The asymmetric induction of chiral centers bearing a methyl group is a fundamental protocol for the synthesis of valuable molecules in biologically active compounds. However, the direct asymmetric methylation is typicall...
The aldol reaction is one of the most predominantly used reactions for the formation of C-C bonds in synthetic organic chemistry. The vinylogous extension of this fundamental C-C bond-forming reaction to nucleophilic com...
The palladium-catalyzed intramolecular N-arylation of the Blaise reaction intermediate, formed by reaction of nitriles with an in situ generated Reformatsky reagent from ethyl alpha-bromo-alpha-(2-bromophenyl)acetate and...
A convenient method has been developed for the preparation of a variety of 1,3-benzothiazole-2(3H)-thiones. The reaction proceeds from an o-haloaniline derivative and carbon disulfide in the presence of 1,8-diazabicyclo[...
(S)-5-Fluoro-2-(2,2,6,6-tetramethylpiperidin-1-yloxymethyl)-1-tosylindoline, a 2-methyleneoxy-substituted chiral indoline, was synthesized on multigram scale using an efficient copper-catalyzed enantioselective intramole...
We demonstrated the synthesis of chiral annulated six-membered-ring N-heterocyclic carbenes (6-NHC) and their adducts with water and alcohol. We also have shown the donating properties of chiral annulated 6-NHCs is betwe...
We have developed an efficient and general synthesis of ynimines based on an oxidative cross-coupling between imines and alkynylcopper reagents. Upon simple addition of 1,2-dimethylimidazole in the presence of oxygen, th...
A facile, mild, and efficient copper-catalyzed homocoupling of ketoximes involving N-O bond cleavage in the presence of sodium bisulfite (NaHSO3) has been developed. This reaction shows good functional group tolerance an...
The microwave-assisted, copper-catalyzed coupling of terminal alkynes with aryl iodides and vinyl halides is reported. In general, the reactions are completed in 10-30 min using 2-5 mol% [CuI(xantphos)] as a catalyst to ...
The ring opening of bicyclic hydrazines and bicyclic oxazines with organomagnesium reagents under the influence of copper catalysts allows functionalized cyclopentene and cyclohexene derivatives to be obtained. Whereas c...
A copper-promoted annulative direct coupling of o-alkynylaniline derivatives with 1,3,4-oxadiazoles for the synthesis of C3-azolylindoles has been developed. The copper-based system provides a new protocol for the dehydr...
Copper-catalyzed aerobic oxidative trifluoromethylation of readily accessible H-phosphonates was demonstrated for the first time. This method not only provides an alternative method for the facile synthesis of a series o...
Copper-catalyzed aerobic methyl/methylene oxygenation of substituted indoles and pyrroles was developed using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an additive in dimethyl sulfoxide (DMSO). Similar aerobic catalytic c...
A copper-catalyzed gamma-selective allyl-alkyl coupling between gamma-silylated allylic phosphates and alkylboron compounds (alkyl-9-BBN, prepared by hydroboration of alkenes with 9-BBN-H) produced allylsilanes. The reac...
Copper-catalyzed skeletal rearrangement of O-propargylic aryloximes (E)-1 were carried out to afford the corresponding four-membered cyclic nitrones 2 in good to excellent yields. The optimal reactions conditions of the ...
An efficient copper-catalyzed C-H oxidative cycloetherification of o-arylphenols containing an additional directing group under an oxygen atmosphere was developed. 2,6-Disubstituted dibenzofuran derivatives were prepared...