- Duelling functions of the V-ATPase
[作者：Scott, CC; Bissig, C; Gruenberg, J,期刊：EMBO journal, 页码：4113-4115 , 文章类型： Editorial Material，,卷期：2011年30-20]
- The V-ATPase, the major cellular proton pump, is comprised of the peripheral sector V1 catalysing ATP hydrolysis and the membrane integral sector V0 translocating protons. Ten years ago, Andreas Mayer's group made the su...
- Releasing a tiny molecular brake may improve memory
[作者：Fiore, R; Schratt, G,期刊：EMBO journal, 页码：4116-4118 , 文章类型： Editorial Material，,卷期：2011年30-20]
- Understanding the molecular pathways underlying cognitive decline during neurodegenerative diseases is essential to design effective therapeutic strategies. In this issue of The EMBO Journal, Zovoilis et al identify miR-...
- After half a century mitochondrial calcium in- and efflux machineries reveal themselves
[作者：Drago, I; Pizzo, P; Pozzan, T,期刊：EMBO journal, 页码：4119-4125 , 文章类型： Review，,卷期：2011年30-20]
- Mitochondrial Ca(2+) uptake and release play a fundamental role in the control of different physiological processes, such as cytoplasmic Ca(2+) signalling, ATP production and hormone metabolism, while dysregulation of mi...
- Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin
[作者：Kaluza, D; Kroll, J; Gesierich, S; Yao, TP; Boon, RA; Hergenreider, E; Tjwa, M; Rossig, L; Seto, E; Augustin, HG; Zeiher, AM; Dimmeler, S; Urbich, C,期刊：EMBO journal, 页码：4142-4156 , 文章类型： Article，,卷期：2011年30-20]
- Histone deacetylases (HDACs) deacetylate histones and non-histone proteins, thereby affecting protein activity and gene expression. The regulation and function of the cytoplasmic class IIb HDAC6 in endothelial cells (ECs...
- Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability
[作者：Schulte, D; Kuppers, V; Dartsch, N; Broermann, A; Li, H; Zarbock, A; Kamenyeva, O; Kiefer, F; Khandoga, A; Massberg, S; Vestweber, D,期刊：EMBO journal, 页码：4157-4170 , 文章类型： Article，,卷期：2011年30-20]
- To determine whether leukocytes need to open endothelial cell contacts during extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To this end, we replaced VE-cadherin genetically by...
- A thermodynamic switch modulates abscisic acid receptor sensitivity
[作者：Dupeux, F; Santiago, J; Betz, K; Twycross, J; Park, SY; Rodriguez, L; Gonzalez-Guzman, M; Jensen, MR; Krasnogor, N; Blackledge, M; Holdsworth, M; Cutler, SR; Rodriguez, PL; Marquez, JA,期刊：EMBO journal, 页码：4171-4184 , 文章类型： Article，,卷期：2011年30-20]
- Abscisic acid (ABA) is a key hormone regulating plant growth, development and the response to biotic and abiotic stress. ABA binding to pyrabactin resistance (PYR)/PYR1-like (PYL)/Regulatory Component of Abscisic acid Re...
- Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity
[作者：Miertzschke, M; Koerner, C; Vetter, IR; Keilberg, D; Hot, E; Leonardy, S; Sogaard-Andersen, L; Wittinghofer, A,期刊：EMBO journal, 页码：4185-4197 , 文章类型： Article，,卷期：2011年30-20]
- The bacterium Myxococcus xanthus uses a G protein cycle to dynamically regulate the leading/lagging pole polarity axis. The G protein MglA is regulated by its GTPase-activating protein (GAP) MglB, thus resembling Ras fam...
- H3K4 tri-methylation provides an epigenetic signature of active enhancers
[作者：Pekowska, A; Benoukraf, T; Zacarias-Cabeza, J; Belhocine, M; Koch, F; Holota, H; Imbert, J; Andrau, JC; Ferrier, P; Spicuglia, S,期刊：EMBO journal, 页码：4198-4210 , 文章类型： Article，,卷期：2011年30-20]
- Combinations of post-translational histone modifications shape the chromatin landscape during cell development in eukaryotes. However, little is known about the modifications exactly delineating functionally engaged regu...
- Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects
[作者：Marcucci, R; Brindle, J; Paro, S; Casadio, A; Hempel, S; Morrice, N; Bisso, A; Keegan, LP; Del Sal, G; O'Connell, MA,期刊：EMBO journal, 页码：4211-4222 , 文章类型： Article，,卷期：2011年30-20]
- ADAR2 catalyses the deamination of adenosine to inosine at the GluR2 Q/R site in the pre-mRNA encoding the critical subunit of AMPA receptors. Among ADAR2 substrates this is the vital one as editing at this position is i...
- An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer
[作者：Barraud, P; Emmerth, S; Shimada, Y; Hotz, HR; Allain, FHT; Buhler, M,期刊：EMBO journal, 页码：4223-4235 , 文章类型： Article，,卷期：2011年30-20]
- Dicer proteins function in RNA interference (RNAi) pathways by generating small RNAs (sRNAs). Here, we report the solution structure of the C-terminal domain of Schizosaccharomyces pombe Dicer (Dcr1). The structure revea...
- Structure of the SSB-DNA polymerase III interface and its role in DNA replication
[作者：Marceau, AH; Bahng, S; Massoni, SC; George, NP; Sandler, SJ; Marians, KJ; Keck, JL,期刊：EMBO journal, 页码：4236-4247 , 文章类型： Article，,卷期：2011年30-20]
- Interactions between single-stranded DNA-binding proteins (SSBs) and the DNA replication machinery are found in all organisms, but the roles of these contacts remain poorly defined. In Escherichia coli, SSB's association...
- LPA-producing enzyme PA-PLA(1)alpha regulates hair follicle development by modulating EGFR signalling
[作者：Inoue, A; Arima, N; Ishiguro, J; Prestwich, GD; Arai, H; Aoki, J,期刊：EMBO journal, 页码：4248-4260 , 文章类型： Article，,卷期：2011年30-20]
- Recent genetic studies of human hair disorders have suggested a critical role of lysophosphatidic acid (LPA) signalling in hair follicle development, mediated by an LPA-producing enzyme, phosphatidic acid-selective phosp...
- iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
[作者：Chikh, A; Matin, RNH; Senatore, V; Hufbauer, M; Lavery, D; Raimondi, C; Ostano, P; Mello-Grand, M; Ghimenti, C; Bahta, A; Khalaf, S; Akgul, B; Braun, KM; Chiorino, G; Philpott, MP; Harwood, CA; Bergamaschi, D,期刊：EMBO journal, 页码：4261-4273 , 文章类型： Article，,卷期：2011年30-20]
- iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers. However, little is known about the ...
- PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression
[作者：Chan, CB; Chen, YJ; Liu, X; Tang, XL; Lee, CW; Mei, L; Ye, KQ,期刊：EMBO journal, 页码：4274-4286 , 文章类型： Article，,卷期：2011年30-20]
- AMPAR (alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor) is an ion channel involved in the formation of synaptic plasticity. However, the molecular mechanism that couples plasticity stimuli to the traff...
- CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement
[作者：Lopez-Atalaya, JP; Ciccarelli, A; Viosca, J; Valor, LM; Jimenez-Minchan, M; Canals, S; Giustetto, M; Barco, A,期刊：EMBO journal, 页码：4287-4298 , 文章类型： Article，,卷期：2011年30-20]
- The epigenetic changes of the chromatin represent an attractive molecular substrate for adaptation to the environment. We examined here the role of CREB-binding protein (CBP), a histone acetyltransferase involved in ment...
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