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[摘要]：Centromeres are epigenetically defined by the presence of the histone H3 variant, CENP-A. Up until now, the question of how CENP-A nucleosomes mediate kinetochore nucleation was poorly understood. In a study just published in Nature, a unique cell-free system was used to demonstrate that in vitro assembled CENP-A chromatin arrays recapitulate the assembly of bona fide kinetochores through the essential C-terminal tail of CENP-A. |
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