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[摘要]:Understanding the molecular pathways underlying cognitive decline during neurodegenerative diseases is essential to design effective therapeutic strategies. In this issue of The EMBO Journal, Zovoilis et al identify miR-34c as a hippocampal-specific microRNA up-regulated in ageing and neurodegeneration. Cognitive deficits in aged mice and Alzheimer mouse models could be rescued by inhibiting miR-34c or by preventing the interaction between miR-34c and its target SIRT1. Thus, miR-34c might be both a marker for the onset of memory impairments and a promising target for therapeutic approaches in dementia. |
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