- Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1 beta
[作者：Dupont, N; Jiang, SY; Pilli, M; Ornatowski, W; Bhattacharya, D; Deretic, V,期刊：EMBO journal, 页码：4701-4711 , 文章类型： Article，,卷期：2011年30-23]
- Autophagy controls the quality and quantity of the eukaryotic cytoplasm while performing two evolutionarily highly conserved functions: cell-autonomous provision of energy and nutrients by cytosol autodigestion during st...
- Regulation of integrin affinity on cell surfaces
[作者：Schurpf, T; Springer, TA,期刊：EMBO journal, 页码：4712-4727 , 文章类型： Article，,卷期：2011年30-23]
- Lymphocyte activation triggers adhesiveness of lymphocyte function-associated antigen-1 (LFA-1; integrin alpha(L)beta(2)) for intercellular adhesion molecules (ICAMs) on endothelia or antigen-presenting cells. Whether th...
- NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons
[作者：Yokoyama, K; Tezuka, T; Kotani, M; Nakazawa, T; Hoshina, N; Shimoda, Y; Kakuta, S; Sudo, K; Watanabe, K; Iwakura, Y; Yamamoto, T,期刊：EMBO journal, 页码：4739-4754 , 文章类型： Article，,卷期：2011年30-23]
- The phosphoinositide 3-kinase (PI3K) pathway has been extensively studied in neuronal function and morphogenesis. However, the precise molecular mechanisms of PI3K activation and its downstream signalling in neurons rema...
- Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer
[作者：Zwart, W; Theodorou, V; Kok, M; Canisius, S; Linn, S; Carroll, JS,期刊：EMBO journal, 页码：4764-4776 , 文章类型： Article，,卷期：2011年30-23]
- The complexity of oestrogen receptor alpha (ER alpha)-mediated transcription is becoming apparent, but global insight into the co-regulatory proteins that assist ER alpha transcription is incomplete. Here, we present the...
- Ablation of Smurf2 reveals an inhibition in TGF-beta signalling through multiple mono-ubiquitination of Smad3
[作者：Tang, LY; Yamashita, M; Coussens, NP; Tang, Y; Wang, XC; Li, CL; Deng, CX; Cheng, SY; Zhang, YE,期刊：EMBO journal, 页码：4777-4789 , 文章类型： Article，,卷期：2011年30-23]
- TGF-beta signalling is regulated by post-translational modifications of Smad proteins to translate quantitative difference in ligand concentration into proportional transcriptional output. Previous studies in cell cultur...
- The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation
[作者：Tang, CJC; Lin, SY; Hsu, WB; Lin, YN; Wu, CT; Lin, YC; Chang, CW; Wu, KS; Tang, TK,期刊：EMBO journal, 页码：4790-4804 , 文章类型： Article，,卷期：2011年30-23]
- Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary microcephaly (MCPH). Here, we show that human STIL has an asymmetric localization...
- New WAVEs in neuronal PI3K signalling
[作者：Mack, TGA; Eickholt, BJ,期刊：EMBO journal, 页码：4693-4695 , 文章类型： Editorial Material，,卷期：2011年30-23]
- The processes involved in the formation of the nervous system require the function of a multitude of proteins, which regulate a diverse array of cellular responses. The PI3K signalling pathway has emerged as being centra...
- Target of gamma-secretase modulators, presenilin marks the spot
[作者：Crump, CJ; Johnson, DS; Li, YM,期刊：EMBO journal, 页码：4696-4698 , 文章类型： Editorial Material，,卷期：2011年30-23]
- gamma-Secretase modulators, or GSMs, which reduce the production of A beta 42, have emerged as a promising class of compounds for the treatment of Alzheimer's disease (AD). The target and mechanism of action of GSMs have...
- Di-rectifying Tau
[作者：Jha, S; Rasband, MN,期刊：EMBO journal, 页码：4699-4700 , 文章类型： Editorial Material，,卷期：2011年30-23]
- In this issue of The EMBO Journal, Li et al (2011) show that the axon initial segment (AIS) functions as a retrograde trafficking barrier, or axonal rectifier, to exclude axonal Tau from re-entry into the somatodendritic...
- Phenylpiperidine-type gamma-secretase modulators target the transmembrane domain 1 of presenilin 1
[作者：Ohki, Y; Higo, T; Uemura, K; Shimada, N; Osawa, S; Berezovska, O; Yokoshima, S; Fukuyama, T; Tomita, T; Iwatsubo, T,期刊：EMBO journal, 页码：4815-4824 , 文章类型： Article，,卷期：2011年30-23]
- Amyloid-beta peptide ending at the 42nd residue (A beta 42) is implicated in the pathogenesis of Alzheimer's disease (AD). Small compounds that exhibit selective lowering effects on A beta 42 production are termed gamma-...
- Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration
[作者：Li, XY; Kumar, Y; Zempel, H; Mandelkow, EM; Biernat, J; Mandelkow, E,期刊：EMBO journal, 页码：4825-4837 , 文章类型： Article，,卷期：2011年30-23]
- Missorting of Tau from axons to the somatodendritic compartment of neurons is a hallmark of Alzheimer's disease, but the mechanisms underlying normal sorting and pathological failure are poorly understood. Here, we used ...
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