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[摘要]：The retinoblastoma tumor suppressor gene (RB1, encoding RB) is often cited as a gatekeeper, whose inactivation - direct or indirect - is a rate-limiting step for tumor initiation However, in this issue of the JCI, Sharma et al show that RB1 loss is a late event m human prostate cancer that is coincident with the emergence of castrate-resistant metastatic disease This role for RB1 was linked to both E2F transcription factor 1-driven upregulation of the androgen receptor (AR) and increased recruitment of the AR to target gene promoters This unexpected function for RB1 in late-stage cancer calls upon us to reassess the significance of RB1 inactivation in other cancers in terms of its timing, function in disease etiology, and relevance for cancer therapy |
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