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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Mutagenesis of Isopentenyl Phosphate Kinase To Enhance Geranyl Phosphate Kinase Activity [作者：MABANGLO MARK F; PAN JIANJUNG; SHAKYA BINITA; POULTER C DALE,期刊：ACS CHEMICAL BIOLOGY, 页码：1241-1246 , 文章类型： Article，,卷期：2012年7-7] Isopentenyl phosphate kinase (IPK) catalyzes the ATP-dependent phosphorylation of isopentenyl phosphate (IP) to form isopentenyl diphosphate (IPP) during biosynthesis of isoprenoid metabolites in Archaea. The structure o... Regulation of Transcription through Light-Activation and Light-Deactivation of Triplex-Forming Oligonucleotides in Mammalian Cells [作者：GOVAN JEANE M; UPRETY RAJENDRA; HEMPHILL JAMES; LIVELY MARK O; DEITERS ALEXANDER,期刊：ACS CHEMICAL BIOLOGY, 页码：1247-1256 , 文章类型： Article，,卷期：2012年7-7] Triplex-forming oligonucleotides (TFOs) are efficient tools to regulate gene expression through the inhibition of transcription. Here, nucleobase-caging technology was applied to the temporal regulation of transcription ... Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors as Potential Antifungals [作者：GRUETTER CHRISTIAN; SIMARD JEFFREY R; MAYERWRANGOWSKI SVENJA C; SCHREIER PETER H; PEREZMARTIN JOSE; RICHTERS ANDRE; GETLIK MATTHAEUS; GUTBROD OLIVER; BRAUN CHRISTOPH A; BECK MICHAEL E; RAUH DANIEL,期刊：ACS CHEMICAL BIOLOGY, 页码：1257-1267 , 文章类型： Article，,卷期：2012年7-7] Protein kinases are key enzymes in the complex regulation of cellular processes in almost all living organisms. For this reason, protein kinases represent attractive targets to stop the growth of eukaryotic pathogens suc... Inhibition of Biocatalysis in [Fe-Fe] Hydrogenase by Oxygen: Molecular Dynamics and Density Functional Theory Calculations [作者：HONG GONGYI; PACHTER RUTH,期刊：ACS CHEMICAL BIOLOGY, 页码：1268-1275 , 文章类型： Article，,卷期：2012年7-7] Designing O-2-tolerant hydrogenases is a major challenge in applying [Fe-Fe]H(2)ases for H-2 production. The inhibition involves transport of oxygen through the enzyme to the H-cluster, followed by binding and subsequent... In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains [作者：SANCHEZ MATEO I; MARTINEZCOSTAS JOSE; GONZALEZ FRANCISCO; BERMUDEZ MARIA A; EUGENIO VAZQUEZ M; MASCARENAS JOSE L,期刊：ACS CHEMICAL BIOLOGY, 页码：1276-1280 , 文章类型： Article，,卷期：2012年7-7] Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for "on demand" spatiotemporal control of their in vivo nucleic acid binding, as well as for... Api88 Is a Novel Antibacterial Designer Peptide To Treat Systemic Infections with Multidrug-Resistant Gram-Negative Pathogens [作者：CZIHAL PATRICIA; KNAPPE DANIEL; FRITSCHE STEFANIE; ZAHN MICHAEL; BERTHOLD NICOLE; PIANTAVIGNA STEFANIA; MUELLER UWE; VAN DORPE SYLVIA; HERTH NICOLE; BINAS ANNEGRET; KOEHLER GABRIELE; DE SPIEGELEER BART; MARTIN LISANDRA L; NOLTE OLIVER; STRAETER NORBERT; ALBER GOTTFRIED; HOFFMANN RALF,期刊：ACS CHEMICAL BIOLOGY, 页码：1281-1291 , 文章类型： Article，,卷期：2012年7-7] The emergence of multiple-drug-resistant (MDR), bacterial pathogens in hospitals (nosocomial infections) presents a global threat of growing importance, especially for Gram-negative bacteria with extended spectrum beta-l... Expanding the Genetic Code of Caenorhabditis elegans Using Bacterial Aminoacyl-tRNA Synthetase/tRNA Pairs [作者：PARRISH ANGELA R; SHE XINGYU; XIANG ZHENG; COIN IRENE; SHEN ZHOUXIN; BRIGGS STEVEN P; DILLIN ANDREW; WANG LEI,期刊：ACS CHEMICAL BIOLOGY, 页码：1292-1302 , 文章类型： Article，,卷期：2012年7-7] The genetic code specifies 20 common amino acids and is largely preserved in both single and multicellular organisms. Unnatural amino acids (Uaas) have been genetically incorporated into proteins by using engineered orth... Antibody-Recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease [作者：MCENANEY PATRICK J; PARKER CHRISTOPHER G; ZHANG ANDREW X; SPIEGEL DAVID A,期刊：ACS CHEMICAL BIOLOGY, 页码：1139-1151 , 文章类型： Article，,卷期：2012年7-7] Synthetic immunology, the development of synthetic systems capable of modulating and/or manipulating immunological functions, represents an emerging field of research with manifold possibilities. One focus of this area