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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3(-/+) mice [作者：Morita, M; Oike, Y; Nagashima, T; Kadomatsu, T; Tabata, M; Suzuki, T; Nakamura, T; Yoshida, N; Okada, M; Yamamoto, T,期刊：EMBO journal, 页码：4678-4691 , 文章类型： Article，,卷期：2011年30-22] Obesity is a life-threatening factor and is often associated with dysregulation of gene expression. Here, we show that the CNOT3 subunit of the CCR4-NOT deadenylase complex is critical to metabolic regulation. Cnot3(-/+)... Autophagy regulation by miRNAs: when cleaning goes out of service [作者：Cecconi, F,期刊：EMBO journal, 页码：4517-4519 , 文章类型： Editorial Material，,卷期：2011年30-22] Autophagy is a degradation pathway, recycling cell components in a number of basal and sublethal stress conditions. The formation of specific vesicles (autophagosomes), carrying their content to the lysosome, is primed b... When zip codes are in short supply [作者：Perry, RB; Fainzilber, M,期刊：EMBO journal, 页码：4520-4522 , 文章类型： Editorial Material，,卷期：2011年30-22] beta-Actin mRNA requires the RNA-binding protein ZBP1 for trafficking to distal regions of the cytoplasm. In this issue of The EMBO Journal, Donnelly et al show that ZBP1 is a limiting and essential factor for adult axon... A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome [作者：Dodding, MP; Mitter, R; Humphries, AC; Way, M,期刊：EMBO journal, 页码：4523-4538 , 文章类型： Article，,卷期：2011年30-22] Transport of cargoes by kinesin-1 is essential for many cellular processes. Nevertheless, the number of proteins known to recruit kinesin-1 via its cargo binding light chain (KLC) is still quite small. We also know relat... Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)(2) synthesis [作者：Legate, KR; Takahashi, S; Bonakdar, N; Fabry, B; Boettiger, D; Zent, R; Fassler, R,期刊：EMBO journal, 页码：4539-4553 , 文章类型： Article，,卷期：2011年30-22] The 90-kDa isoform of the lipid kinase PIP kinase Type I c (PIPKI gamma) localizes to focal adhesions (FAs), where it provides a local source of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)). Although PtdIns(4,... FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function [作者：Jensen, KS; Binderup, T; Jensen, KT; Therkelsen, I; Borup, R; Nilsson, E; Multhaupt, H; Bouchard, C; Quistorff, B; Kjaer, A; Landberg, G; Staller, P,期刊：EMBO journal, 页码：4554-4570 , 文章类型： Article，,卷期：2011年30-22] Exposure of metazoan organisms to hypoxia engages a metabolic switch orchestrated by the hypoxia-inducible factor 1 (HIF-1). HIF-1 mediates induction of glycolysis and active repression of mitochondrial respiration that ... IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes [作者：Restivo, G; Nguyen, BC; Dziunycz, P; Ristorcelli, E; Ryan, RJH; Ozuysal, OY; Di Piazza, M; Radtke, F; Dixon, MJ; Hofbauer, GFL; Lefort, K; Dotto, GP,期刊：EMBO journal, 页码：4571-4585 , 文章类型： Article，,卷期：2011年30-22] While the pro-differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain poorly understood. We report here that interferon regulatory fact... Jarid1b targets genes regulating development and is involved in neural differentiation [作者：Schmitz, SU; Albert, M; Malatesta, M; Morey, L; Johansen, JV; Bak, M; Tommerup, N; Abarrategui, I; Helin, K,期刊：EMBO journal, 页码：4586-4600 , 文章类型： Article，,卷期：2011年30-22] H3K4 methylation is associated with active transcription and in combination with H3K27me3 thought to keep genes regulating development in a poised state. The contribution of enzymes regulating trimethylation of lysine 4 ... The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline [作者：Pane, A; Jiang, P; Zhao, DY; Singh, M; Schupbach, T,期刊：EMBO journal, 页码：4601-4615 , 文章类型： Article，,卷期：2011年30-22] In a broad range of organisms, Piwi-interacting RNAs (piRNAs) have emerged as core components of a surveillance system that protects the genome by silencing transposable and repetitive elements. A vast proportion of piRN... Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference [作者：Beloglazova, N; Petit, P; Flick, R; Brown, G; Savchenko, A; Yakunin, AF,期刊：EMBO journal, 页码：4616-4627 , 文章类型： Article，,卷期：2011年30-22] Clustered regularly interspaced short palindromic repeats (CRISPRs) and Cas proteins represent an adaptive microbial immunity system against viruses and plasmids. Cas3 proteins have been proposed to play a key role in th... microRNA-101 is a potent inhibitor of autophagy [作者：Frankel, LB; Wen, JY; Lees, M; Hoyer-Hansen, M; Farkas, T; Krogh, A; Jaattela, M; Lund, AH,期刊：EMBO journal, 页码：4628-4641 , 文章类型： Article，,卷期：2011年30-22] Autophagy is an evolutionarily conserved mechanism of cellular self-digestion in which proteins and organelles are degraded through delivery to lysosomes. Defects in this process are implicated in numerous human diseases... Temporal orchestration of circadian autophagy rhythm by C/EBP beta [作者：Ma, D; Panda, S; Lin, JDD,期刊：EMBO journal, 页码：4642-4651 , 文章类型： Article，,卷期：2011年30-22] Temporal organization of tissue metabolism is important for maintaining nutrient and energy homeostasis in mammals. Autophagy is a conserved cellular pathway that is activated in response to nutrient limitation, resultin... Arrangement of electron transport chain components in bovine mitochondrial supercomplex I(1)III(2)IV(1) [作者：Althoff, T; Mills, DJ; Popot, JL; Kuhlbrandt, W,期刊：EMBO journal, 页码：4652-4664 , 文章类型： Article，,卷期：2011年30-22] The respiratory chain in the inner mitochondrial membrane contains three large multi-enzyme complexes that together establish the proton gradient for ATP synthesis, and assemble into a supercomplex. A 19-angstrom 3D map ... Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity [作者：Donnelly, CJ; Willis, DE; Xu, M; Tep, C; Jiang, CS; Yoo, S; Schanen, NC; Kirn-Safran, CB; van Minnen, J; English, A; Yoon, SO; Bassell, GJ; Twiss, JL,期刊：EMBO journal, 页码：4665-4677 , 文章类型： Article，,卷期：2011年30-22] Subcellular localization of mRNAs is regulated by RNA-protein interactions. Here, we show that introduction of a reporter mRNA with the 30UTR of beta-actin mRNA competes with endogenous mRNAs for binding to ZBP1 in adult...