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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Human pluripotent stem cells decouple respiration from energy production [作者：Shyh-Chang, N; Zheng, YX; Locasale, JW; Cantley, LC,期刊：EMBO journal, 页码：4851-4852 , 文章类型： Editorial Material，,卷期：2011年30-24] Human pluripotent stem cells (hPSCs) rely heavily on glycolysis for energy metabolism, and because their mitochondria appear poorly developed, hPSCs have been assumed to be incapable of using oxidative phosphorylation (O... Building a double hexamer of DNA helicase at eukaryotic replication origins [作者：Labib, K,期刊：EMBO journal, 页码：4853-4855 , 文章类型： Editorial Material，,卷期：2011年30-24] The Mcm2-7 complex, the catalytic core of the eukaryotic replicative DNA helicase, undergoes a complex series of transformations at origins of DNA replication. During G1 phase, it is loaded around double-strand DNA at or... Rotate into shape: MreB and bacterial morphogenesis [作者：van Teeffelen, S; Gitai, Z,期刊：EMBO journal, 页码：4856-4857 , 文章类型： Editorial Material，,卷期：2011年30-24] MreB, the bacterial actin homologue, plays a vital role in determining cell shape, but the mechanisms by which it actually functions have remained largely mysterious. Recent studies now shed new light on MreB, demonstrat... The unmasking of novel unipotent stem cells in the mammary gland [作者：Visvader, JE; Lindeman, GJ,期刊：EMBO journal, 页码：4858-4859 , 文章类型： Article，,卷期：2011年30-24] Mammary stem cells (MaSCs) have been prospectively isolated and shown to reconstitute a fully functional mammary gland in the mouse at the single cell level. These cells are self-renewing and can differentiate into all m... UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells [作者：Zhang, J; Khvorostov, I; Hong, JS; Oktay, Y; Vergnes, L; Nuebel, E; Wahjudi, PN; Setoguchi, K; Wang, G; Do, A; Jung, HJ; McCaffery, JM; Kurland, IJ; Reue, K; Lee, WNP; Koehler, CM; Teitell, MA,期刊：EMBO journal, 页码：4860-4873 , 文章类型： Article，,卷期：2011年30-24] It has been assumed, based largely on morphologic evidence, that human pluripotent stem cells (hPSCs) contain underdeveloped, bioenergetically inactive mitochondria. In contrast, differentiated cells harbour a branched m... FGF signalling inhibits neural induction in human embryonic stem cells [作者：Greber, B; Coulon, P; Zhang, M; Moritz, S; Frank, S; Muller-Molina, AJ; Arauzo-Bravo, MJ; Han, DW; Pape, HC; Scholer, HR,期刊：EMBO journal, 页码：4874-4884 , 文章类型： Article，,卷期：2011年30-24] Human embryonic stem cells (hESCs) can exit the self-renewal programme, through the action of signalling molecules, at any given time and differentiate along the three germ layer lineages. We have systematically investig... Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases [作者：Takara, TJ; Bell, SP,期刊：EMBO journal, 页码：4885-4896 , 文章类型： Article，,卷期：2011年30-24] Eukaryotic origins of replication are selected by loading a head-to-head double hexamer of the Mcm2-7 replicative helicase around origin DNA. Cdt1 plays an essential but transient role during this event; however, its mec... Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment [作者：Pfander, B; Diffley, JFX,期刊：EMBO journal, 页码：4897-4907 , 文章类型： Article，,卷期：2011年30-24] Eukaryotic cells respond to DNA damage by activating checkpoint signalling pathways. Checkpoint signals are transduced by a protein kinase cascade that also requires non-kinase mediator proteins. One such mediator is the... Inhibition of autophagy by TAB2 and TAB3 [作者：Criollo, A; Niso-Santano, M; Malik, SA; Michaud, M; Morselli, E; Marino, G; Lachkar, S; Arkhipenko, AV; Harper, F; Pierron, G; Rain, JC; Ninomiya-Tsuji, J; Fuentes, JM; Lavandero, S; Galluzzi, L; Maiuri, MC; Kroemer, G,期刊：EMBO journal, 页码：4908-4920 , 文章类型： Article，,卷期：2011年30-24] Autophagic responses are coupled to the activation of the inhibitor of NF-kappa B kinase 9IKK). Here, we report that the essential autophagy mediator Beclin 1 and TGF beta-activated kinase 1 9TAK1)-binding proteins 2 and... Regulation of p53 stability and function by the deubiquitinating enzyme USP42 [作者：Hock, AK; Vigneron, AM; Carter, S; Ludwig, RL; Vousden, KH,期刊：EMBO journal, 页码：4921-4930 , 文章类型： Article，,卷期：2011年30-24] The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly reg... A widespread family of bacterial cell wall assembly proteins [作者：Kawai, Y; Marles-Wright, J; Cleverley, RM; Emmins, R; Ishikawa, S; Kuwano, M; Heinz, N; Bui, NK; Hoyland, CN; Ogasawara, N; Lewis, RJ; Vollmer, W; Daniel, RA; Errington, J,期刊：EMBO journal, 页码：4931-4941 , 文章类型： Article，,卷期：2011年30-24] Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge a... Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry [作者：Gerson-Gurwitz, A; Thiede, C; Movshovich, N; Fridman, V; Podolskaya, M; Danieli, T; Lakamper, S; Klopfenstein, DR; Schmidt, CF; Gheber, L,期刊：EMBO journal, 页码：4942-4954 , 文章类型： Article，,卷期：2011年30-24] Kinesin-5 motors fulfil essential roles in mitotic spindle morphogenesis and dynamics as slow, processive microtubule (MT) plus-end directed motors. The Saccharomyces cerevisiae kinesin-5 Cin8 was found, surprisingly, to... Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I [作者：Koch, D; Spiwoks-Becker, I; Sabanov, V; Sinning, A; Dugladze, T; Stellmacher, A; Ahuja, R; Grimm, J; Schuler, S; Muller, A; Angenstein, F; Ahmed, T; Diesler, A; Moser, M; Dieck, ST; Spessert, R; Boeckers, TM; Fassler, R; Hubner, CA; Balschun, D; Gloveli, T; Kessels, MM; Qualmann, B,期刊：EMBO journal, 页码：4955-4969 , 文章类型： Article，,卷期：2011年30-24] Synaptic transmission relies on effective and accurate compensatory endocytosis. F-BAR proteins may serve as membrane curvature sensors and/or inducers and thereby support membrane remodelling processes; yet, their in vi... OCRL controls trafficking through early endosomes via PtdIns4,5P(2)-dependent regulation of endosomal actin [作者：Vicinanza, M; Di Campli, A; Polishchuk, E; Santoro, M; Di Tullio, G; Godi, A; Levtchenko, E; De Leo, MG; Polishchuk, R; Sandoval, L; Marzolo, MP; De Matteis, MA,期刊：EMBO journal, 页码：4970-4985 , 文章类型： Article，,卷期：2011年30-24] Mutations in the phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P(2)) 5-phosphatase OCRL cause Lowe syndrome, which is characterised by congenital cataracts, central hypotonia, and renal proximal tubular dysfunction. Pr... Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules [作者：Zhu, JW; Shang, Y; Xia, CH; Wang, WN; Wen, WY; Zhang, MJ,期刊：EMBO journal, 页码：4986-4997 , 文章类型： Article，,卷期：2011年30-24] Membrane-associated guanylate kinases (MAGUKs) are a large family of scaffold proteins that play essential roles in tissue developments, cell-cell communications, cell polarity control, and cellular signal transductions.... PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro [作者：Fukaya, T; Tomari, Y,期刊：EMBO journal, 页码：4998-5009 , 文章类型： Article，,卷期：2011年30-24] MicroRNAs silence their complementary target genes via formation of the RNA-induced silencing complex (RISC) that contains an Argonaute (Ago) protein at its core. It was previously proposed that GW182, an Ago-associating...