- Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
[作者：Sahu, B; Laakso, M; Ovaska, K; Mirtti, T; Lundin, J; Rannikko, A; Sankila, A; Turunen, JP; Lundin, M; Konsti, J; Vesterinen, T; Nordling, S; Kallioniemi, O; Hautaniemi, S; Janne, OA,期刊：EMBO journal, 页码：3962-3976 , 文章类型： Article，,卷期：2011年30-19]
- High androgen receptor (AR) level in primary tumour predicts increased prostate cancer-specific mortality. However, the mechanisms that regulate AR function in prostate cancer are poorly known. We report here a new parad...
- A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors
[作者：Handler, D; Olivieri, D; Novatchkova, M; Gruber, FS; Meixner, K; Mechtler, K; Stark, A; Sachidanandam, R; Brennecke, J,期刊：EMBO journal, 页码：3977-3993 , 文章类型： Article，,卷期：2011年30-19]
- PIWI proteins and their bound PIWI-interacting RNAs (piRNAs) form the core of a gonad-specific small RNA silencing pathway that protects the animal genome against the deleterious activity of transposable elements. Recent...
- Nucleophosmin deposition during mRNA 3 ' end processing influences poly(A) tail length
[作者：Sagawa, F; Ibrahim, H; Morrison, AL; Wilusz, CJ; Wilusz, J,期刊：EMBO journal, 页码：3994-4005 , 文章类型： Article，,卷期：2011年30-19]
- During polyadenylation, the multi-functional protein nucleophosmin (NPM1) is deposited onto all cellular mRNAs analysed to date. Premature termination of poly(A) tail synthesis in the presence of cordycepin abrogates dep...
- Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S pre-rRNA processing
[作者：Sahasranaman, A; Dembowski, J; Strahler, J; Andrews, P; Maddock, J; Woolford, JL,期刊：EMBO journal, 页码：4020-4032 , 文章类型： Article，,卷期：2011年30-19]
- The precise functions of most of the similar to 200 assembly factors and 79 ribosomal proteins required to construct yeast ribosomes in vivo remain largely unexplored. To better understand the roles of these proteins and...
- G-quadruplex-induced instability during leading-strand replication
[作者：Lopes, J; Piazza, A; Bermejo, R; Kriegsman, B; Colosio, A; Teulade-Fichou, MP; Foiani, M; Nicolas, A,期刊：EMBO journal, 页码：4033-4046 , 文章类型： Article，,卷期：2011年30-19]
- G-quadruplexes are four-stranded nucleic acid structures whose biological functions remain poorly understood. In the yeast S. cerevisiae, we report that G-quadruplexes form and, if not properly processed, pose a specific...
- Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
[作者：Chawla, R; Redon, S; Raftopoulou, C; Wischnewski, H; Gagos, S; Azzalin, CM,期刊：EMBO journal, 页码：4047-4058 , 文章类型： Article，,卷期：2011年30-19]
- Eukaryotic up-frameshift 1 (UPF1) is a nucleic acid-dependent ATPase and 5'-to-3' helicase, best characterized for its roles in cytoplasmic RNA quality control. We previously demonstrated that human UPF1 binds to telomer...
- Rac1 activation comes full circle
[作者：Symons, M,期刊：EMBO journal, 页码：3875-3877 , 文章类型： Editorial Material，,卷期：2011年30-19]
- The Rac1 small GTPase is responsive to a large array of extracellular signals and in turn controls a wide variety of cellular functions-including actin dynamics. New findings add an additional layer of intricacy to the a...
- G4 DNA: at risk in the genome
[作者：Davis, L; Maizels, N,期刊：EMBO journal, 页码：3878-3879 , 文章类型： Editorial Material，,卷期：2011年30-19]
- Regions bearing G-quadruplex (G4) DNA motifs can be sites of genomic instability and are frequently depleted in streamlined genomes, but are nevertheless maintained in many other genomes. Whether G4 secondary structures ...
- von Willebrand factor folds into a bouquet
[作者：Gerke, V,期刊：EMBO journal, 页码：3880-3881 , 文章类型： Editorial Material，,卷期：2011年30-19]
- The large glycoprotein von Willebrand factor (vWF) serves an important role in orchestrating the blood vessel's response to injury. It is released from activated endothelial cells and forms long multimeric strings that b...
- FOXA1: master of steroid receptor function in cancer
[作者：Augello, MA; Hickey, TE; Knudsen, KE,期刊：EMBO journal, 页码：3885-3894 , 文章类型： Review，,卷期：2011年30-19]
- FOXA transcription factors are potent, context-specific mediators of development that hold specialized functions in hormone-dependent tissues. Over the last several years, FOXA1 has emerged as a critical mediator of nucl...
- Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation
[作者：Quintana, A; Pasche, M; Junker, C; Al-Ansary, D; Rieger, H; Kummerow, C; Nunez, L; Villalobos, C; Meraner, P; Becherer, U; Rettig, J; Niemeyer, BA; Hoth, M,期刊：EMBO journal, 页码：3895-3912 , 文章类型： Article，,卷期：2011年30-19]
- Cell polarization enables restriction of signalling into microdomains. Polarization of lymphocytes following formation of a mature immunological synapse (IS) is essential for calcium-dependent T-cell activation. Here, we...
- Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation
[作者：Castro-Castro, A; Ojeda, V; Barreira, M; Sauzeau, V; Navarro-Lerida, I; Muriel, O; Couceiro, JR; Pimentel-Muinos, FX; del Pozo, MA; Bustelo, XR,期刊：EMBO journal, 页码：3913-3927 , 文章类型： Article，,卷期：2011年30-19]
- The activation of the Rac1 GTPase during cell signalling entails its translocation from the cytosol to membranes, release from sequestering Rho GDP dissociation inhibitors (RhoGDI), and GDP/GTP exchange. In addition to t...
- Mechanism of transcriptional repression at a bacterial promoter by analysis of single molecules
[作者：Sanchez, A; Osborne, ML; Friedman, LJ; Kondev, J; Gelles, J,期刊：EMBO journal, 页码：3940-3946 , 文章类型： Article，,卷期：2011年30-19]
- The molecular basis for regulation of lactose metabolism in Escherichia coli is well studied. Nonetheless, the physical mechanism by which the Lac repressor protein prevents transcription of the lactose promoter remains ...
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