressor p53 for ubiquitination and degradation but also promotes its own ubiquitination and subsequent degradation As the balance between M... Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors [作者：Harandi, OF; Hedge, S; Wu, DC; Mckeone, D; Paulson, RF,期刊：Journal of clinical investigation, 页码：4507-4519 , 文章类型： Article，,卷期：2010年120-12] Acute anemic stress induces a systemic response designed to increase oxygen delivery to hypoxic tissues Increased erythropoiesis is a key component of this response Recovery from acute anemia relies on stress erythropoie... Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties [作者：Slavuljica, I; Busche, A; Babic, M; Mitrovic, M; Gasparovic, I; Cekinovic, D; Car, EM; Pugel, EP; Cikovic, A; Lisnic, VJ; Britt, WJ; Koszinowski, U; Messerle, M; Krmpotic, A; Jonjic, S,期刊：Journal of clinical investigation, 页码：4532-4545 , 文章类型： Article，,卷期：2010年120-12] Human CMV (HCMV) is a major cause of morbidity and mortality in both congenitally infected and immunocompromised individuals Development of an effective HCMV vaccine would help protect these vulnerable groups NK group 2,... Tim-3 expression on PD-1(+) HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity [作者：McMahan, RH; Golden-Mason, L; Nishimura, MI; McMahon, BJ; Kemper, M; Allen, TM; Gretch, DR; Rosen, HR,期刊：Journal of clinical investigation, 页码：4546-4557 , 文章类型： Article，,卷期：2010年120-12] Having successfully developed mechanisms to evade immune clearance, hepatitis C virus (HCV) establishes persistent infection in approximately 75%-80% of patients In these individuals, the function of HCV-specific CD8(+) ... Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs [作者：Grinberg-Bleyer, Y; Saadoun, D; Baeyens, A; Billiard, F; Goldstein, JD; Gregoire, S; Martin, GH; Elhage, R; Derian, N; Carpentier, W; Marodon, G; Klatzmann, D; Piaggio, E; Salomon, BL,期刊：Journal of clinical investigation, 页码：4558-4568 , 文章类型： Article，,卷期：2010年120-12] CD4(+)CD25(+)Foxp3(+) Tregs play a major role in prevention of autoimmune diseases The suppressive effect of Tregs on effector T cells (Teffs), the cells that can mediate autoimmunity, has been extensively studied Howeve... BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy [作者：Cerchietti, LC; Hatzi, K; Caldas-Lopes, E; Yang, SN; Figueroa, ME; Morin, RD; Hirst, M; Mendez, L; Shaknovich, R; Cole, PA; Bhalla, K; Gascoyne, RD; Marra, M; Chiosis, G; Melnick, A,期刊：Journal of clinical investigation, 页码：4569-4582 , 文章类型： Article，,卷期：2010年120-12] B cell lymphoma 6 (BCL6), which encodes a transcriptional repressor, is a critical oncogene in diffuse large B cell lymphomas (DLBCLs) Although a retro-inverted BCL6 peptide inhibitor (RI-BPI) was recently shown to poten... PPAR gamma-induced cardiolipotoxicity in mice is ameliorated by PPAR alpha deficiency despite increases in fatty acid oxidation (vol 120, pg 3443, 2010) [作者：Son, NH; Yu, SQ; Tuinei, J; Arai, K; Hamai, H; Homma, S; Shulman, GI; Abel, ED; Goldberg, IJ,期刊：Journal of clinical investigation, 页码：4583-4583 , 文章类型： Correction，,卷期：2010年120-12] Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice (vol 120, pg 4091, 2010) [作者：Chen, C; Liu, Y; Liu, Y; Zheng, P,期刊：Journal of clinical investigation, 页码：4583-4583 , 文章类型： Correction，,卷期：2010年120-12] Thrivin' (not just survivin') in Philadelphia [作者：Claiborn, K,期刊：Journal of clinical investigation, 页码：4166-4166 , 文章类型： News Item，,卷期：2010年120-12] Advances and challenges in malaria vaccine development [作者：Crompton, PD; Pierce, SK; Miller, LH,期刊：Journal of clinical investigation, 页码：4168-4178 , 文章类型： Article，,卷期：2010年120-12] Malaria caused by Plasmodium falciparum remains a major public health threat, especially among children and pregnant women in Africa An effective malaria vaccine would be a valuable tool to reduce the disease burden a... The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? [作者：Macleod, KF,期刊：Journal of clinical investigation, 页码：4179-4182 , 文章类型： Editorial Material，,卷期：2010年120-12] The retinoblastoma tumor suppressor gene (RB1, encoding RB) is often cited as a gatekeeper, whose inactivation - direct or indirect - is a rate-limiting step for tumor initiation However, in this issue of the JCI, Sharma... Which species are in your feces? [作者：Zaph, C,期刊：Journal of clinical investigation, 页码：4182-4185 , 文章类型： Editorial Material，,卷期：2010年120-12] Nosocomial infections (ie, infections acquired as a result of treatment in a hospital or health care unit) result in approximately 100,000 deaths and cost more than 25 billion dollars per year in the US alone These infec... Integral role of integrins in Th17 development [作者：Pociask, DA; Kolls, JK,期刊：Journal of clinical investigation, 页码：4185-4187 , 文章类型： Editorial Material，,卷期：2010年120-12] A lineage of CD4(+) T cells known as Th17 cells, which are derived by exposure of naive CD4(+) T cells to IL-6 and TGF-beta, have been implicated in several autoimmune diseases In this issue of the JCI, studies by Achary... A tincture of hepcidin cures all: the potential for hepcidin therapeutics [作者：Bartnikas, TB; Fleming, MD,期刊：Journal of clinical investigation, 页码：4187-4190 , 文章类型： Editorial Material，,卷期：2010年120-12] Iron overload as a result of blood transfusions and excessive intestinal iron absorption can be a complication of chronic anemias such as beta-thalassemia. Inappropriately low levels of hepcidin, a negative regulator of ...