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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Fine-Tuning Multiprotein Complexes Using Small Molecules [作者：THOMPSON ANDREA D; DUGAN AMANDA; GESTWICKI JASON E; MAPP ANNA K,期刊：ACS CHEMICAL BIOLOGY, 页码：1311-1320 , 文章类型： Review，,卷期：2012年7-8] Multiprotein complexes such as the transcriptional machinery, signaling hubs, and protein folding machines are typically composed of at least one enzyme combined with multiple non-enzymes. Often the components of these c... Targeted Metabolomics Reveals a Male Pheromone and Sex-Specific Ascaroside Biosynthesis in Caenorhabditis elegans [作者：IZRAYELIT YEVGENIY; SRINIVASAN JAGAN; CAMPBELL SYDNEY L; JO YEARA; VON REUSS STEPHAN H; GENOFF MARGAUX C; STERNBERG PAUL W; SCHROEDER FRANK C,期刊：ACS CHEMICAL BIOLOGY, 页码：1321-1325 , 文章类型： Article，,卷期：2012年7-8] In the model organism Caenorhabditis elegans, a class of small molecule signals called ascarosides regulate development, mating, and social behaviors. Ascaroside production has been studied in the predominant sex, the he... State-selective Metabolic Labeling of Cellular Proteins [作者：NGO JOHN T; BABIN BRETT M; CHAMPION JULIE A; SCHUMAN ERIN M; TIRRELL DAVID A,期刊：ACS CHEMICAL BIOLOGY, 页码：1326-1330 , 文章类型： Article，,卷期：2012年7-8] Transcriptional activity from a specified promoter can provide a useful marker for the physiological state of a cell. Here we introduce a method for selective tagging of proteins made in cells in which specified promoter... Discovery of a Nitric Oxide Responsive Quorum Sensing Circuit in Vibrio harveyi [作者：HENARES BERNADETTE M; HIGGINS KATE E; BOON ELIZABETH M,期刊：ACS CHEMICAL BIOLOGY, 页码：1331-1336 , 文章类型： Article，,卷期：2012年7-8] Bacteria use small molecules to assess the density and identity of nearby organisms and formulate a response. This Drocess, called quorum sensing (QS), commonly regulates bioluminescence, biofilm formation, and virulence... Release Factor One Is Nonessential in Escherichia coli [作者：JOHNSON DAVID B F; WANG CHONG; XU JIANFENG; SCHULTZ MATTHEW D; SCHMITZ ROBERT J; ECKER JOSEPH R; WANG LEI,期刊：ACS CHEMICAL BIOLOGY, 页码：1337-1344 , 文章类型： Article，,卷期：2012年7-8] Recoding a stop codon to an amino acid may afford orthogonal genetic systems for biosynthesizing new protein and organism properties. Although reassignment of stop codons has been found in extant organisms, a model organ... Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and Characterization [作者：POMERANTZ WILLIAM C; WANG NINGKUN; LIPINSKI ASHLEY K; WANG RURUN; CIERPICKI TOMASZ; MAPP ANNA K,期刊：ACS CHEMICAL BIOLOGY, 页码：1345-1350 , 文章类型： Article，,卷期：2012年7-8] The conformationally dynamic binding surfaces of transcription complexes present a particular challenge for ligand discovery and characterization. In the case of the KIX domain of the master coactivator CBP/p300, few sma... Visualizing the 16-Membered Ring Macrolides Tildipirosin and Tilmicosin Bound to Their Ribosomal Site [作者：POEHLSGAARD JACOB; ANDERSEN NIELS M; WARRASS RALF; DOUTHWAITE STEPHEN,期刊：ACS CHEMICAL BIOLOGY, 页码：1351-1355 , 文章类型： Article，,卷期：2012年7-8] The veterinary antibiotic tildipirosin (20,23-dipiperidinyl-mycaminosyl-tylonolide, Zuprevo) was developed recently to treat bovine and swine respiratory tract infections caused by bacterial pathogens such as Pasteurella... Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-Specific Intracellular Inhibitors of c-Jun N-Terminal Kinases [作者：PARIZEK PETRA; KUMMER LUTZ; RUBE PETER; PRINZ ANKE; HERBERG FRIEDRICH W; PLUECKTHUN ANDREAS,期刊：ACS CHEMICAL BIOLOGY, 页码：1356-1366 , 文章类型： Article，,卷期：2012年7-8] The c-Jun N-terminal kinases (JNKs) are involved in many biological processes such as proliferation, differentiation, apoptosis, and inflammation and occur in highly similar isoforms in eukaryotic cells. Isoform-specific... Bipartite Tetracysteine Display Reveals Allosteric Control of Ligand-Specific EGFR Activation [作者：SCHECK REBECCA A; LOWDER MELISSA A; APPELBAUM JACOB S; SCHEPARTZ ALANNA,期刊：ACS CHEMICAL BIOLOGY, 页码：1367-1376 , 文章类型： Article，,卷期：2012年7-8] Aberrant activation of the epidermal growth factor receptor (EGFR), a prototypic receptor tyrosine kinase, is critical to the biology of many common cancers. The molecular events that define how EGFR transmits an extrace... Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening [作者：STANLEY SARAH A; GRANT SARAH SCHMIDT; KAWATE TOMOHIKO; IWASE NORIAKI; SHIMIZU MOTOHISA; WIVAGG CARL; SILVIS MELANIE; KAZYANSKAYA EDWARD; AQUADRO JOHN; GOLAS AARON; FITZGERALD MICHAEL; DAI HUANQIN; ZHANG LIXIN; HUNG DEBORAH T,期刊：ACS CHEMICAL BIOLOGY, 页码：1377-1384 , 文章类型： Article，,卷期：2012年7-8] Despite the urgent need for new antitubercular drugs, few are on the horizon. To combat the problem of emerging drug resistance, structurally unique chemical entities that inhibit new targets will be required. Here we de... Fluorescence Lifetime of Fluorescent Proteins as an Intracellular Environment Probe Sensing the Cell Cycle Progression [作者：PLISS ARTEM; ZHAO LINGLING; OHULCHANSKYY TYMISH Y; QU JUNLE; PRASAD PARAS N,期刊：ACS CHEMICAL BIOLOGY, 页码：1385-1392 , 文章类型： Article，,卷期：2012年7-8] The fluorescence lifetime of fluorescent proteins is affected by the concentration of solutes in a medium, in inverse correlation with local refractive index. In this paper, we introduce the concept of using this depende... Development of a Highly Selective c-Src Kinase Inhibitor [作者：BRANDVOLD KRISTOFFER R; STEFFEY MICHAEL E; FOX CHRISTEL C; SOELLNER MATTHEW B,期刊：ACS CHEMICAL BIOLOGY, 页码：1393-1398 , 文章类型： Article，,卷期：2012年7-8] Generating highly selective probes to interrogate protein kinase function in biological studies remains a challenge, and new strategies are required. Herein, we describe the development of the first highly selective and ... Rethinking Molecular Similarity: Comparing Compounds on the Basis of Biological Activity [作者：PETRONE FAULA M; SIMMS BENJAMIN; NIGSCH FLORIAN; LOUNKINE EUGEN; KUTCHUKIAN PETER; CORNETT ALLEN; DENG ZHAN; DAVIES JOHN W; JENKINS JEREMY L; GLICK MEIR,期刊：ACS CHEMICAL BIOLOGY, 页码：1399-1409 , 文章类型： Article，,卷期：2012年7-8] Since the advent of high-throughput screening (HTS), there has been an urgent need for methods that facilitate the interrogation of large-scale chemical biology data to build a mode of action (MoA) hypothesis. This can b... Calpain 10 Homology Modeling with CYGAK and Increased Lipophilicity Leads to Greater Potency and Efficacy in Cells [作者：SMITH MATTHEW A; MCINNES CAMPBELL; WHITAKER RYAN M; LINDSEY CHRISTOPHER C; COMER RICHARD F; BEESON CRAIG C; SCHNELLMANN RICK G,期刊：ACS CHEMICAL BIOLOGY, 页码：1410-1419 , 文章类型： Article，,卷期：2012年7-8] Calpain 10 is a ubiquitously expressed mitochondrial and cytosolic Ca2+-regulated cysteine protease in which overexpression or knockdown leads to mitochondrial dysfunction and cell death. We previously identified a poten... Phosphorylation of the Synthetic Hexasaccharide Repeating Unit Is Essential for the Induction of Antibodies to Clostridium difficile PSII Cell Wall Polysaccharide [作者：ADAMO ROBERTO; ROMANO MARIA R; BERTI FRANCESCO; LEUZZI ROSANNA; TONTINI MARTA; DANIELI ELISA; CAPPELLETTI EMILIA; CAKICI OSMAN S; SWENNEN ERWIN; PINTO VITTORIA; BROGIONI BARBARA; PROIETTI DANIELA; GALEOTTI CESIRA L; LAY LUIGI; MONTEIRO MARIO A; SCARSELLI MARIA; COSTANTINO PAOLO,期刊：ACS CHEMICAL BIOLOGY, 页码：1420-1428 , 文章类型： Article，,卷期：2012年7-8] Clostridium difficile is emerging worldwide as a major cause of nosocomial infections. The negatively charged PSII polysaccharide has been found in different strains of C. difficile and, thereby, represents an important ... Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture [作者：OWEN SHAWN C; DOAK ALLISON K; WASSAM PASCAL; SHOICHET MOLLY S; SHOICHET BRIAN K,期刊：ACS CHEMICAL BIOLOGY, 页码：1429-1435 , 文章类型： Article，,卷期：2012年7-8] Many small molecules, including bioactive molecules and approved drugs, spontaneously form colloidal aggregates in aqueous solution at micromolar concentrations. Though it is widely accepted that aggregation leads to art...