Di-rectifying Tau

[摘要]：In this issue of The EMBO Journal, Li et al (2011) show that the axon initial segment (AIS) functions as a retrograde trafficking barrier, or axonal rectifier, to exclude axonal Tau from re-entry into the somatodendritic compartment. They elucidate the molecular basis of this rectification by showing that hyperphosphorylation of Tau permits it to detach from microtubules (MTs) and bypass the retrograde barrier.

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