h... A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma [作者：YUAN YUAN; WANG QIU; PAULK JOSHIAWA; KUBICEK STEFAN; KEMP MELISSA M; ADAMS DREW J; SHAMJI ALYKHAN F; WAGNER BRIDGET K; SCHREIBER STUART L,期刊：ACS CHEMICAL BIOLOGY, 页码：1152-1157 , 文章类型： Article，,卷期：2012年7-7] Post-translational modifications of histones alter chromatin structure and play key roles in gene expression and specification of cell states. Small molecules that target chromatin-modifying enzymes selectively are usefu... Structural Determinants of Protein Kinase CK2 Regulation by Autoinhibitory Polymerization [作者：LOLLI GRAZIANO; PINNA LORENZO A; BATTISTUTTA ROBERTO,期刊：ACS CHEMICAL BIOLOGY, 页码：1158-1163 , 文章类型： Article，,卷期：2012年7-7] CK2 is a Ser/Thr protein kinase essential for cell viability whose activity is anomalously high in several cancers. CK2 is a validated target for cancer therapy with one small molecule inhibitor in phase I clinical trial... A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis [作者：MAK PUIYING A; RAO SRINIVASA P S; TAN MAI PING; LIN XIUHUA; CHYBA JASON; TAY JOANN; NG SEOW HWEE; TAN BEE HUAT; CHERIAN JOSEPH; DURAISWAMY JEYARAJ; BIFANI PABLO; LIM VIVIAN; LEE BOON HENG; MA NGAI LING; BEER DAVID; THAYALAN PAMELA; KUHEN KELLI; CHATTERJEE ARNAB; SUPEK FRANTISEK; GLYNNE RICHARD; ZHENG JUN; BOSHOFF HELENA I; BARRY CLIFTON E III; DICK THOMAS; PETHE KEVIN; CAMACHO LUIS R,期刊：ACS CHEMICAL BIOLOGY, 页码：1190-1197 , 文章类型： Article，,卷期：2012年7-7] Growing evidence suggests that the presence of a subpopulation of hypoxic non-replicating, phenotypically drug-tolerant mycobacteria is responsible for the prolonged duration of tuberculosis treatment. The discovery of n... Novel Inhibitors for PRMT1 Discovered by High-Throughput Screening Using Activity-Based Fluorescence Polarization [作者：DILLON MYLES B C; BACHOVCHIN DANIEL A; BROWN STEVEN J; FINN M G; ROSEN HUGH; CRAVATT BENJAMIN F; MOWEN KERRI A,期刊：ACS CHEMICAL BIOLOGY, 页码：1198-1204 , 文章类型： Article，,卷期：2012年7-7] Protein arginine methyltransferases (PRMTs) catalyze the posttranslational methylation of arginine using S-adenosylmethionine (SAM) as a methyl-donor. The PRMT family is widely expressed and has been implicated in biolog... Identification of Drug Modulators Targeting Gene-Dosage Disease CMT1A [作者：JANG SUNGWOOK; LOPEZANIDO CAMILA; MACARTHUR RYAN; SVAREN JOHN; INGLESE JAMES,期刊：ACS CHEMICAL BIOLOGY, 页码：1205-1213 , 文章类型： Article，,卷期：2012年7-7] The structural integrity of myelin formed by Schwann cells in the peripheral nervous system (PNS) is required for proper nerve conduction and is dependent on adequate expression of myelin genes including peripheral myeli... Gene Silencing Activity of siRNA Molecules Containing Phosphorodithioate Substitutions [作者：YANG XIANBIN; SIERANT MALGORZATA; JANICKA MAGDALENA; PECZEK LUKASZ; MARTINEZ CARLOS; HASSELL TOM; LI NA; LI XIN; WANG TIANZHI; NAWROT BARBARA,期刊：ACS CHEMICAL BIOLOGY, 页码：1214-1220 , 文章类型： Article，,卷期：2012年7-7] Chemically synthesized small interfering RNAs (siRNAs) have been widely used to identify gene function and hold great potential in providing a new class of therapeutics. Chemical modifications are desired for therapeutic... Lysine-Specific Histone Demethylase 1 Inhibitors Control Breast Cancer Proliferation in ER alpha-Dependent and -Independent Manners [作者：POLLOCK JULIE A; LARREA MICHELLE D; JASPER JEFF S; MCDONNELL DONALD P; MCCAFFERTY DEWEY G,期刊：ACS CHEMICAL BIOLOGY, 页码：1221-1231 , 文章类型： Article，,卷期：2012年7-7] Lysine specific demethylase 1 (LSD1, also known as KDM1) is a histone modifying enzyme that regulates the expression of many genes important in cancer progression and proliferation. It is present in various transcription... A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Directly Sialylating Lewis(X) [作者：SUGIARTO GO; LAU KAM; QU JINGYAO; LI YANHONG; LIM SUNGHYUK; MU SHENGMAO; AMES JAMES B; FISHER ANDREW J; CHEN XI,期刊：ACS CHEMICAL BIOLOGY, 页码：1232-1240 , 文章类型： Article，,卷期：2012年7-7] Glycosyltransferases are important catalysts for enzymatic and chemoenzymatic synthesis of complex carbohydrates and glycoconjugates. The glycosylation efficiencies of wild-type glycosyltransferases vary considerably whe...