Building a double hexamer of DNA helicase at eukaryotic replication origins

[摘要]：The Mcm2-7 complex, the catalytic core of the eukaryotic replicative DNA helicase, undergoes a complex series of transformations at origins of DNA replication. During G1 phase, it is loaded around double-strand DNA at origins as an inactive double hexamer, which is subsequently remodelled in situ to activate the helicase during S phase. Work in this issue of The EMBO Journal sheds light on the role of the Cdt1 protein in generating Mcm2-7 double hexamers during the loading reaction.

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